IMMUNOMODULATING THERAPY BY RECOMBINANT ALPHA-2B INTERFERON AMONG CHILDREN WITH TIMOMEGALIA

The study of the enlarged thymus gland syndrome is extremely important for understanding of the immune system formation and functioning mechanisms. the purpose of this study is to conduct clinical and immunological analysis of the children, suffering from the syndrome of the enlarged thymus gland II and III degrees, who received recombinant alpha2b interferon (in suppositories). The revealed changes in the immune sys tem during timomegalia are complex and conducive to the development of the infectious and inflammatory diseases among infants, thus, determining the necessity for the adequate immune correction. The application of the recombinant alpha 2b interferon among such children allows one to uncover the immunomodulating effects, normalizing the imbalances in the immune system of children with timomegalia.Key words: timomegalia, alpha 2b interferon, immunity, immune correction, children

IMMUNOMODULATING THERAPY BY RECOMBINANT ALPHA-2B INTERFERON AMONG CHILDREN WITH TIMOMEGALIA

The study of the enlarged thymus gland syndrome is extremely important for understanding of the immune system formation and functioning mechanisms. the purpose of this study is to conduct clinical and immunological analysis of the children, suffering from the syndrome of the enlarged thymus gland II and III degrees, who received recombinant alpha2b interferon (in suppositories). The revealed changes in the immune sys tem during timomegalia are complex and conducive to the development of the infectious and inflammatory diseases among infants, thus, determining the necessity for the adequate immune correction. The application of the recombinant alpha 2b interferon among such children allows one to uncover the immunomodulating effects, normalizing the imbalances in the immune system of children with timomegalia.Key words: timomegalia, alpha 2b interferon, immunity, immune correction, children

ИММУНОМОДУЛИРУЮЩАЯ ТЕРАПИЯ РЕКОМБИНАНТНЫМ ИНТЕРФЕРОНОМ АЛЬФА-2B У ДЕТЕЙ С ТИМОМЕГАЛИЕЙ

The study of the enlarged thymus gland syndrome is extremely important for understanding of the immune system formation and functioning mechanisms. the purpose of this study is to conduct clinical and immunological analysis of the children, suffering from the syndrome of the enlarged thymus gland II and III degrees, who received recombinant alpha2b interferon (in suppositories). The revealed changes in the immune sys tem during timomegalia are complex and conducive to the development of the infectious and inflammatory diseases among infants, thus, determining the necessity for the adequate immune correction. The application of the recombinant alpha 2b interferon among such children allows one to uncover the immunomodulating effects, normalizing the imbalances in the immune system of children with timomegalia.Key words: timomegalia, alpha 2b interferon, immunity, immune correction, children.Изучение синдрома увеличенной вилочковой железы имеет большое значение для понимания механизмов становления и функционирования иммунной системы. Целью настоящего исследования было проведение клинико-иммунологического анализа у детей с синдромом увеличенной вилочковой железы II и III степеней, получавших рекомбинантный интерферон альфа-2b (в суппозиториях). Выявленные изменения в иммунной системе при тимомегалии носят комплексный характер и создают благоприятные условия для развития инфекционно-воспалительных заболеваний у детей раннего возраста и обуславливают необходимость адекватной иммунокоррекции. Применение рекомбинантного интерферона альфа-2b у таких детей позволяет выявить его отчетливо иммуномодулирующие эффекты, нормализующие дисбаланс в иммунной системе детей с тимомегалией. Ключевые слова: тимомегалия, интерферон альфа-2b, иммунитет, иммунокоррекция.(Педиатрическая фармакология. – 2007;4(4):26-29)