Evaluation of the effectiveness of Ampicillin and Lactobacillus casei rhamnosus treatment in cases of preterm premature rupture of membranes remote from term

Objectives: Preterm premature rupture of membranes (PPROM) remote from term is an important obstetric cause of maternal and fetal adverse outcomes. The aim of our study is to examine the efficacy of ampicillin and Lactobacillus casei rhamnosus treatment in cases of PPROM remote from term. Material and methods: The study was carried out by examining the results of cases who were given Ampicillin and Lactobacillus casei rhamnosus treatment. The patients were divided into two groups. Group 1 who didn’t develop clinical chorioamnionitis and Group 2 who developed clinical chorioamnionitis. Obstetric characteristics, neonatal outcomes, adverse events were recorded. Results: A total of 46 pregnant women, 40 in Group 1 and six in Group 2, were included in the study. The frequency of clinical chorioamnionitis developing during the treatment was found to be 13.0%. Mean gestational age at diagnosis was 28.43 ± 2.38 and 28.17 ± 1.33 for Groups 1 and Group 2, respectively. Mean gestational age at the time of delivery was 32.38 ± 2.07 31.33 ± 1.63 for Group 1 and Group 2, respectively. The mean latency period for Group 1 and Group 2 was 27.45 ± 1.71 days, 23.66 ± 4.53, respectively. Sepsis developed in six newborns (15%) in Group 1, while it developed in three newborns (50%) in Group 2. While 90% of the babies in Group 1 were discharged from the hospital, this rate was 66.7% in Group 2. Conclusions: Ampicillin + Lactobacillus casei rhamnosus is an effective treatment method in PPROM cases and positively affects perinatal outcomes

Breast cancer screening: An outpatient clinic study

Introduction: Systematic screening for breast cancer is performed to reduce the current mortality rate and incidence by diagnosing the patients during the early stage and asymptomatic phase of the disease. A high quality screening program may produce a long-lasting decrease in mortality only if the treatment is of an equal standard. Patients and Method: 350 patients’ medical records, including breast physical examinations, age, gender, mammography findings, number of gravidity, parity and abortion, curettage, whether or not there is systemic and endocrinological disease present and pelvic masses were analyzed retrospectively. Result: Most of the patients (91.1%) had no breast pathological findings. 2.6% of patients had fibroadenoma and 4.6% had fibrocystic breast changes exhibited through mammography. One patient was found to have a breast mass. In that patient, tru-cut biopsy revealed infiltrating ducal carcinoma. Conclusion: A multidisciplinary cancer screening program should be maintained. With such a process, the aim is to reduce the morbidity and mortality of the disease without adversely affecting the health conditions of asymptomatic individuals based on the screening. Success is brought about by the combination of individual features. [Arch Clin Exp Surg 2017; 6(1.000): 23-27

Nitrofurantoin inhibits contractions of myometrium isolated from pregnant and nonpregnant rats

We aimed to investigate the effects of nitrofurantoin, a commonly used antibiotic for urinary tract infections, on spontaneous contractions of rat myometrium isolated from 16-day pregnant and nonpregnant rats. Myometrial strips were suspended in a standard organ bath and after the manifestation of spontaneous contractions under 1 g of resting tension, nitrofurantoin was applied to the organ bath as 50, 250 and 500 µM doses. Amplitude and frequency of contractions were recorded for 20 minutes before and after application of the drug. The bath was washed to remove the drug from the medium after recording the effect of each dose and the contractions were enrolled again to show the reversible effect of the drug. The effects of nitrofurantoin on amplitude (milligrams) and frequency of spontaneous contractions were evaluated. Data were statistically analyzed using the Students t test and p [Med-Science 2018; 7(2.000): 315-8

A Monocephalus Diprosopus Fetus: Antenatal Sonographic Findings

Monocephalus Diprosopus is the rarest form of conjoined twins. The etiology of this anomaly is stil obscure. We herein report a monocephalus diprosopus case that was diagnosed in week 19 of pregnancy was presented due to its rarity and the significance of its prenatal diagnosis. Recommended a pregnancy termination since it does not have a definitive treatment today, prenatal diagnosis made for such fetuses at an early stage bears importance in terms of lowering the severity of psychological trauma. [Med-Science 2015; 4(4.000): 2928-32

Anesthesia and Intensive Care Management in a Pregnant Woman with PRES: A Case Report

Posterior reversible encephalopathy syndrome (PRES) is a temporary condition that is diagnosed clinically, neurologically, and radiologically. Its symptoms vary, and nonspecific headaches, confusion, impairment of consciousness, nausea, vomiting, and visual impairment may occur. Acute hypertension often accompanies these symptoms. Patients can also suffer from convulsions, cortical visual impairment, and coma. Diagnosis can be difficult due to focal neurologic signs. Nevertheless, knowing the clinical risk factors can lead to the right diagnosis. It has been reported that this condition may also occur during organ transplantation, immunosuppressive treatment, and autoimmune diseases and chemotherapy, and also patients with eclampsia. In this paper, a 21-year-old, 31-week pregnant woman, who had been diagnosed with PRES and thanks to early diagnosis and treatment had fully recovered and discharged from the intensive care unit, is presented, and the relevant literature is discussed

Serum elabela levels in women with tubal ectopic pregnancy: A case-control study

Elabela, a circulating peptide hormone derived from the placenta, plays a crucial role in embryonic development and function of the human placenta during pregnancy. We aimed to investigate serum elabela levels in ectopic pregnancy. Sixty cases admitted to Emergency Department and Obstetrics and Gynecology Clinic were included in this case-control study. Thirty women with tubal ectopic pregnancy constituted Group 1 and 30 women with healthy pregnancy served as controls (Group 2). Blood samples were collected from all participants. Demographic and obstetric characteristics of the whole study cohort were also recorded. Levels of serum elabela were measured in each group by enzyme-linked immunosorbent assay . Age, gender, gestational age, obstetrics history, and body mass index of the groups were similar. Mean serum elabela levels were 7.52 ± 1.1 ng/mL and 7.05 ± 1.2 ng/mL in group 1 and group 2, respectively. There was no statistically significant difference between the two groups with respect to serum elabela levels ‎ (t=1.581, p=0.119). In the present study, serum elabela levels were not significantly different in women with ectopic pregnancies than healthy pregnancies. Since placenta is the primary source of elabela, this lack of difference might be due to the insufficient placental as well as fetal development in fallopian tubes. [Med-Science 2020; 9(2.000): 289-92