Efficacy of glycoprotein-based nanocurcumin/silk fibroin electrospun scaffolds: Perspective for bone apatite formation

In this research, a blend of poly (vinyl) alcohol (PVA), silk fibroin nanofibers (SF-NFs), hydroxyapatite nano pArticles (HA-NPs), and curcumin nanopArticles (Cu-NPs) were used to design a nanofibrous scaffold (NFS), by electrospun method, for their possible application in bone apatite formation. The prepared nanofibrous scaffold (NFS) was investigated using physicochemical, mechanical, cell viability, etc. The bioactivity test of NFS was evaluated after immersion in SBF (simulated body fluid). NFS from PVA, SF-NFs, HA-NPs, and Cu-NPs exhibited outstanding physicochemical, mechanical, and antibacterial properties. PVA: SF-NFs: HA-NPs: Cu-NPs scaffold excellent antimicrobial performance against E.coli (4.16 +/- 0.16 mm) and S.aureus (4.88 +/- 0.10 mm). Biocompatibility studies were assessed using human osteosarcoma MG63 cell line, which displayed 100% viable cell presence in PVA: SF-NFs: HA-NPs: Cu-NPs. Based on the characterization, results indicated that they are excellent scaffolds for bone tissue regeneration.[118C350]The award of TUBITAK 2232-International Fellowship for Outstanding Researcher (Project No: 118C350) to Dr. Rethinam Senthil is greatfully acknowledged

A New and Eco-Friendly Method for Reduction of Ketones in Water

WOS: 000477963800024This paper reports a new, practical, and environmentally friendly catalytic system for reduction of the ketones to the related alcohols with efficient reaction performance in water. Catalysts were generated in situ from rhodium, ruthenium and iridium transition metal compounds with commercially available piperidines [Piperidine (L-1), 2-hydroxymethylpiperidine (L-2), 3-hydroxymethylpiperidine (L-3), 4-hydroxymethylpiperidine (L-4), 4-hydroxypiperidine (L-5)] as bifunctional ligands. Catalyst generated from RuCl2(PPh3)(3) and 4-hydroxymethyl piperidine have shown the best activity in aqueous media which gave a 100% product yield. RuCl2(PPh3)(3), has showed a better efficiency than [RuCl2(p-cymene)](2), IrCl(PPh3)(3), or RhCl(PPh3)(3) in HCOOH-HCOONa buffer solution. This study was also investigated the relationship between the structure of hydroxymethyl piperidine ligands and the catalytic activity

Piano-stool Ru (II) arene complexes that contain ethylenediamine and application in alpha-alkylation reaction of ketones with alcohols

WOS: 000465346500010A series of piano-stool Ru (II) complexes (Ru1-7) bearing ethylenediamine with aryl and aliphatic groups were prepared and fully characterized by H-1, C-13, F-19 and P-31 NMR spectroscopy, FT-IR and elemental analysis. The crystal structures of Ru2-4 and Ru-7 were determined by X-ray crystallography. They were successfully applied to the alpha(alpha)-alkylation of aliphatic and aromatic ketones with alcohols via the borrowing hydrogen strategy in mild reaction conditions within a short time. The catalytic system has a broad substrate scope, which allows the synthesis of alpha alkylated ketones with excellent yields. The electronic and steric effects of complexes on catalytic activity were analysed. The influence of the carbon chain length of the ligand on the alpha-alkylation reaction of ketones was also investigated. The catalytic cycle was also examined by H-1-NMR spectroscopy in d(8)-toluene.Ege University and Scientific and Technological Research Council of Turkey (TUBITAK) [214Z098]The authors thank Ege University and Scientific and Technological Research Council of Turkey (TUBITAK, Project Number: 214Z098) for the financial support. The authors acknowledge Scientific and Technological Research Application and Research Center, Sinop University, Turkey, for the use of the Bruker D8 QUEST diffractometer

