The Efficacy of PAF Antagonist TCV-309 in a Canine Single Lung Allotransplantation after 24 hour . Preservation

To evaluate the efficacy of TCV-309, platelet activating factor (PAF) antagonist, we investigated the use of this agent when added to the Euro-Collins solution or administered to the donor and the recipient as well as the Euro-Collins solution in the preservation of a canine lung for 24 hours. The function of the graft was assessed before harvesting and one hour after reperfusion by a unilateral pulmonary artery occlusion test. In the ECS group, donor lungs were flushed with 500 ml of the Euro-Collins solution containing 375 μg TCV-309. In the TCV group, donor and recipient dogs were pretreated with TCV-309, and donor lungs were flushed as the ECS group. Donor dogs received TCV-309 100 μg/kg bolus followed by continuous infusion of 500 μg/kg/hr for one hour. Recipient dogs received TCV-309 100 pg/kg bolus followed by continuous infusion of 500 μg/kg/hr for two hours, encompassing two hours of reperfusion. Better posttransplantation pulmonary function was obtained in the TCV group. In conclusion the PAF antagonist TCV-309 is a beneficial agent when it is administered to the donor and the recipient and added to the Euro-Collins solution in a canine model of a single lung transplantation after 24 hr preservation

Developing an SDR Test Collection from Japanese Lecture Audio Data

The lecture is one of the most valuable genres of audiovisual data. However, spoken lectures are difficult to reuse because browsing and efficient searching within spoken lectures is difficult. To promote the research activities in the spoken lecture retrieval, this paper reports a test collection for its evaluation. The test collection consists of the target spoken documents of about 2,700 lectures (604 hours) taken from the Corpus of Spontaneous Japanese (CSJ), 39 retrieval queries, the relevant passages in the target documents for each query, and the automatic transcription of the target speech data. We report the retrieval performance targeting the constructed test collection by applying a standard spoken document retrieval (SDR) method, which serves as a baseline for the forthcoming SDR studies using the test collection. We also introduce the several studies conducted by the users of the test collection.APSIPA ASC 2009: Asia-Pacific Signal and Information Processing Association, 2009 Annual Summit and Conference. 4-7 October 2009. Sapporo, Japan. Oral session: Initiatives in Spoken Document Processing (6 October 2009)