Sociodemographic Characteristics of Children and Households, total children participants N = 483.

Sociodemographic Characteristics of Children and Households, total children participants N = 483.</p

Crude Seroprevalence and Seroprevalence Differences and Ratios for Children by Individual Characteristics.

Crude Seroprevalence and Seroprevalence Differences and Ratios for Children by Individual Characteristics.</p

KAP Survey Questionnaire and Scoring.

BackgroundDengue fever is a mosquito-borne viral disease that is associated with four serotypes of the dengue virus. Children are vulnerable to infection with the dengue virus, particularly those who have been previously infected with a different dengue serotype. Sufficient knowledge, positive attitudes, and proper practices (KAP) are essential for dengue prevention and control. This study aims to estimate the dengue seropositivity for study participants and to examine the association between households’ dengue-related knowledge, attitudes, and practices (KAP), and children’s risk of dengue seropositivity, while accounting for socioeconomic and demographic differences in Brazil.Methodology/Principal findingsThis analysis was based on a cross-sectional study from Fortaleza, Brazil between November 2019, and February 2020. There were 392 households and 483 participant children who provided a sample of sufficient quality for serological analysis. The main exposure was a household’s dengue-related knowledge, attitudes, and practices, assessed through a questionnaire to construct a composite KAP score categorized into three levels: low, moderate, and high. The main outcome is dengue immunoglobulin G(IgG) antibodies, collected using dried blood spots and assessed with Panbio Dengue IgG indirect ELISA (enzyme-linked immunosorbent assays) test commercial kits.The estimated crude dengue seroprevalence among participating children (n = 483) was 25%. Five percent of households (n = 20) achieved a score over 75% for KAP, sixty-nine percent of households (n = 271) scored between 50% and 75%, and twenty-six percent of households (n = 101) scored lower than 50%. Each KAP domain was significantly and positively associated with the others. The mean percentage scores for the three domains are 74%, 63%, and 39% respectively. We found high household KAP scores were associated with an increased adjusted relative risk (aRR) of seropositivity (aRR: 2.11, 95% CI: 1.11–4.01, p = 0.023). Household adult respondents’ education level of elementary school or higher was negatively associated with children’s risk of being seropositive (aRR: 0.65, 95% CI: 0.48–0.87, p = 0.005). The risk of seropositivity in older children (6–12 years old) was over 6 times that of younger children (2–5 years old) (aRR: 6.08, 95% CI: 3.47–10.64, pConclusions/SignificanceOur results provide insight into the prevalence of dengue seropositivity in Fortaleza, Brazil in children, and certain demographic and socioeconomic characteristics associated with children’s risk of being seropositive. They also suggest that KAP may not identify those more at-risk for dengue, although understanding and enhancing households’ KAP is crucial for effective community dengue control and prevention initiatives.</div

Sociodemographic Characteristics of Children and Households After Imputation.

Sociodemographic Characteristics of Children and Households After Imputation.</p

Kendall Rank Correlation and Chi-Square Test Summary.

Kendall Rank Correlation and Chi-Square Test Summary.</p

Mean Percentage Score of KAP Questions with 95% Confidence Interval.

Mean Percentage Score of KAP Questions with 95% Confidence Interval.</p

Household and Children’s Sample Size per Borough.