Synthesis and catalytic applications of Ru and Ir complexes containing N,O-chelating ligand

turkmen, hayati/0000-0001-7411-2652; Kavukcu, Serdar Batikan/0000-0002-1168-5012WOS: 000575166800007A series of monometallic complexes (Ru1-3, Ir-1(-3)) which have N,O-chelating ligand (pyrazine-2carboxylate (1), pyridine-2-carboxylate (2), quinoline carboxylate(3) and bimetallic complexes (Ru-4,Ru-5, Ir-4(,5)) bridged by pyrazine-2,3- dicarboxylate (4) and imidazole-4,5-dicarboxylate(5) were synthesized and characterized by H-1-, C-13 NMR, FT-IR, and elemental analysis. the crystal structure of Ir-2 was determined by X-ray crystallography. the complexes (Ru1-5, Ir1-5) were applied to investigate the electronic and steric effect of ligand in their catalytic activities in transfer hydrogenation and alpha(alpha)-alkylation reaction of ketones with alcohols. the activities of iridium complexes (Ir1-5) were much more efficient than ruthenium complexes (Ru1-5). the highest activity for both reactions was observed for the complex (Ir2 ) with pyridine-2-carboxylate. the Ir hydride species was monitored for both reactions. (C) 2020 Elsevier B.V. All rights reserved.Ege UniversityEge University [17-FEN-058]The authors thank to Ege University Scientific Research Fund (17-FEN-058) for the financial support. the authors acknowledge Scientific and Technological Research Application and Research Center, Sinop University, Turkey, for the use of the Bruker D8 QUEST diffractometer

Fabrication of cylindrical bone graft substitute supported by reduced graphene-oxide and nanocurcumin to promotes the bone tissue development

In this study, a prototype technique was used to develop cylindrical bone graft substitute (C-BGS) from gelatin (GEL) derived from fish skin, demineralized bone matrix (DBM) from fishbone, reduced graphene oxide (R-GO), and nanocurcumin (Nano-Cu) for their potential application in bone graft substitute. The impact of the inclusion of R-GO and Nano-Cu on the physicochemical characteristics, antibacterial, and in vitro properties of the C-BGS was assessed. The C-BGS showed compressive strength of 13.64 +/- 0.20 (MPa) and elongation at break (%) of 23.76 +/- 0.20. The antibacterial activity of C-BGS against E.coli and S.aureus was excellent. In vitro study, revealed 98% cell viability on the C-BGS. The C-BGS with physicochemical, antibacterial, and biocompatibility properties can tried as a bone graft substitute material.[118C350]Acknowledgments The award of TUBITAK 2232-International Fellowship for Outstanding Researcher (Project No: 118C350) to Dr. Rethinam Senthil is greatfully acknowledge

Curcumin nanoparticles supported gelatin-collagen scaffold: Preparation, characterization, and in vitro study

It is possible to reveal the potential of water-insoluble drugs by increasing their solubility in water with some nanotechnology techniques. Nanosuspension technology can solve this problem by increasing the water solubility and as well as bioavailability of these drugs. The present work is pointed at the evaluation of nano suspension of curcumin, a poorly water-soluble drug. The Curcumin nanoparticules (CNs) were prepared with ultrasonnication method using dichloromethane as solvent and water as antisolvent and characterized via spectroscopic methods (UV-vis and FT-IR) and Scanning Electron Microscopy (SEM). Curcumin nanoparticules Biofilms (CNs-BF) supported gelatin-collagen scaffold were prepared. Curcumin nanoparticles were obtained by nanosuspension technique. And then, to overcome the limited effects of curcumin such as solubility and bioavailability, nanoparticle films were prepared by incorporating it into the structure of biocompatible collagen gelatin scaffolds. Curcumin is limited by some factors that limit its clinical applicability, such as low oral bioavailability, poor water solubility and rapid degradation. However, they can be applied clinically when they are included in the structure of biocompatible gelatin-collagen scaffolds.2232-International Fellowship for Outstanding Researcher Program of TUBITAK [118C350]2232-International Fellowship for Outstanding Researcher Program of TUBITAK (Project No: 118C350)

C(acyl)-C(sp(2)) and C(sp(2))-C(sp(2)) Suzuki-Miyaura cross-coupling reactions using nitrile-functionalized NHC palladium complexes

