The Internet and the Strategies of Firms: Does Technological Orientation of the Firm Make a Difference?

Designed to track how growth of the Internet and the burst of the dot.com bubble might affect strategies of the firms, this study found that most respondents want to become more entrepreneurial and risk-taking when exploiting the opportunities afforded by the Internet. Based on the findings of the study, we note that firms that are more entrepreneurial will assimilate the Internet as a technology. The Internet is an enabling technology that provides a set of tools that could be used in any industry as part of a firm’s strategy, and the brick and mortar firms must integrate the Internet so as to enhance the distinctiveness of the strategy of the firm

Corporate Entrepreneurship in the Digital Era: The Cascading Effect through Operations

This study examines a firm’s response to perceived changes in the environment, such as the growth of the digital era, at different levels of a firm—beginning with the adoption of corporate entrepreneurship (CE) down to process renewal (PR). We further explore if the technological intensity of a firm, high-tech or low-tech intensity, influences its choice of mode for organisational renewal (OR)—use of internal competence or outside acquisition—to exploit the opportunities created by the digital era. Using survey data from 170 firms, we test a sequential relationship among environmental changes (growth of the digital era), CE, OR and finally PR that involves operating procedures at the functional level. We conclude by identifying the study’s interdisciplinary contributions, which open new research avenues in the field of CE

International Growth Strategies of Service and Manufacturing Firms: The Case of Banking and Chemical Industries

Purpose – The purpose of this paper is to examine the differences in growth strategies – domestic and international – of manufacturing and service firms. Hardly any literature exists that empirically investigates the differences on account of the distinctive characteristics of goods and services, and such studies rarely draw from the operations management field. Design/methodology/approach – Multiple analysis of variance is used to analyze longitudinal data from multiple secondary sources. Findings – Mixed services, such as banks, focus more on domestic growth and less on international growth. Manufacturers, such as chemical firms, focus more on international activities as compared to domestic activities. Mixed service firms seem to prefer collaborative approaches, whereas goods producers prefer wholly owned ventures. Research limitations/implications – The data collection methodology applied in this study may be applicable to many other topics of operations management. Future researchers may examine internationalization of services from front and back office perspectives, and compare information‐processing, possession‐processing, and people‐processing services in their choices of mode of entry and resultant performance differences. Practical implications – The findings are relevant for developing operations strategy, including location alternatives, for both manufacturing and service firms as different nations become a part of the global village. Appropriate modes of entry in an international arena for both service and manufacturing firms are identified. Originality/value – A cross‐functional study that uses longitudinal data from secondary sources in an innovative way with significant implications for operations managers and researchers

Interpretation of the Flavor Dependence of Nucleon Form Factors in a Generalized Parton Distribution Model

We give an interpretation of the $u$ and $d$ quarks contributions to the nucleon electromagnetic form factors for values of the four-momentum transfer in the multi-GeV region where flavor separated data have been recently made available. The data show, in particular, a suppression of $d$ quarks with respect to $u$ quarks at large momentum transfer. %and constant ratios of the flavor dependent Pauli to Dirac form factors ratios. This trend can be explained using a reggeized diquark model calculation of generalized parton distributions, thus providing a correlation between momentum and coordinate spaces, both of which are necessary in order to interpret the partonic substructure of the form factors. We extend our discussion to the second moments of generalized parton distributions which are believed to contribute to partonic angular momentum.Comment: 22 pages, 19 figures; results and figures added and changed, tables added, formulae added, major rewriting of tex

Organizational Alignment and Performance: Past, Present and Future

Purpose – The purpose of this paper is to identify and define the types of organizational alignment – vertical and horizontal; to examine the evidence for the alignment‐performance relationship, and propose research questions and practical implications to advance the theory and practice of managing alignment. Design/methodology/approach – The study is a conceptual examination based on a thorough review of both theoretical and empirical research. Findings – The paper finds that vertical alignment has received considerably more attention in the literature. Studies of horizontal alignment within organizations are less common. When horizontal alignment is studied, the focus tends to be dyadic – between two functional areas. The limitations posed by the dyadic approach suggest gaps in the research and opportunities for future research. As firms grow and diversify, becoming multi‐business organizations, the importance of horizontal alignment will be elevated. Research limitations/implications – Research on vertical alignment should focus on developing larger sets of moderating variables, such as the morale of the workforce, or the life cycle of the firm or industry. Research on horizontal alignment should explore multi‐point horizontal alignment. Practical implications – Managers in organizations with multiple strategic business units could use the application questions in the study to assess the state of alignment in their respective units and the organization as a whole. Originality/value – The paper documents existing literature on the concept of organizational alignment and identifies new opportunities to continue to build and expand the research stream. It also provides a list of application questions that may be used to assess organizational alignment in organizations

Experiential Learning Process: Exploring Teaching and Learning of Strategic Management Framework Through The Winter Survival Exercise

