Acupuncture and moxibustion for stress-related disorders

Acupuncture and moxibustion, which medical doctors are licensed by the government of Japan to perform, can improve the psychological relationship between doctors and patients, especially when it is disturbed by a “game”, a dysfunctional interpersonal interaction that is repeated unintentionally. This advantage is due to the essential properties of acupuncture and moxibustion. Acupuncture and moxibustion are helpful in treating somatoform disorders, especially musculoskeletal symptoms. In Japan, a holistic acupuncture and moxibustion therapy called Sawada-style has been developed. This is based on fundamental meridian points that are considered to have effects on central, autonomic nervous, immune, metabolic, and endocrine systems to regulate the whole body balance. In addition, some of the fundamental points have effects on Qi, blood, and water patterns associated with major depression, generalized anxiety disorder, eating disorders, and somatoform disorders. The fixed protocol of Sawada-style would be suitable for large-scale, randomized, controlled studies in the future. Recent systematic reviews indicate that electroacupuncture would be a useful addition to antidepressant therapy for some symptoms accompanying fibromyalgia. Acupuncture and moxibustion are also recommended for irritable bowel syndrome, instead of Western drug therapy. Surprisingly, the dorsal prefrontal cerebral cortex, which is associated with a method of scalp acupuncture applied for gastrointestinal disorders, has been found to be activated in patients with irritable bowel syndrome. It is quite possible that regulation of this cortical area is related to the effect of scalp acupuncture. This acupuncture method can be effective not only for irritable bowel syndrome but also for other stress-related gastrointestinal disorders

Sound and Relatively Complete Belief Hoare Logic for Statistical Hypothesis Testing Programs

We propose a new approach to formally describing the requirement for statistical inference and checking whether a program uses the statistical method appropriately. Specifically, we define belief Hoare logic (BHL) for formalizing and reasoning about the statistical beliefs acquired via hypothesis testing. This program logic is sound and relatively complete with respect to a Kripke model for hypothesis tests. We demonstrate by examples that BHL is useful for reasoning about practical issues in hypothesis testing. In our framework, we clarify the importance of prior beliefs in acquiring statistical beliefs through hypothesis testing, and discuss the whole picture of the justification of statistical inference inside and outside the program logic

The autonomous inquiry-based learning and its effects among students in a secondary school in Tokyo metropolitan area : The moderation effect of self-esteem

Although previous research has shown a positive association between inquiry-based learning and student achievement, few studies have so far considered students’ characteristics. Based on the previous findings of aptitude-treatment interaction, not all students benefit equally from the same learning activities. The present study focused on the moderating role of each student’s self-esteem as an aptitude for inquiry-based learning. The purpose of this study was to investigate whether self-esteem moderates the effect of inquirybased learning in school. Participants were 627 students (305 male students, 322 female students) who entered a secondary school in Tokyo metropolitan area, Japan. The survey was conducted in March, 2016. The participants completed the questionnaire online in their school. Exploratory factor analysis on the scale of inquiry-based learning activities indicated three factors that relate to explore, experience, and discussion. After adjusting for confounding variables, multivariate logistic regression analysis showed that exploring some information in learning was positively associated with concrete image for the future occupation among students high in selfesteem. The present findings suggest the importance of self-esteem in autonomous inquiry-based learning in adolescents

Formalizing Statistical Causality via Modal Logic

We propose a formal language for describing and explaining statistical causality. Concretely, we define Statistical Causality Language (StaCL) for expressing causal effects and specifying the requirements for causal inference. StaCL incorporates modal operators for interventions to express causal properties between probability distributions in different possible worlds in a Kripke model. We formalize axioms for probability distributions, interventions, and causal predicates using StaCL formulas. These axioms are expressive enough to derive the rules of Pearl's do-calculus. Finally, we demonstrate by examples that StaCL can be used to specify and explain the correctness of statistical causal inference

Maternal supportiveness is predictive of childhood general intelligence

Data from the Early Head Start Research and Evaluation Project (N = 1075) were used to test the hypothesis that maternal supportiveness (measured at three waves from 14 to 36 months) is positively and prospectively associated with a child's general intelligence (measured at five waves from 14 months to 10 years). Bivariate correlations showed that maternal supportiveness was consistently and positively associated with a child's general intelligence. For example, maternal supportiveness as measured at 14 months was correlated with a child's general intelligence at age 10; r = 0.35. Results of autoregressive cross-lagged panel models showed maternal supportiveness directly predicted future general intelligence through age four and indirectly, via age four general intelligence, up to age 10. Additional analyses verified that the effect of maternal supportiveness was on general intelligence and not specific abilities. The results point to the importance of maternal supportiveness on general intelligence in the first decade of life.</p

