A Diversity Doctor's Best Lessons from the Campus

Review of the book: "Taking on Diversity: How We Can Move from Anxiety to Respect: A Diversity Doctor's Best Lessons from the Campus." By Rupert W. Nacoste. Amherst, NY: Prometheus Books, 2015. ISBN: 978-1-63388026-9

The Implementation of the Coaching Approach to Professional Experience (CAPE) Model in Indonesian initial Teacher education: The Participants’ Perspectives

Professional experience is considered essential to enable pre-service teachers (PSTs) to implement what they have learned during their initial teacher education (ITE) program to school environments. There are multiple models of professional experience that address the issue of integrating theory and practice. This article reports on findings of the implementation of the Coaching Approach to Professional Experience (CAPE) model in an ITE program in Jambi University, Indonesia. Using qualitative focus groups, this research focuses on the perceptions of PSTs, a school principal, mentor teachers, teacher educators (lecturer) and a coach regarding the implementation of the CAPE model. The research findings indicate that the role of the coach helped PSTs as they were able to individualise and focus on developing teaching skills. However, several weaknesses were also identified. In adapting the model to Jambi University’s context, the structure of the CAPE model was too general. The coach working with PSTs was not entirely free from her/his teaching duties, thus limiting the PST-coach interactions. This article discusses these findings and concludes by offering recommendations for future adaptions of the CAPE model in Indonesia and beyond

Test–Retest Reproducibility of In Vivo Magnetization Transfer Ratio and Saturation Index in Mice at 9.4 Tesla

Background: Magnetization transfer saturation (MTsat) imaging was developed to reduce T1 dependence and improve specificity to myelin, compared to the widely used MT ratio (MTR) approach, while maintaining a feasible scan time. As MTsat imaging is an emerging technique, the reproducibility of MTsat compared to MTR must be evaluated. Purpose: To assess the test–retest reproducibility of MTR and MTsat in the mouse brain at 9.4 T and calculate sample sizes potentially required to detect effect sizes ranging from 6% to 14%. Study Type: Prospective. Subjects: Twelve healthy C57Bl/6 mice. Field Strength/Sequence: 9.4 T; magnetization transfer imaging using FLASH-3D Gradient Echo; T2-weighted TurboRARE spin echo. Assessment: All mice were scanned at two timepoints (5 days apart). MTR and MTsat maps were analyzed using mean region-of-interest (ROIs: corpus callosum [CC], internal capsule [IC], hippocampus [HC], cortex [CX], and thalamus [TH]), and whole brain voxel-wise analysis. Statistical Tests: Bland–Altman plots were used to assess biases between test–retest measurements. Test–retest reproducibility was evaluated via between and within-subject coefficients of variation (bsCV and wsCV, respectively). Sample sizes required were calculated (significance level: 95%; power: 80%), given effect sizes ranging from 6% to 14%, using both between and within-subject approaches. Results were considered statistically significant at P ≤ 0.05. Results: Bland–Altman plots showed negligible biases between test–retest sessions (MTR: 0.0009; MTsat: 0). ROI-based and voxel-wise CVs revealed high reproducibility for both MTR (ROI-bsCV/wsCV: CC—4.5/2.8%; IC—6.1/5.2%; HC—5.7/4.6%; CX—5.1/2.3%; TH—7.4/4.9%) and MTsat (ROI-bsCV/wsCV: CC—6.3/4.8%; IC—7.3/5.1%; HC—9.5/6.4%; CX—6.7/6.5%; TH—7.2/5.3%). With a sample size of 6, changes on the order of 15% could be detected in MTR and MTsat, both between and within subjects, while smaller changes (6%–8%) required sample sizes of 10–15 for MTR, and 15–20 for MTsat. Data Conclusion: MTsat exhibited comparable reproducibility to MTR, while providing sensitivity to myelin with less T1 dependence than MTR. Evidence Level: 2. Technical Efficacy: Stage 1

Mago Nashi, Tsunagi/Y14, and Ranshi form a complex that influences oocyte differentiation in Drosophila melanogaster