Application of N-heterocyclic carbene (NHC) palladium complexes has been successful for the modulation of C-C coupling reactions. For this purpose, a series of azolium salts (1a - f) including benzothiazolium, benzimidazolium, and imidazolium, bearing a CN-substituted benzyl moiety, and their (NHC)(2)PdBr2 (2a - c) and PEPPSI-type palladium (3b-f) complexes have been systematically prepared to catalyse acylative Suzuki-Miyaura coupling reaction of acyl chlorides with arylboronic acids to form benzophenone derivatives in the presence of potassium carbonate as a base and to catalyse the traditional Suzuki-Miyaura coupling reaction of bromobenzene with arylboronic acids to form biaryls. ALL the synthesized compounds were fully characterized by Fourier Transform Infrared (FTIR), and H-1 and C-13 NMR spectroscopies. X-ray diffraction studies on single crystals of 3c, 3e and 3f prove the square planar geometry. Scanning Electron Microscopy (SEM), energy dispersive X-ray spectroscopy (EDS), metal mapping analyses and thermal gravimetric analysis (TGA) were performed to get further insights into the mechanism of the Suzuki-Miyaura cross coupling reactions. Mechanistic studies have revealed that the stability and coordination of the complexes by the CN group are achieved by the removal of pyridine from the complex in catalytic cycles. The presence of the CN group in the (NHC)Pd complexes significantly increased the catalytic activities for both reactions.Ege University [FYL-2018-20197]; Dokuz Eylul University [2010.KB.FEN.13]; 2232-International Fellowship for Outstanding Researcher Program of TUBITAK [118C350]Financial support from Ege University (Project FYL-2018-20197) is gratefully acknowledged. The authors acknowledge Dokuz Eylul University for using of the Rigaku Oxford Xcalibur Eos Diffractometer (purchased under University Research Grant No. 2010.KB.FEN.13). Dr Senthil Rethinam acknowledges the funding support granted by the 2232-International Fellowship for Outstanding Researcher Program of TUBITAK (Project No: 118C350)

Functionalized electrospun nanofibers for high efficiency removal of particulate matter

In recent years, introducing electrospun airfilters to enhance the removal of PM2.5 and PM10-2.5 has received much interest. In this study, a novel poly-(vinyl) alcohol (PVA)/carbon nanopArticle (CNP)/tea leaf extract (TLE), functionalized nanofibrous air filter (FNA) was fabricated using an electrospinning method. Novelty of the unique work in the blending of CNP and TLE, first of its kind, for the preparation of FNA. Polysaccharide crosslinked FNA has a carbon complex with two monosaccharide units to produce the intrinsic properties of the PM2.5 and PM10-2.5 removal efficiency. The FNA had promising traits of UV protection. The prepared FNA was characterized using physicochemical, mechanical, antimicrobial activity, etc., in addition to its PM2.5 and PM10-2.5 removal efficiency. Pore size and distribution study using the capillary flow porometry method has proved the structure of FNA. FNA exhibited excellent low pressure drop (110 Pa), which are promising characteristics for air purification. FNA from PVA: CNP: TLE exhibited high PM2.5 and PM10-2.5 removal efficiencies of 99.25% and 99.29%, respectively. Hence, the study proved.2232-International Fellowship for Outstanding Researcher Program of TUBITAK (Project No: 118C350).TUBITAK [118C350

Preparation of biocompatible polymeric bio-scaffold as wound healing activity: Characterization and In vivo analysis

In this study, a combination of collagen (CL), gelatin (GL) and squid ink (SI) were used to produce a biocompatible polymeric bio-scaffold (CL, CL: GL and CL: GL: SI) was examined for wound healing purposes. Biocompatible polymeric bio-scaffold (BPBS) plays an important role in wound care due to their cost-effective, good mechanical properties, bio-compatible and antimicrobial characteristics. Thermogravimetric analysis (TGA) and Fourier transform infrared spectroscopy (FTIR) of the BPBS has showed the heat stability and nature of samples, respectively, and while scanning electron microscopy (SEM) images revealed the blending of CL fiber, GL, and SI pattern interface. BPBS displayed excellent antimicrobial activity against both E.coli and S.aureus. The inhibition zone of BPBS results obtained in 4.57 +/- 0.30 mm against E.coli and 4.74 +/- 0.15 mm against S.aureus. Mechanical characteristics of BPBS shows tensile strength of 20.88 +/- 0.05 (Mpa), 17.74 +/- 0.05 (%) as Elongation at break, 26.31 +/- 0.21 (%) of flexibility and water absorption of 29.80 +/- 0.05 (%). Invitro analysis of CL: GL: SI, displayed 100% biocompatibility and cell viability was found 3rd days. In vivo study using mice by excisional animal model examined the CL: GL: SI scaffold can significantly accelerate the process of wound healing.Dr. Senthil Rethinam acknowledges the funding support granted by the 2232International Fellowship for Outstanding Researcher Program of TUBITAK, Turkey, (Project No: 118C350) .TUBITAK, Turkey [118C350