Chemistry and dynamics of marine stratocumulus, The

September, 1988.Bibliography: pages [82]-91

Effect of short-term school closures on the H1N1 pandemic in Japan: a comparative case study

Purpose The 2009 worldwide influenza A/H1N1 pandemic particularly affected younger people, including schoolchildren. We assessed the effects of class/school closure during the pandemic on the spread of H1N1 infection in Japan. Methods We prospectively monitored 2,141 schoolchildren in 57 classes at two elementary schools and two junior high schools in Japan, and evaluated the effects of class/school closures on the spread of H1N1 using descriptive epidemiological methods. Results The cumulative rate of H1N1 infection among these children was 40.9 % (876 children). There was a total of 53 closures of 40 classes, including school closures, during the pandemic. Time-course changes in the epidemic curve showed that school closure reduced the following epidemic peak more than class closure. A Poisson regression model showed that a longer duration of closure was significantly related to decreased H1N1 occurrence after the resumption of classes. Conclusions School closure more effectively inhibits subsequent epidemic outbreaks than class closure. Longer school closures are effective in reducing the spread of infection, and school closure should be implemented as early as possible.ArticleINFECTION. 40(5):549-556 (2012)journal articl

Fall vortex ozone as a predictor of springtime total ozone at high northern latitudes

Understanding the impact of atmospheric dynamical variability on observed changes in stratospheric O₃ is a key to understanding how O₃ will change with future climate dynamics and trace gas abundances. In this paper we examine the linkage between interannual variability in total column O₃ at northern high latitudes in March and lower-to-mid stratospheric vortex O₃ in the prior November. We find that these two quantities are significantly correlated in the years available from TOMS, SBUV, and POAM data (1978-2004). Additionally, we find that the increase in March O₃ variability from the 1980s to years post-1990 is also seen in the November vortex O₃, i.e., interannual variability in both quantities is much larger in the later years. The cause of this correlation is not clear, however. Interannual variations in March total O₃ are known to correspond closely with variations in winter stratospheric wave driving consistent with the effects of varying residual circulation, temperature, and chemical loss. Variation in November vortex O₃ may also depend on dynamical wave activity, but the dynamics in fall are less variable than in winter and spring. We do not find significant correlations of dynamic indicators for November such as temperature, heat flux, or polar average total O₃ with the November vortex O₃, nor with dynamical indicators later in winter and spring that might lead to a connection to March. We discuss several potential hypotheses for the observed correlation but do not find strong evidence for any considered mechanism. We present the observations as a phenomenon whose understanding may improve our ability to predict the dependence of O₃ on changing dynamics and chemistry

IgG4-related sclerosing cholangitis should be included as an exclusion criterion for the diagnosis of primary sclerosing cholangitis

The definitive version is available at www.blackwell-synergy.com.ArticleAMERICAN JOURNAL OF GASTROENTEROLOGY. 102(3): 691-692 (2007)journal articl

Pancreatic exocrine insufficiency: a rare cause of nonalcoholic steatohepatitis

This is an electronic version of an Article published in the American Journal of Gastroenterology 2008; 103(1): 245-246.ArticleAmerican journal of gastroenterology. 103(1): 245-246 (2008)journal articl

A Novel Heterophilic Antibody Interaction Involves IgG4

IgG4 has been implicated in a diverse set of complex pathologies - e.g. autoimmune pancreatitis (AIP), idiopathic membranous nephropathy - and carries unique features including lack of activation of the classical complement pathway and a dynamic Fab-arm exchange. We recently showed that the rheumatoid factor (RF)-like activity of IgG4 is achieved through a hitherto unknown, Fc-Fc (and not Fab-Fc as is the case in classical RF; CRF) interaction; hence the name, novel RF (NRF). Here, we further explore the resemblance/difference between CRF and NRF. As heterophilic interactions of human IgM RF (CRF) are well known, we checked whether this is the case for IgG4. Human IgG4 showed variable reactivity to animal IgGs: reacting intensely with rabbit and mouse IgGs, but weakly with others. The binding to rabbit IgG was not through the Fab (as in CRF) but via the Fc piece, as was recently shown for human IgG (NRF). This binding correlates with the IgG4 concentration per se and could therefore be of diagnostic usage and incidentally explain some observed interferences in biological assays. In conclusion, here is defined a novel heterophilic antibody interaction and is established the universality of the unique Fc-Fc binding, both involving IgG4.ArticleSCANDINAVIAN JOURNAL OF IMMUNOLOGY. 71(2):109-114 (2010)journal articl

Prevalence and distribution of extrapancreatic lesions complicating autoimmune pancreatitis

The original publication is available at www.springerlink.com.ArticleJOURNAL OF GASTROENTEROLOGY. 41(12): 1197-1205 (2006)journal articl