AbstractDuring Drosophila melanogaster oogenesis, a germline stem cell divides forming a cyst of 16 interconnected cells. One cell enters the oogenic pathway, and the remaining 15 differentiate as nurse cells. Although directed transport and localization of oocyte differentiation factors within the single cell are indispensible for selection, maintenance, and differentiation of the oocyte, the mechanisms regulating these events are poorly understood. Mago Nashi and Tsunagi/Y14, core components of the exon junction complex (a multiprotein complex assembled on spliced RNAs), are essential for restricting oocyte fate to a single cell and for localization of oskar mRNA. Here we provide evidence that Mago Nashi and Tsunagi/Y14 form an oogenic complex with Ranshi, a protein with a zinc finger-associated domain and zinc finger domains. Genetic analyses of ranshi reveal that (1) 16-cell cysts are formed, (2) two cells retain synaptonemal complexes, (3) all cells have endoreplicated DNA (as observed in nurse cells), and (4) oocyte-specific cytoplasmic markers accumulate and persist within a single cell but are not localized within the posterior pole of the presumptive oocyte. Our results indicate that Ranshi interacts with the exon junction complex to localize components essential for oocyte differentiation within the posterior pole of the presumptive oocyte

Using Participatory Scenarios to Stimulate Social Learning for Collaborative Sustainable Development

Interdependent human and biophysical systems are highly complex and behave in unpredictable and uncontrollable ways. Social and ecological challenges that emerge from this complexity often defy straightforward solutions, and efforts to address these problems will require not only scientific and technological capabilities but also learning and adaptation. Scenarios are a useful tool for grappling with the uncertainty and complexity of social-ecological challenges because they enable participants to build adaptive capacity through the contemplation of multiple future possibilities. Furthermore, scenarios provide a platform for social learning, which is critical to acting in the face of uncertain, complex, and conflict-laden problems. We studied the Minnesota 2050 project, a collaborative project through which citizens collectively imagined future scenarios and contemplated the implications of these possibilities for the adaptability of their social and environmental communities. Survey and interview data indicate that these participatory scenario workshops built and strengthened relationships, enhanced participants’ understanding of other perspectives, and triggered systemic thinking, all of which is relevant to collective efforts to respond to social-ecological challenges through sustainable development activities. Our analysis shows that participatory scenarios can stimulate social learning by enabling participants to engage and to discuss options for coping with uncertainty through collaborative actions. Such learning can be of value to participants and to the organizations and decisions in which they are engaged, and scenario processes can be effective tools for supporting collaborative sustainable development efforts

The prevalence and impact of adolescent hospitalization to adult psychiatric units.

BACKGROUND: With increasing psychiatric hospitalizations among adolescents and constrained hospital resources, there are times when youth are hospitalized in adult inpatient psychiatry units. Evidence on the prevalence of this practice and associated impacts is lacking. AIMS: We sought to explore the prevalence, determinants, and outcomes related to the hospitalization of adolescents aged 12-17 years on adult inpatient psychiatry units in Ontario. METHODS: Using health administrative data, we constructed a cohort of adolescents with an inpatient psychiatric admission in Ontario (2007-2011). We classified adolescents as having an admission to an adult psychiatry unit or to other inpatient units. Multivariable regression models were used to estimate prevalence ratios (PR) for factors associated with adult admission, as well as risk ratios (RR) for the impact of adult admission on length of stay, discharge against medical advice, and 30-day readmission. RESULTS: Over the study period, 22.6% of adolescents with a psychiatric hospitalization (n = 16 998) had an admission to an adult psychiatry unit. Older age (16 vs. 15 years: PR = 2.27, 95% CI = 2.07-2.48; 17 vs. 15 years: PR = 2.91, 95% CI = 2.66-3.18), rural residence (PR = 1.46, 95% CI = 1.38-1.55), psychotic (PR = 1.25, 95% CI = 1.15-1.36) or personality disorder (PR = 1.59, 95% CI = 1.41-1.80) diagnoses, and involuntary status (PR = 2.18, 95% CI = 2.05-2.31) were independently associated with adult admission. Adolescents admitted to adult units were more likely to be discharged against medical advice (RR = 1.77, 95% CI = 1.45-2.17). CONCLUSIONS: Nearly one in four adolescent psychiatric admissions occurs on an adult psychiatric unit. These findings help to fill gaps in the prior literature, and highlight the need for further research to inform policy decisions and resource allocation for adolescent inpatient psychiatric care

Identification of antisense nucleic acid hybridization sites in mRNA molecules with self-quenching fluorescent reporter molecules

We describe a physical mRNA mapping strategy employing fluorescent self-quenching reporter molecules (SQRMs) that facilitates the identification of mRNA sequence accessible for hybridization with antisense nucleic acids in vitro and in vivo, real time. SQRMs are 20–30 base oligodeoxynucleotides with 5–6 bp complementary ends to which a 5′ fluorophore and 3′ quenching group are attached. Alone, the SQRM complementary ends form a stem that holds the fluorophore and quencher in contact. When the SQRM forms base pairs with its target, the structure separates the fluorophore from the quencher. This event can be reported by fluorescence emission when the fluorophore is excited. The stem–loop of the SQRM suggests that SQRM be made to target natural stem–loop structures formed during mRNA synthesis. The general utility of this method is demonstrated by SQRM identification of targetable sequence within c-myb and bcl-6 mRNA. Corresponding antisense oligonucleotides reduce these gene products in cells

