Electrospun poly(d/l-lactide-co-l-lactide) hybrid matrix: a novel scaffold material for soft tissue engineering

Electrospinning is a long-known polymer processing technique that has received more interest and attention in recent years due to its versatility and potential use in the field of biomedical research. The fabrication of three-dimensional (3D) electrospun matrices for drug delivery and tissue engineering is of particular interest. In the present study, we identified optimal conditions to generate novel electrospun polymeric scaffolds composed of poly-d/l-lactide and poly-l-lactide in the ratio 50:50. Scanning electron microscopic analyses revealed that the generated poly(d/l-lactide-co-l-lactide) electrospun hybrid microfibers possessed a unique porous high surface area mimicking native extracellular matrix (ECM). To assess cytocompatibility, we isolated dermal fibroblasts from human skin biopsies. After 5 days of in vitro culture, the fibroblasts adhered, migrated and proliferated on the newly created 3D scaffolds. Our data demonstrate the applicability of electrospun poly(d/l-lactide-co-l-lactide) scaffolds to serve as substrates for regenerative medicine applications with special focus on skin tissue engineering

Metadata describing the Kharaa Yeröö River Basin Water Quality Database

n the framework of the BMBF funded project on Integrated Water Resources Management in Central Asia (Model region Mongolia, MOMO project, www.iwrm-momo.de) the objectives focused on supplementing, validating and extending the existing surveillance monitoring to the entire river basin for the time series 2006-2017. The MOMO monitoring programme was set up in order to observe seasonal variation in various water quality parameters along the main river course and its tributaries. A detailed sampling survey was carried out along the Kharaa River in the spring, summer and autumn of 2006 to 2017, extending from the headwaters in the Khentii Mountains to the outlet of the river basin. An additional continuous monthly monitoring programme for surface water quality was carried out upstream (Deed Guur) and downstream of Darkhan city (Buren Tolgoi) including the outlet of WWTP Darkhan in the time between 2007 and 2017. This strategy provides information for the efficient and effective design of future monitoring programmes with a focus on operational or investigative issues. The types of water sampling programmes included initial surveys as well as investigative and operational monitoring, point-source characterization, intensive surveys, fixed-station-network monitoring, groundwater monitoring, and special surveys involving chemical and biological monitoring. The water analyses have a focus on nutrients, heavy metals and metalloids, chloride, boron and the main physical water parameters. The dataset comprises also fluvial sediment analyses on heavy metals. In addition in 2017 a special hygienic monitoring (total coliforms, E. coli and fecal coliforms) has been carried out and was included in this database