Effect of ethanolic extract of Vitex negundo leaves on experimentally induced inflammatory bowel disease in albino rats

Background: Ulcerative colitis (UC) and Crohn’s disease (CD) are collectively known as inflammatory bowel disease (IBD). Pathophysiology of IBD is not known with certainty. Immunological processes and reactive oxygen species (ROS) have been proposed to contribute considerably to development of tissue injury. Some of the intestinal and/or colonic injury and dysfunction observed in IBD is due to elaboration of these reactive species. Commonly used drugs, in particular sulfasalazine and its active moiety 5-aminosalicylic acid, are potent ROS scavengers. The present study was carried out to evaluate the effect of ethanolic extract of Vitex negundo (EEVN) leaves on experimentally induced inflammatory bowel disease in albino rats.Methods: The rats were divided into four groups of six animals each. Group A and group B received gum acacia per orally, group C received EEVN in dose of 500 mg/kg/day per orally, and group D received 5-amino salicylic acid (5-ASA) in the dose of 100 mg/kg/day per orally. All the animals were pre-treated with respective drugs (volume of drugs was kept constant at 10 ml/kg) for five days, along with the normal diet. On fifth day animals were kept fasting for 12 hours (overnight) and IBD was induced next morning in Groups B, C and D by administration of one ml of 4% acetic acid solution transrectally (TR). Group A (normal control) received 0.9% normal saline transrectally (TR) instead.Results: The results have been shown that EEVN has significant activity against experimentally induced IBD when compared to the experimental control, with near normalization of colon architecture both macroscopically as well as microscopically. Tissue oxidative stress was reduced with significant improvement in tissue levels of superoxide dismutase (SOD) and catalase (CAT). Also, significant improvement in levels of myeloperoxidase (MPO) was observed.Conclusions: It is concluded that ethanolic extract of leaves of Vitex negundo has got potent activity against experimentally induced IBD due to its anti-inflammatory and anti-oxidant properties

Performance Enhancement of DS-CDMA System using Extended BPSK Modulation Scheme

In a last few decades there has been tremendous growth and a drastic rise in wireless communication technologies. The major issue that the world is facing today with the advent of so many sophisticated wireless communication devices is efficient utilization of the spectrum. Spectrum efficiency comes together with a tradeoff factor of energy consumption. Thus, the need of the hour is an energy and bandwidth efficient technique. DS-CDMA is one of the competitive and most investigated technique in wireless communication which caters the large demand at the same time with limited bandwidth. Existing modulation techniques does not promise to provide better performance in case of higher noise. Therefore, one looks for a better BER stipulated modulation format to improve and enhance the performance of the system. This article revisits conventional Binary phase shift keying method and compares its performance in terms of BER with a special Extended Binary Phase Shift Keying (EBPSK) modulation format for a DS- CDMA system. EBPSK scheme is flexible and simple which is easily integrated in a network and assures improved and enhanced performance

Leveraging Multiscale Adaptive Object Detection and Contrastive Feature Learning for Customer Behavior Analysis in Retail Settings

Multiscale adaptive object detection is a powerful computer vision technique that holds great potential for customer behavior analysis in various domains. By accurately detecting and tracking objects of interest, such as customers or products, at different scales, this approach enables detailed analysis of customer behavior. It allows businesses to track customer movements, interactions with products, and dwell times, providing valuable insights into shopping patterns and preferences. The application of multiscale adaptive object detection in customer behavior analysis offers businesses the opportunity to optimize store layouts, product placements, and marketing strategies, leading to enhanced customer experiences and improved business performance. In this paper, we introduce an innovative technique for object detection that leverages contrastive feature learning to augment the efficacy of multiscale object detection. Our methodology incorporates a contrastive loss function to extract discriminative features that exhibit resilience to scale and perspective disparities. This empowers our model to precisely detect objects across a broad range of sizes and viewpoints, even in arduous scenarios encompassing partial occlusion or low contrast against the background. Through comprehensive experiments conducted on benchmark datasets, we demonstrate that our approach surpasses state-of-the-art methodologies in terms of both accuracy and efficiency