Concert recording 2012-10-10

[Track 01]. Concerto no. 2 after Vivaldi. Allegro / Johann Sebastian Bach ; arranged by Mordechai Rechtman -- [Track 02]. Concerto no. 2 after Vivaldi. Moderato / Johann Sebastian Bach ; arranged by Mordechai Rechtman -- [Track 03]. Concerto no. 2 after Vivaldi. Adagio / Johann Sebastian Bach ; arranged by Mordechai Rechtman -- [Track 04]. Divertimento. Allegro molto / Joseph Haydn ; arranged by Mordechai Rechtman -- [Track 05]. Divertimento. Menuetto I / Joseph Haydn ; arranged by Mordechai Rechtman -- [Track 06]. Divertimento. Adagio / Joseph Haydn ; arranged by Mordechai Rechtman -- [Track 07]. Divertimento. Menuetto II / Joseph Haydn ; arranged by Mordechai Rechtman -- [Track 08]. Divertimento. Presto assai / Joseph Haydn ; arranged by Mordechai Rechtman -- [Track 09]. Divertimento in E♭, KV 439b, no. 1. Allegro / W.A. Mozart ; arranged by Mordechai Rechtman -- [Track 10]. Divertimento in E♭, KV 439b, no. 1. Menuetto / W.A. Mozart ; arranged by Mordechai Rechtman -- [Track 11]. Divertimento in E♭, KV 439b, no. 1. Adagio / W.A. Mozart ; arranged by Mordechai Rechtman -- [Track 12]. Divertimento in E♭, KV 439b, no. 1. Menuetto / W.A. Mozart ; arranged by Mordechai Rechtman -- [Track 13]. Three songs from Des Knaben Wunderhorn. Rheinlegenchen / G. Mahler -- [Track 14]. Three songs from Des Knaben Wunderhorn. Wer hat liedel erdacht? / G. Mahler -- [Track 15]. Three songs from Des Knaben Wunderhorn. Lob des hohen Verstandes / G. Mahler -- [Track 16]. Sixtour. Risoluto / Jean Francaix -- [Track 17]. Sixtour. Andante / Jean Francaix -- [Track 18]. Sixtour. Scherzo / Jean Francaix -- [Track 19]. Sixtour. Andante / Jean Francaix -- [Track 20]. Sixtour. Risoluto / Jean Francaix -- [Track 21]. Encore

Is closing the agricultural yield gap a risky endeavor?

CONTEXT: Sub-Saharan Africa (SSA) has the climatic and biophysical potential to grow the crops it needs to meet rapidly growing food demand; however, agricultural productivity remains low. While potential maize yields in Zambia are 9 t per hectare (t/ha), the average farmer produces only 1–2. OBJECTIVE: We evaluate the contribution of responses to weather risk to that gap by decomposing the yield gap in maize in Zambia. While we know that improved seed and fertilizer can expand yield and profit, they may also increase the variance of yield under different weather outcomes, reducing their adoption. METHODS: We use a novel approach combining crop modeling and statistical analysis of survey data to obtain the yield gap components in Zambia driven by input cost and input risk. We use a crop model to simulate district-level marginal effects of fertilizer and seed maturity choice on the mean and variance of expected yield and profit under all-weather outcomes for each district for the past 30 years. We compare input levels that maximize expected yield to those that maximize expected profit and maximize the expected mean-variance trade-off assuming risk-aversion. To determine how much farmers\u27 input choices are made to reduce risk, we then quantify differences in the expected riskiness of inputs by district. RESULTS AND CONCLUSIONS: We find approximately one-quarter of the yield gap can be explained by risk-reducing behavior, albeit with a substantial geographic variation. Given this finding, under present conditions, we expect that the average maximum yield that farmers can obtain without increasing risk is 6.75 t/ha compared to a potential profit-maximizing level of 8.84 t/ha. SIGNIFICANCE: The risk-related yield gap is only expected to increase with weather extremes driven by climate change. Promoting “one-size-fits all” solutions to closing the yield gap could underestimate the effect of risk mitigation on agricultural production while increasing farmers\u27 risk exposure. © 2023 The Author