2 research outputs found
Serum folate and B12 levels in association with cognitive impairment among seniors: results from the VELESTINO study in Greece and meta-analysis.
OBJECTIVE: To summarize existing evidence on the effect of serum folate and vitamin B12 levels on cognitive impairment among elders via a meta-analysis, also including unpublished data from a cross-sectional study of seniors ( > 65 years) residing in Velestino, Greece. METHOD: Serum measurements and Mini-Mental State Examination (MMSE) assessments were available for 593 Velestinians. In addition, 12 studies availing data on folate blood levels (N = 9,747) and 9 on B12 (N = 8,122) were identified following a search algorithm; pooled effect estimates were derived. RESULTS: Cognitive impairment (MMSE < 24) among Velestenians was associated with lower education level in both genders; decreased social activity, depressive symptoms and low folate levels in males; older age in females. Meta-analyses showed an adverse effect of low-folate levels on cognition (OR: 1.66, 95% CI: 1.40-1.96); B12 was nonsignificantly associated (OR: 1.11, 95% CI: 0.88-1.40). DISCUSSION: Low folate levels are associated with cognitive impairment of seniors; underlying pathophysiological mechanisms should be further explored
Serum Folate and B12 Levels in Association With Cognitive Impairment Among Seniors: Results From the VELESTINO Study in Greece and Meta-Analysis
Objective: To summarize existing evidence on the effect of serum folate
and vitamin B12 levels on cognitive impairment among elders via a
meta-analysis, also including unpublished data from a cross-sectional
study of seniors ( > 65 years) residing in Velestino, Greece. Method:
Serum measurements and Mini-Mental State Examination (MMSE) assessments
were available for 593 Velestinians. In addition, 12 studies availing
data on folate blood levels (N = 9,747) and 9 on B12 (N = 8,122) were
identified following a search algorithm; pooled effect estimates were
derived. Results: Cognitive impairment (MMSE < 24) among Velestenians
was associated with lower education level in both genders; decreased
social activity, depressive symptoms and low folate levels in males;
older age in females. Meta-analyses showed an adverse effect of
low-folate levels on cognition (OR: 1.66, 95% CI: 1.40-1.96); B12 was
nonsignificantly associated (OR: 1.11, 95% CI: 0.88-1.40). Discussion:
Low folate levels are associated with cognitive impairment of seniors;
underlying pathophysiological mechanisms should be further explored