DeformableFormer: Classification of Endoscopic Ultrasound Guided Fine Needle Biopsy in Pancreatic Diseases

Endoscopic Ultrasound-Fine Needle Aspiration (EUS-FNA) is used to examine pancreatic cancer. EUS-FNA is an examination using EUS to insert a thin needle into the tumor and collect pancreatic tissue fragments. Then collected pancreatic tissue fragments are then stained to classify whether they are pancreatic cancer. However, staining and visual inspection are time consuming. In addition, if the pancreatic tissue fragment cannot be examined after staining, the collection must be done again on the other day. Therefore, our purpose is to classify from an unstained image whether it is available for examination or not, and to exceed the accuracy of visual classification by specialist physicians. Image classification before staining can reduce the time required for staining and the burden of patients. However, the images of pancreatic tissue fragments used in this study cannot be successfully classified by processing the entire image because the pancreatic tissue fragments are only a part of the image. Therefore, we propose a DeformableFormer that uses Deformable Convolution in MetaFormer framework. The architecture consists of a generalized model of the Vision Transformer, and we use Deformable Convolution in the TokenMixer part. In contrast to existing approaches, our proposed DeformableFormer is possible to perform feature extraction more locally and dynamically by Deformable Convolution. Therefore, it is possible to perform suitable feature extraction for classifying target. To evaluate our method, we classify two categories of pancreatic tissue fragments; available and unavailable for examination. We demonstrated that our method outperformed the accuracy by specialist physicians and conventional methods

Supergravity Solutions Without Tri-holomorphic U(1) Isometries

We investigate the construction of five-dimensional supergravity solutions that don't have any tri-holomorphic U(1) isometries. We construct a class of solutions that in various limits of parameters reduces to many of previously constructed five-dimensional supergravity solutions based on both hyper-Kahler base spaces that can be put into a Gibbons-Hawking form and hyper-Kahler base spaces that can't be put into a Gibbons-Hawking form. We find a new solution which is over triaxial Bianchi type IX Einstein-hyperkahler base space with no tri-holomorphic U(1) symmetry. One special case of this solution corresponds to five-dimensional solution based on Eguchi-Hanson type II geometry.Comment: 15 pages, 2 figure

Two-tone colorings and surjective dihedral representations for links

It is well-known that a knot is Fox $n$-colorable for a prime $n$ if and only if the knot group admits a surjective homomorphism to the dihedral group of degree $n$. However, this is not the case for links with two or more components. In this paper, we introduce a two-tone coloring on a link diagram, and give a condition for links so that the link groups admit surjective representations to the dihedral groups. In particular, it is shown that the link group of any link with at least 3 components admits a surjective homomorphism to the dihedral group of arbitrary degree.Comment: 10 pages, 5 figure

Leptomeningeal Metastases in a Patient with an Extragonadal Germ Cell Tumor

We present a case of leptomeningeal metastases in a 30-year-old man with an extragonadal germ cell tumor. The patient was referred to our hospital for treatment of an occipital brain metastasis. This lesion was resected, followed by whole brain radiotherapy and further chemotherapy, and a temporary complete remission was achieved. However, leptomeningeal recurrence developed, and despite salvage chemotherapy, the patient died of disease. Although multidisciplinary treatment is given to treat brain metastases of germ cell tumors, the patients’ prognosis has been unsatisfactory. The identification of a standard/effective treatment is required

Molecular architecture of inner dynein arms in situ in Chlamydomonas reinhardtii flagella

The inner dynein arm regulates axonemal bending motion in eukaryotes. We used cryo-electron tomography to reconstruct the three-dimensional structure of inner dynein arms from Chlamydomonas reinhardtii. All the eight different heavy chains were identified in one 96-nm periodic repeat, as expected from previous biochemical studies. Based on mutants, we identified the positions of the AAA rings and the N-terminal tails of all the eight heavy chains. The dynein f dimer is located close to the surface of the A-microtubule, whereas the other six heavy chain rings are roughly colinear at a larger distance to form three dyads. Each dyad consists of two heavy chains and has a corresponding radial spoke or a similar feature. In each of the six heavy chains (dynein a, b, c, d, e, and g), the N-terminal tail extends from the distal side of the ring. To interact with the B-microtubule through stalks, the inner-arm dyneins must have either different handedness or, more probably, the opposite orientation of the AAA rings compared with the outer-arm dyneins

Taurine's health influence on Japanese high school girls

<p>Abstract</p> <p>Background</p> <p>The prevalence of metabolic syndrome (MS) in children and adolescents has been increasing at an alarming rate. MS risks during childhood and adolescence adversely affect health conditions in later life. Thus, the characterization of their MS risks is a critical research field. The aims of this study are to survey the health status of Japanese adolescent females, a poorly characterized population, and to investigate the potential relationship between their MS risks and dietary factors like potassium (K) and taurine.</p> <p>Methods</p> <p>Anthropometric characteristics of 243 healthy school girls aged 13 to 18 years were measured. Serum levels of triglycerides, total cholesterol and high-density lipoprotein (HDL), and plasma levels of glucose and insulin were analyzed in fasting blood samples. We assessed overweight, disturbed lipid prolife, higher blood pressure (hBP) and higher plasma glucose (hGlc) levels as indicators of MS risks. The relationships between MS risks and urinary K or taurine excretion were investigated by dividing into higher and lower groups at medians of their urinary excretions.</p> <p>Results</p> <p>Half of junior high school (JHS) and one-quarter of senior high school (SHS) girls had at least one MS risk. The quite common risk was hGlc, the rates being 21% in JHS girls and 14% in SHS. The prevalence of being overweight and obesity were only small portions, the rate being 0% and 0% in JHS girls, and 10% and 1% in SHS, respectively. Substantial differences in the prevalence of hBP were observed between JHS (22%) and SHS (4%) girls. Furthermore, higher urinary K excretion group showed a significant decrease in triglyceride level (<it>P </it>= 0.03) and increase in HDL level (<it>P </it>= 0.003) compared with the lower. Also, the higher urinary taurine excretion group exhibited a significant reduction in triglyceride level (<it>P </it>= 0.04) compared with the lower.</p> <p>Conclusions</p> <p>These results indicate that control of plasma glucose level rather than body weight is a crucial task in Japanese pubertal girls, and that a dietary habit rich in K and taurine could improve their lipid profile. Nutritional education based on these findings would help to prevent the future development of MS in Japanese female adolescents.</p