Peripheral giant cell granuloma. Clinicopathologic study of 224 new cases and review of 956 reported cases

The clinical and histopathological features of 224 new cases of peripheral giant cell granuloma were studied. In addition, the data from 956 previously reported cases in the literature were evaluated and compared with the present series. Females were found to be more commonly affected than males. All age groups were found to be affected with a relative predilection from 40 to 60 years of age. The mandible was more often affected than the maxilla. Clinically, the lesions were red in color, had a smooth surface and were rubbery or with a soft consistency. The most characteristic histologic features included a non-encapsulated highly cellular mass with abundant giant cells, inflammation, interstitial hemorrhage, hemosiderin deposits, mature bone or osteoid. © 1988 Munksgaard International Publishers Ltd

Tooth- and tissue-supported provisional restorations for the treatment of patients with extended edentulous spans

Dental implants have been used successfully for decades in the treatment of edentulous patients and offer great comfort compared with complete dentures. However, completely edentulous patients or patients with several teeth with poor prognosis that will be all extracted have to be provided with an interim complete denture until the implants have been uncovered. Complete dentures are a less attractive option for the patients because of functional, esthetic, and psychological reasons. The use of complete dentures over implants during the patients' healing period has been associated with numerous complications. The aim of this paper was to present a new type of provisional restoration supported by hopeless teeth and soft tissues. CLINICAL SIGNIFICANCE These provisional restorations can be used during the osseointegration period to avoid the use of a complete denture. The teeth can thus be restored with fixed restorations during the whole osseointegration period to provide better comfort and avoid the psychological stress of using a removable prosthesis. Additionally, the problems associated with dentures over implants or grafts (pressure, implant exposure, etc.) can be eliminated. © 2009 Wiley Periodicals, Inc

Perioperative Thyroid Hormone Kinetics in Patients Undergoing Major Oral and Maxillofacial Operations

Purpose: The aim of this study was to investigate the perioperative response of serum thyroid hormones in patients who underwent extensive maxillofacial operations with desflurane (0.2 to 1.5 MAC) and remifentanil (0.05 to 0.3 μg/kg/min) anesthesia. Materials and Methods: Serum thyroxine, total and free triiodothyronine, thyroid-stimulating hormone, interleukin-1β and 6, TNF-α, free fatty acids, S100B protein, CRP, as well as amyloid A protein were measured in 13 patients subjected to extensive oral and maxillofacial operations. Samples were collected before anesthesia induction, at the end, and 6, 12, 24, and 72 hours after the end of surgery. Patients during the study fasted, and at the postoperative period received Ringer's saline or with 5% dextrose alternatively, at the rate of 0.5 to 1.5 mL/kg/hr. Results: Thyroid hormones concentrations showed a significant decrease over time whereas their values recovered to the baseline 72 hours after surgery. Interleukin 1β, 6, S100B protein, CRP, serum amyloid A protein, and free fatty acids showed a significant increase 6, 12, and 24 hours after the end of the operation as related to the basal value. No significant clinical complications were recorded over the study. Conclusion: Patients undergoing extensive oral and maxillofacial surgery exhibit marked decrease in serum thyroid hormones. Stress response, anesthesia, and perioperative fasting may be decisive factors eliciting this response. These metabolic derangements do not deteriorate the clinical outcome and subsequently may be an adaptive response for energy preservation in various organs. © 2007 American Association of Oral and Maxillofacial Surgeons