BackgroundDengue fever is a mosquito-borne viral disease that is associated with four serotypes of the dengue virus. Children are vulnerable to infection with the dengue virus, particularly those who have been previously infected with a different dengue serotype. Sufficient knowledge, positive attitudes, and proper practices (KAP) are essential for dengue prevention and control. This study aims to estimate the dengue seropositivity for study participants and to examine the association between households’ dengue-related knowledge, attitudes, and practices (KAP), and children’s risk of dengue seropositivity, while accounting for socioeconomic and demographic differences in Brazil.Methodology/Principal findingsThis analysis was based on a cross-sectional study from Fortaleza, Brazil between November 2019, and February 2020. There were 392 households and 483 participant children who provided a sample of sufficient quality for serological analysis. The main exposure was a household’s dengue-related knowledge, attitudes, and practices, assessed through a questionnaire to construct a composite KAP score categorized into three levels: low, moderate, and high. The main outcome is dengue immunoglobulin G(IgG) antibodies, collected using dried blood spots and assessed with Panbio Dengue IgG indirect ELISA (enzyme-linked immunosorbent assays) test commercial kits.The estimated crude dengue seroprevalence among participating children (n = 483) was 25%. Five percent of households (n = 20) achieved a score over 75% for KAP, sixty-nine percent of households (n = 271) scored between 50% and 75%, and twenty-six percent of households (n = 101) scored lower than 50%. Each KAP domain was significantly and positively associated with the others. The mean percentage scores for the three domains are 74%, 63%, and 39% respectively. We found high household KAP scores were associated with an increased adjusted relative risk (aRR) of seropositivity (aRR: 2.11, 95% CI: 1.11–4.01, p = 0.023). Household adult respondents’ education level of elementary school or higher was negatively associated with children’s risk of being seropositive (aRR: 0.65, 95% CI: 0.48–0.87, p = 0.005). The risk of seropositivity in older children (6–12 years old) was over 6 times that of younger children (2–5 years old) (aRR: 6.08, 95% CI: 3.47–10.64, pConclusions/SignificanceOur results provide insight into the prevalence of dengue seropositivity in Fortaleza, Brazil in children, and certain demographic and socioeconomic characteristics associated with children’s risk of being seropositive. They also suggest that KAP may not identify those more at-risk for dengue, although understanding and enhancing households’ KAP is crucial for effective community dengue control and prevention initiatives.</div

Multivariable Regression Model of Sociodemographic Predictors of Children’s Serology Results.

Multivariable Regression Model of Sociodemographic Predictors of Children’s Serology Results.</p

Impact of the Adalimumab Patient Support Program on Clinical Outcomes in Ankylosing Spondylitis: Results from the COMPANION Study

<p></p><p><b>Article full text</b></p> <p><br></p> <p>The full text of this article can be found here<b>.</b> <a href="https://link.springer.com/article/10.1007/s40744-018-0109-3">https://link.springer.com/article/10.1007/s40744-018-0109-3</a></p><p></p><p></p><p> </p><p><br></p> <p><b>Provide enhanced content for this article</b></p> <p><br></p> <p>If you are an author of this publication and would like to provide additional enhanced content for your article then please contact <a href="http://www.medengine.com/Redeem/”mailto:[email protected]”"><b>[email protected]</b></a>.</p> <p><br></p> <p>The journal offers a range of additional features designed to increase visibility and readership. All features will be thoroughly peer reviewed to ensure the content is of the highest scientific standard and all features are marked as ‘peer reviewed’ to ensure readers are aware that the content has been reviewed to the same level as the articles they are being presented alongside. Moreover, all sponsorship and disclosure information is included to provide complete transparency and adherence to good publication practices. This ensures that however the content is reached the reader has a full understanding of its origin. No fees are charged for hosting additional open access content.</p> <p><br></p> <p>Other enhanced features include, but are not limited to:</p> <p><br></p> <p>• Slide decks</p> <p>• Videos and animations</p> <p>• Audio abstracts</p> <p>• Audio slides</p><br><p></p

Temporal trends in monthly estimates of malaria test positivity rate from health-facility-based surveillance, incidence of malaria from cohort studies, and daily human biting rate from entomology surveys.

<p>Yellow vertical bars indicate when universal distribution of long-lasting insecticidal nets occurred. Pink vertical bars indicate when each round of indoor residual spraying with bendiocarb was implemented. Daily human biting rate is the number of female <i>Anopheles</i> mosquitoes captured per house-night of collection. PPY, per person-year.</p