Changing trends in otorhinolaryngology publishing

The aim of this study is to compare the changes in impact factors and citation numbers of Open Access (OA) vs subscription-based (SB) journals between 1999 and 2016 and to explore the changing trends in ORL publishing. All data extracted from SCImago Journal and Country ranking (SJR) website have been used as input for statistical analysis. The chi-square test of independency was applied in order to understand whether the ratio of number of OA journals of ORL category have dramatically changed between years 1999 and 2016. Also, the years and impact factors of journals belonging to the OA and SB journals have been graphed separately and the changes of annual SJR ranks of both journal types have been compared using one-way Z-test. There was a significant difference as the proportion of OA Journals were not equal to the proportion of SB Journals throughout the years 1999 and 2016, and it showed the tendency to increase greater compared to SB Journals (p < 0.01). Although the overall level of impact factors of SB journals was generally high, by comparing two regression models, it was obvious that the level of increase of the impact factors of OA journals were significantly higher (p < 0.01). When choosing where to publish, it is important to consider the journal's visibility, cost of publication, IF or SJR of the journal and speed of publication as well as changing trends in medical publishing nourished by the Web of Science

Ghrelin may attenuate proinflammatory cytokine-mediated neuropathic pain

Nerve damage that affects peripheral or central nerve systems leads to abnormal pain states referred to as neuropathic pain. The precise mechanisms in neuropathic pain are very complex, since they are thought to originate through multiple pathophysiological processes. There is quite evidence implicating the proinflammatory cytokines in the induction and facilitation of neuropathic pain. This pain syndrome is usually poorly controlled by available medications. Ghrelin, a peptide hormone predominantly secreted from the stomach, is an endogenous ligand to the growth hormone secretagogue receptor. Previous studies showed that ghrelin has potent anti-inflammatory effect; inhibiting proinflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha) interleukin-1 beta (IL-1 beta) and interteukin-6 (IL-6). Furthermore, there are recent studies which prove the interaction between ghrelin and the systems that play role in pain modulation. Therefore, we hypothesize that ghrelin might ameliorate neuropathic pain by diminishing the proinflammatory cytokines and also regulating pain system. (c) 2007 Published by Elsevier Ltd

Viability of crushed and diced cartilage grafts wrapped in oxidized regenerated cellulose and esterified hyaluronic acid: An experimental study

Objectives: The objective of this study was to investigate the viability of diced/crushed cartilage grafts wrapped in esterified hyaluronic acid (HYAFF) and Oxidized regenerated cellulose (Surgicel) with respect to macroscopic and microscopic parameters