Wavelet profiles: Their application in Oryza sativa DNA sequence analysis

Here we introduce our application of the wavelet analysis method to DNA sequences. In the signal processing field, Fourier transform is popular for analyzing wave data. However, although this method can process frequency information, it fails to handle locational data. In contrast, the wavelet method accommodates both locational and frequency information for wave analysis. The wavelet method is now increasing in its importance for signal processing. Fast Fourier transform is already applied to biological sequence analysis using correlations.[1] We introduce a new method, called wavelet profile, for biological sequence analysis. Our method is based on multiresolution analysis of wavelet transform, offering data decomposition in several scaling at the same time. We applied our wavelet profile method to identifying gene loci among O. sativa genomic sequences.

Intravenous immunoglobulin therapy in proximal diabetic neuropathy

A 57-year-old man with type 2 diabetes mellitus for 10 years showed progressive loss of muscle strength in both legs, pain and muscle atrophy in the femoral region and significant weight loss. On admission, he could not stand alone and used a wheelchair. He also complained of severe pain in the lower extremities. He was diagnosed with proximal diabetic neuropathy (PDN) by characteristic clinical and electrophysiological features. Intravenous immunoglobulin therapy (IVIg 0.4 g/kg×5 days) markedly reduced the severe pain and muscle weakness in the legs. Eventually, pain assessed by the Visual Analogue Scale was relieved by 80% and muscle strength was also well recovered, thereby enabling the patient to walk with a cane. The present case suggests that IVIg therapy may be effective for the relief of pain in PDN

Intravenous immunoglobulin therapy markedly ameliorates muscle weakness and severe pain in proximal diabetic neuropathy

A 57‐year‐old man with type 2 diabetes mellitus for 10 years showed progressive loss of muscle strength in both legs, pain and muscle atrophy in the femoral region and significant weight loss. On admission, he could not stand alone and used a wheelchair. He also complained of severe pain in the lower extremities. He was diagnosed with proximal diabetic neuropathy (PDN) by characteristic clinical and electrophysiological features. Intravenous immunoglobulin therapy (IVIg 0.4 g/kg×5 days) markedly reduced the severe pain and muscle weakness in the legs. Eventually, pain assessed by the Visual Analogue Scale was relieved by 80% and muscle strength was also well recovered, thereby enabling the patient to walk with a cane. The present case suggests that IVIg therapy may be effective for the relief of pain in PDN