61 research outputs found
Association of MUTYH Gln324His and APEX1 Asp148Glu with colorectal cancer and smoking in a Japanese population
This is an Open Access article distributed under the terms of the Creative Commons Attribution Licens
Insulin resistance as early sign of hepatic dysfunction in liver cirrhosis
Glucose intolerance characterized by postprandial hyperglycemia and hyperinsulinemia
is commonly seen in patients with liver cirrhosis (LC). The aim of this study
is to clarify the relation between glucose intolerance and disorder of liver function in
patients with LC. The 75 g oral glucose tolerance test (75 g OGTT) and the hyperinsulinemic
euglycemic clamp combined with 0.2 g/kg oral glucose load (HECGL) were conducted
in 61 patients with LC. Based on the results of 75 g OGTT, the 61 patientswith LCwere divided
into groups, 21 (34.4%) patients with normal glucose tolerance (LC-NGT), 12 (19.7%)
patients with impaired glucose tolerance (LC-IGT) and 28 (45.9%) patients with diabetes
mellitus (LC-DM). Fasting plasma glucose (FPG) level was normal in 50 (82.0%) patients
with LC. All patients with LC showed insulin resistance in both peripheral (skeletal and
adipose) and hepatic tissues evaluated by HECGL, although significant correlation between
the degree of glucose intolerance and the severity of hepatic dysfunction was not observed.
Insulin resistance in both liver and peripheral tissues is the early sign in the patients with
LC. This fact indicates that nutritional care from early stages of LC would be necessary in
the patients
Usefulness of artificial endocrine pancreas during resection of insulinoma
A 71-year-old woman had an episode of syncope due to hypoglycemia of 27 mg/dl. She was diagnosed with insulinoma and scheduled for laparoscopic enucleation along with the use of an artificial endocrine pancreas (STG-22, Nikkiso Co., Ltd., Tokyo, Japan). Anesthesia was maintained with sevoflurane and remifentanil. Her blood glucose level was controlled using the artificial endocrine pancreas, which enabled continuous blood glucose monitoring and computer-operated glucose and insulin infusion to maintain the blood glucose level at a steady state. The target concentration of blood glucose was set at 80-120 mg/dl during surgery. Until removal of the tumor, the blood glucose level was kept at around 80-100 mg/dl. After removal of the tumor, the blood glucose level gradually increased, but it was kept in the normal range by the artificial endocrine pancreas. The artificial endocrine pancreas was useful to monitor and maintain blood glucose levels during and after the removal of insulinoma, without any hyper- or hypoglycemia
Relatório de estágio em farmácia comunitária
Relatório de estágio realizado no âmbito do Mestrado Integrado em Ciências Farmacêuticas, apresentado à Faculdade de Farmácia da Universidade de Coimbr
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