ライフコースにおけるパーソナリティの変化と安定性の個人差の検討 : 被影響性の観点に着目して

学位の種別: 課程博士審査委員会委員 : （主査）東京大学教授 遠藤 利彦, 東京大学教授 岡田 猛, 東京大学教授 針生 悦子, 東京大学教授 能智 正博, 東京大学教授 佐々木 司University of Tokyo(東京大学

Molecular and virulence characteristics of an outer membrane-associated RTX exoprotein in Pasteurella pneumotropica

<p>Abstract</p> <p>Background</p> <p><it>Pasteurella pneumotropica </it>is a ubiquitous bacterium that is frequently isolated from laboratory rodents and causes various clinical symptoms in immunodeficient animals. Currently two RTX toxins, PnxIA and PnxIIA, which are similar to hemolysin-like high-molecular-weight exoproteins are known in this species. In this study, we identified and analyzed a further RTX toxin named PnxIIIA and the corresponding type I secretion system.</p> <p>Results</p> <p>The RTX exoprotein, PnxIIIA, contains only a few copies of the RTX repeat-like sequence and 3 large repeat sequences that are partially similar to the outer membrane protein found in several prokaryotes. Recombinant PnxIIIA protein (rPnxIIIA) was cytotoxic toward J774A.1 mouse macrophage cells, whereas cytotoxicity was attenuated by the addition of anti-CD11a monoclonal antibody. rPnxIIIA could bind to extracellular matrices (ECMs) and cause hemagglutination of sheep erythrocytes. Binding was dependent on the 3 large repeat sequences in PnxIIIA. Protein interaction analyses indicated that PnxIIIA is mainly localized in the outer membrane of <it>P. pneumotropica </it>ATCC 35149 in a self-assembled oligomeric form. PnxIIIA is less cytotoxic to J774A.1 cells than PnxIA and PnxIIA.</p> <p>Conclusions</p> <p>The results implicate that PnxIIIA is located on the cell surface and participates in adhesion to ECMs and enhanced hemagglutination in the rodent pathogen <it>P. pneumotropica</it>.</p

Prevalence and analysis of Pseudomonas aeruginosa in chinchillas

<p>Abstract</p> <p>Background</p> <p>Chinchillas (<it>Chinchilla laniger</it>) are popular as pets and are often used as laboratory animals for various studies. <it>Pseudomonas aeruginosa </it>is a major infectious agent that causes otitis media, pneumonia, septicaemia enteritis, and sudden death in chinchillas. This bacterium is also a leading cause of nosocomial infections in humans. To prevent propagation of <it>P. aeruginosa </it>infection among humans and animals, detailed characteristics of the isolates, including antibiotic susceptibility and genetic features, are needed. In this study, we surveyed <it>P. aeruginosa </it>distribution in chinchillas bred as pets or laboratory animals. We also characterized the isolates from these chinchillas by testing for antibiotic susceptibility and by gene analysis.</p> <p>Results</p> <p><it>P. aeruginosa </it>was isolated from 41.8% of the 67 chinchillas included in the study. Slide agglutination and pulsed-field gel electrophoresis discriminated 5 serotypes and 7 unique patterns, respectively. For the antibiotic susceptibility test, 40.9% of isolates were susceptible to gentamicin, 77.3% to ciprofloxacin, 77.3% to imipenem, and 72.7% to ceftazidime. DNA analyses confirmed that none of the isolates contained the gene encoding extended-spectrum β-lactamases; however, 2 of the total 23 isolates were found to have a gene similar to the <it>pilL </it>gene that has been identified in the pathogenicity island of a clinical isolate of <it>P. aeruginosa</it>.</p> <p>Conclusions</p> <p><it>P. aeruginosa </it>is widely spread in chinchillas, including strains with reduced susceptibility to the antibiotics and highly virulent strains. The periodic monitoring should be performed to help prevent the propagation of this pathogen and reduce the risk of infection from chinchillas to humans.</p