Study on the Effect of Atomic Bomb Radiation on Thyroid Function

The thyroid function of 6112 cases directly exposed to the atomic bomb within 1.5 km (exposed group) and of 3047 cases directly exposed beyond 3.0 km from the hypocenter (control group) was analyzed and the following results were obtained. 1) The frequency distribution curves of TSH values of both groups closely resembled each other in males, but the curve of the exposed group deviated to the right due to high TSH values. In females, the distribution width of TSH values of the exposed group was wide with a low peak and when compared to the control group, the curve was remarkably deviated to the right due to TSH values. 2) The frequency of hypothyroidism was 1.22% in males of the exposed group and 0.35% in males of the control group, while in females it was 7.08% and 1.18%, respectively, showing a significantly higher rate in the exposed group in both sexes. By exposure dose, the frequency was 1.03% in males of the 1-99 rad group and with increase of exposure dose the frequency elevated, being 3.67% at exposure dose of 200 rad or more. In females, the frequency was 6.23% and 7.76%, respectively, showing a significantly higher frequency when compared to the control group. 3) The prevalence rate of positive MCHA among the cases of hypothyroidism was 16.4% in males of the exposed group and 88.9% in males of the control group, while in females the prevalence was 25.3% and 63.3%, respectively, showing a remarkably low rate in the exposed group

PAR-1受容体拮抗薬の薬理学的研究

取得学位：博士(薬学)，学位授与番号：博甲第598号，学位授与年月日：平成15年9月30日,学位授与年：200

Pilot Analysis of Asbestos-induced Diffuse Pleural Thickening with Respiratory Compromise

We investigated the clinical features of asbestos-induced diffuse pleural thickening (DPT) with severe respiratory compromise. We conducted a retrospective study of consecutive subjects with asbestos-induced DPT. Medical data such as initial symptoms, radiological findings, respiratory function test results, and clinical course were collected and analyzed. There were 24 patients between 2003 and 2012. All were men, and the median age at the development of DPT was 74 years. The top occupational category associated with asbestos exposure was dockyard workers. The median duration of asbestos exposure was 35.0 years, and the median latency from first exposure to the onset of DPT was 49.0 years. There were no significant differences in respiratory function test results between the higher and lower Brinkman index groups or between unilateral and bilateral DPT. Thirteen patients had a history of benign asbestos pleural effusion (BAPE), and the median duration from pleural fluid accumulation to DPT with severe respiratory compromise was 28.4 months. DPT with severe respiratory compromise can develop after a long latency following occupational asbestos exposure and a history of BAPE

Observation of line emissions from Ni-like W46 + ions in wavelength range of 7–8 Å in the Large Helical Device

Tungsten W46+ lines were successfully observed in the extreme ultraviolet (EUV) wavelength range of 7 ∼ 8 Å in the Large Helical Device (LHD). Tungsten ions are distributed in the neutral beam injection (NBI) heated LHD plasma by injecting a pellet consisting of a small piece of tungsten metal wire enclosed by a carbon tube. While the electron temperature has a sudden drop due to the pellet injection, it can be recovered by applying electron cyclotron heating (ECH) together with continuous NBI heating. It is found that a W46+ line at 7.93 Å is emitted when the central electron temperature ranges around 3.4 keV with relatively high intensity and is isolated from other intrinsic impurity lines. The 7.93 Å line consists of two lines of forbidden transitions which are blended with each other; an electric quadrupole (E2) transition at 7.928 Å and a magnetic octupole (M3) transition at 7.938 Å. Observation of W46+ lines in the stellarator experiments is reported for the first time in the present study while the lines have been already observed in several tokamak experiments. The electron temperature dependence of the emission intensity of the 7.93 Å line agreed well with that of the fractional abundance of W46+ ions calculated using the ionization and recombination rate coefficients available in the ADAS database under the assumption of the collisional ionization equilibrium. The 7.93 Å line observed in this study will be used as tools for further spectroscopic researches, such as the measurements of spatial profile of W46+ ions using a space-resolved EUV spectrometer developed in LHD

EUV spectral shape variation of tungsten unresolved transition arrays in electron temperature range of 2–4 keV observed in the Large Helical Device

Spectroscopic studies of emissions released from tungsten ions combined with a pellet injection technique have been conducted in the Large Helical Device. The tungsten Unresolved Transition Array (UTA) spectrum was observed in the wavelength ranges of extreme ultraviolet (EUV) 6–60 Å and 130–340 Å, and the electron temperature dependence of the UTA spectral shape was investigated in the electron temperature region < 4.3 keV. The UTAs of W24+–W33+ at 20–33 Å, W37+–W42+ at 45–47 Å, W27+–W29+ at 48–55 Å, and W7+– W27+ at 170–210 Å were observed. Unidentified UTAs were also found at 230–270 Å and 280–320 Å. As the electron temperature increased further above 4 keV, the W37+–W42+ UTA at 45–47 Å was maintained, while the other UTAs became less intense