Tuberculous abdominal cocoon – a report of 6 cases and review of the Literature

<p>Abstract</p> <p>The abdominal cocoon is a rare cause of intestinal obstruction that is usually diagnosed at the time of laparotomy. It is usually of unknown origin, although at times, it may be seen secondary to a variety of conditions. Tuberculosis is an infrequently implicated cause of abdominal cocoon, and has only occasionally been reported previously in the Literature. This paper presents our experience with tubercular cocoon as a cause of intestinal obstruction, and discusses the surgical implications of the same.</p

Histopathological study of Tumor and tumor like lesions of Oral cavity and Oropharynx: Tumor and tumor like lesions of Oral cavity and Oropharynx

Objective: The Objective is Histopathological study of Tumor and tumor like lesions of Oral cavity and oropharynx. Methodology: This study was conducted in the Department of Pathology, SBKS Medical Institute and Research Centre, Piparia for a period of 1 year. 100 oral biopsies received from the ENT department were studied. Clinical details were obtained from the requisition form. Biopsies received were processed and stained with Hematoxyllin and Eosin ( H &amp; E ) . Histopathological diagnosis regarding type and differentiation was made. Results: Amongst 100 cases of oral cavity and oropharynx biopsies analysed&nbsp; in present study, malignant lesions were 90 (90%), premalignant lesions were 4 (4%) and benign lesions were 6 (6%).The study included 86 cases (86%) of squamous cell carcinoma, 2 cases (2%) of verrucous carcinoma, 1 case (1%) of adenosquamous carcinoma, 1 case (1%) of adenocarcinoma, 3 cases (3%) of leukoplakia, 1 case (1%) of severe dysplasia, 3 cases (3%) of pleomorphic adenoma and 1 case (1%)&nbsp; each of pyogenic granuloma, squamous papilloma, ossifying fibroma.Maximum number of cases were of squamous cell carcinoma (86%).Maximum number of cases were seen in&nbsp; age group of 36-45 years, the youngest patient was 25 years old. There was male preponderance for oral and oropharyngeal lesions (73%) as compared to females (27%). Male : Female ratio was 1:0.37.Most common site of the lesion was tongue (41%) followed by buccal mucosa (30%).Majority of the tumors were well differentiated.. Conclusion: Males are more likely to develop lesions of the oral cavity and oropharynx than females. Typically, older age groups are affected. Drinking alcohol, smoking, and chewing tobacco can contribute to oral and oropharyngeal lesions. The most frequent place implicated is the tongue. The most prevalent histological variation is squamous cell carcinoma, and the majority of these tumors are well differentiated

A retrospective comparative study in patients with SUNA and SUNCT

Introduction: Short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) and short-lasting unilateral neuralgiform headache attacks with cranial autonomic symptoms (SUNA) are rare primary headache disorders. Aim: The aim of the study is to describe and compare the clinical characteristics of patients with SUNA and SUNCT. Methods: Patients with SUNCT or SUNA observed in a neurology clinic of a tertiary hospital in India between January 2017 and December 2022 were evaluated. Results: Thirteen patients with SUNA (seven female, 54%) and 16 patients with SUNCT (nine female, 56%) were identified for the evaluation. The mean ages at the onset of SUNA and SUNCT were 36.8.5 ± 8.1 years and 37.2 ± 8.4 years, respectively. The age of onset in our patients was somewhat younger than that of other large series. The demographic and clinical features of SUNA patients were comparable to those of SUNCT patients. Orbital/retro-orbital area was the most common site of pain in both types of headaches. The pattern of pain was noted as single stab (in all patients), repetitive stabs (SUNA vs. SUNCT: 77% vs. 75%), and sawtooth patterns (SUNA vs. SUNCT: 23% vs. 25%). The majority of attacks in both groups lasted less than two minutes. Conjunctival injection and tearing were present in all SUNCT patients (as a part of the diagnostic criteria). The prevalence of conjunctival injection and tearing in SUNA was 46% and 31%, respectively. All patients reported spontaneous attacks. Triggers were reported in seven (54%) patients with SUNA and nine (56%) with SUNCT. Only one patient in each group had a refractory period following a trigger-induced episode. Two patients in the SUNCT group had compression of the trigeminal nerve by a vascular loop. Conclusion: This is the largest case series from India. There were no significant differences between patients with SUNA and SUNCT