INDQ/NO, a Bioreductively Activated Nitric Oxide Prodrug

The design, synthesis, and development of INDQ/NO, a novel nitric oxide (NO) prodrug targeted by a bioreductive trigger, are described. INDQ/NO, an indolequinone-diazeniumdiolate is found to be metabolized to produce NO by DT-diaphorase, a bioreductive enzyme that is overexpressed in certain cancers and hypoxic tumors. Cell-based assays revealed that INDQ/NO induces DNA damage and is a potent inhibitor of cancer cell proliferation

Additional file 1 of Differential methylation in EGLN1 associates with blood oxygen saturation and plasma protein levels in high-altitude pulmonary edema

Additional file 1. Fig. S1 Levels of SpO2 % in HAPE-p, HAPE-f and HLs. Fig. S2 Dot plot of CpG methylation in EGLN1 in the three study groups, i.e., HAPE-p, HLs and HAPE-f. It revealed 97 CpG sites in EGLN1 CpG island 179. Fig. S3 Dot plot of CpG methylation in HIF1AN in the three study groups, i.e., HAPE-f, HAPE-p and HLs. It revealed 46 CpG sites in HIF1AN CpG island 47. Table S1 Methylation distribution of CpG sites of EGLN1 and HIF1AN in each subject of the three study groups i.e., HAPE-f, HAPE-p and HLs. Table S2 Real-time PCR conditions for EGLN1 and HIF1AN. Table S3 Sodium bisulfite-conversion-based methylation PCR Primers and conditions for EGLN1 and HIF1AN

Copper-Promoted Regioselective Intermolecular Diamination of Ynamides: Synthesis of Imidazo[1,2‑<i>a</i>]pyridines

A facile access to 3-heterosubstituted (3-oxazolidinonyl/indolyl/phenoxy) imidazo­[1,2-<i>a</i>]­pyridines from readily available 2-aminopyridines and electron-rich (internally activated) alkynes like ynamides/ynamines/ynol ethers is achieved via Cu­(OTf)₂-mediated intermolecular diamination under aerobic conditions. The reaction is highly regioselective, owing to internal electron bias, and thus led to a single regioisomer with heterosubstitution at C3

Citrus essential oils: Extraction, authentication and application in food preservation

<p>Citrus EOs is an economic, eco-friendly and natural alternatives to chemical preservatives and other synthetic antioxidants, such as sodium nitrites, nitrates or benzoates, commonly utilized in food preservation. Citrus based EOs is obtained mainly from the peels of citrus fruits which are largely discarded as wastes and cause environmental problems. The extraction of citrus oils from the waste peels not only saves environment but can be used in various applications including food preservation. The present article presents elaborated viewpoints on the nature and chemical composition of different EOs present in main citrus varieties widely grown across the globe; extraction, characterization and authentication techniques/methods of the citrus EOs; and reviews the recent advances in the application of citrus EOs for the preservation of fruits, vegetables, meat, fish and processed food stuffs. The probable reaction mechanism of the EOs based thin films formation with biodegradable polymers is presented. Other formulation, <i>viz.</i>, EOs microencapsulation incorporating biodegradable polymers, nanoemulsion coatings, spray applications and antibacterial action mechanism of the active compounds present in the EOs have been elaborated. Extensive research is required on overcoming the challenges regarding allergies and obtaining safer dosage limits. Shift towards greener technologies indicate optimistic future towards safer utilization of citrus based EOs in food preservation.</p

DABCO-catalyzed synthesis of 3-substituted-3-hydroxyindolin-2-ones in aqueous media

<p>An efficient and greener protocol for easy access to 3-susbstituted-3-hydroxy-2-oxindoles by the reaction with various substituted isatins and acetophenones is described. This protocol is widely applicable for a variety of isatins and acetophenones using water as a reaction media and 1,4-diazabicyclo[2.2.2]octane (DABCO) as catalyst with shorter reaction time and good to excellent yield of products.</p

Dunnett’s tests comparing the performance of individual half-sib families against base population and check varieties (HD2987 and HD3043).

<p>Dunnett’s tests comparing the performance of individual half-sib families against base population and check varieties (HD2987 and HD3043).</p

Scheme of recurrent selection.

<p>At the end of each cycle the progenies with higher yield and physiological attributes were selected as the base material for next cycle.</p

Correlation between different drought adaptive traits and grain yield.

<p>Traits used are biomass, Canopy Temperature (at vegetative and reproductive stages), HI,NDVI and chlorophyll content. The highlighted values indicate significant correlation at 5% level.</p

Comparison of drought tolerance of half-sib families, base population, checks (HD 2987 and HD 3043) and parents of the original cross (HI 1500 and HUW 510) on the basis of drought indices.

<p>The indices used are TOL, GMP, MPI, MRP, REI and STI. The ranks for each index are also given. Y (RF) and Y (RI) indicate yield in grams obtained per plot from rainfed and restricted irrigation conditions.</p

Mean, percentage genetic gain over mean, percentage gain over F₅ and percentage gain over check HD3043 for Canopy Temperature (CT) at vegetative stage and reproductive stage.

<p>T (p) and T(c) are the T tests conducted to check the significance of difference between half sib families with base population and check HD3043 respectively for CT.</p