Association results in Japanese woman of previously identified SNPs with age at menarche in Caucasian woman.

<p>Genotyping result of 15,495 Japanese subjects were anlayzed in this study. Imputed SNPs with R2 of less than 0.7 were excluded from this analysis. A1 frequency of JPT were those from release 24 Hapmap JPT. N.D.; no data. References: 1 Elks et al Nat Genet 2010, 2 He et al Nature Genet 2009, 3 Liu et al Plos Genet 2009. P-value of 0.0015 (0.05/33) was set at the significant threshold for this candidate analysis.</p>*<p>:Effect size and S.E. of allele1 on age at menarche (year per allele) and P-values were obtained by inverse-variance method.</p>**<p>Concordance of association direction between this study and the previous report.</p

Regional association plot at rs364663.

<p>Upper panel; <i>P</i> values of genotyped SNPs are plotted (as −log₁₀ values) against their physical location on chromosome 6 (NCBI Build 36). Estimated recombination rates from HapMap JPT shows the local LD structure. Inset; Colors of other SNPs indicate LD with rs2596542 according to a scale from <i>r</i>² = 0 to <i>r</i>² = 1 based on pair-wise <i>r</i>² values from HapMap JPT. Lower panel; Gene annotations from the University of California Santa Cruz genome browser.</p

Association of rs364663 with age at menarche.

*<p>Effect size and S.E. of allele1 on age at menarche (year per allele) and P-values were obtained by inverse-variance method.</p

The result of genome wide association analysis of age at menarche.

<p>Genotyping result of 15,495 Japanese subjects were anlayzed in this study. Imputed SNPs with R2 of less than 0.7 were excluded from this analysis. A1 frequency of JPT was those from release 24 Hapmap JPT.</p>*<p>Effect size and SE of allele1 on age at menarche (year per allele) and P-values were obtained by inverse-variance method.</p

Results from meta-analysis of four genome-wide association studies.

<p>A total of 15,495 female samples were analyzed in this study.</p

Characteristics of study population.

<p>Characteristics of study population.</p

Additional file 1: Figure S1. of Expression of Par3 polarity protein correlates with poor prognosis in ovarian cancer

Par3 is sufficiently knocked down at 24, 48, and 72 h. JHOC cells were transfected with siPar3 or control siRNA (siControl). Total cell extracts were then taken after 24, 48, and 72 h. Par3 and ι-Tubulin protein were detected by western blotting. (PPTX 139 kb

Measurement of the signaling entropy in GSE63514.

<p>The entropy rate was significantly higher according to the disease progression (Kruskal-Wallis test, <i>p</i> < 0.0001). Cancer; invasive cancer.</p

Measurement of the signaling entropy in GSE27678.

<p>(A) Boxplot of the entropy rate from whole samples. The entropy rate increased according to the disease progression (Kruskal-Wallis test, <i>p</i> < 0. 001). Among them, the entropy rate from the cell line was highest, as described in the literature [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0176353#pone.0176353.ref009" target="_blank">9</a>]. (B) Entropy rate from each platform. ○ represents the data obtained from the Affymetrix Human Genome U133A 2.0 Array, and * represents the data obtained from the Affymetrix Human Genome U133 Plus 2.0 Array. The distribution patterns of the entropy rate seemed slightly different among the platforms.</p

Comparison of the number of endometriotic lesions between wild type and 12/15-LOX-KO mice with or without EPA administration.

<p>Endometriotic lesions were generated in wild type (WT: black) and 12/15-LOX-KO (stripe) mice with or without oral administration of 5% EPA ethyl ester. The number of endometriotic lesions was compared between the wild type and 12/15-LOX-KO mice with or without EPA oral administration (n = 4 in each group). Mean values with standard deviations are presented. Asterisks indicate those comparisons with statistical significance (p<0.05).</p