This article examines an attempt to introduce experiential learning methods in a business strategy course. In organizational behavior and industrial/organizational psychology, experiential teaching methods have been so widely adopted that some authors have suggested dropping the distinction between experiential and traditional teaching. Although intuitively appealing, experiential methods have not yet become popular among professors teaching strategy to traditional-age undergraduate students. It seems that heavy reliance on case-based teaching has resulted in a lack of emphasis on experiential learning tools for strategic management. In this study, the Winter Survival Exercise was used to introduce, concisely and effectively, the strategic management framework to 97 traditional-age undergraduate strategic management students in three different sections over three semesters. Statistical analysis supported the efficacy of this teaching method. Implications for teaching business strategy using experiential methods as a complement to rather than a substitute for traditional case studies are discussed

Sub-millisecond time-resolved SAXS using a continuous-flow mixer and X-ray micro-beam

Small-angle X-ray scattering (SAXS) is a well established technique to probe the nanoscale structure and interactions in soft matter. It allows one to study the structure of native particles in near physiological environments and to analyze structural changes in response to variations in external conditions. The combination of microfluidics and SAXS provides a powerful tool to investigate dynamic processes on a molecular level with sub-millisecond time resolution. Reaction kinetics in the sub-millisecond time range has been achieved using continuous-flow mixers manufactured using micromachining techniques. The time resolution of these devices has previously been limited, in part, by the X-ray beam sizes delivered by typical SAXS beamlines. These limitations can be overcome using optics to focus X-rays to the micrometer size range providing that beam divergence and photon flux suitable for performing SAXS experiments can be maintained. Such micro-SAXS in combination with microfluidic devices would be an attractive probe for time-resolved studies. Here, the development of a high-duty-cycle scanning microsecond-timeresolution SAXS capability, built around the Kirkpatrick–Baez mirror-based microbeam system at the Biophysics Collaborative Access Team (BioCAT) beamline 18ID at the Advanced Photon Source, Argonne National Laboratory, is reported. A detailed description of the microbeam small-angle-scattering instrument, the turbulent flow mixer, as well as the data acquisition and control and analysis software is provided. Results are presented where this apparatus was used to study the folding of cytochrome c. Future prospects for this technique are discussed

Functional recombinant antibodies against human chorionic gonadotropin expressed in plants

Single-chain variable fragments, diabodies and chimeric antibodies (mouse variable domains and human immunoglobulin constant domains) were engineered by DNA recombinant technique and expressed transiently in tobacco leaves. The plants expressed the three types of antigen-binding moieties, accurately and faithfully. The yield obtained was 32 mg, 40 mg and 20 mg respectively, per kg of wet weight of leaves. The chimeric antibody had high affinity for human chorionic gonadotropin (Ka=1.9×1010M−1). All three forms of the recombinant antibodies expressed by plants inhibited the binding of hCG to receptor on Leydig cells

Modulation of frustration in folding by sequence permutation

Folding of globular proteins can be envisioned as the contraction of a random coil unfolded state toward the native state on an energy surface rough with local minima trapping frustrated species. These substructures impede productive folding and can serve as nucleation sites for aggregation reactions. However, little is known about the relationship between frustration and its underlying sequence determinants. Chemotaxis response regulator Y (CheY), a 129-amino acid bacterial protein, has been shown previously to populate an off-pathway kinetic trap in the microsecond time range. The frustration has been ascribed to premature docking of the N- and C-terminal subdomains or, alternatively, to the formation of an unproductive local-in-sequence cluster of branched aliphatic side chains, isoleucine, leucine, and valine (ILV). The roles of the subdomains and ILV clusters in frustration were tested by altering the sequence connectivity using circular permutations. Surprisingly, the stability and buried surface area of the intermediate could be increased or decreased depending on the location of the termini. Comparison with the results of small-angle X-ray-scattering experiments and simulations points to the accelerated formation of a more compact, on-pathway species for the more stable intermediate. The effect of chain connectivity in modulating the structures and stabilities of the early kinetic traps in CheY is better understood in terms of the ILV cluster model. However, the subdomain model captures the requirement for an intact N-terminal domain to access the native conformation. Chain entropy and aliphatic-rich sequences play crucial roles in biasing the early events leading to frustration in the folding of CheY

The PROMISES study: A mixed methods approach to explore the acceptability of salivary progesterone testing for preterm birth risk among pregnant women and trained frontline healthcare workers in rural India

Introduction India has an overall neonatal mortality rate of 28/1000 live births, with higher rates in rural India. Approximately 3.5 million pregnancies in India are affected by preterm birth (PTB) annually and contribute to approximately a quarter of PTBs globally. Embedded within the PROMISES study (which aims to validate a low-cost salivary progesterone test for early detection of PTB risk), we present a mixed methods explanatory sequential feasibility substudy of the salivary progesterone test. Methods A pretraining and post-training questionnaire to assess Accredited Social Health Activists (ASHAs) (n=201) knowledge and experience of PTB and salivary progesterone sampling was analysed using the McNemar test. Descriptive statistics for a cross-sectional survey of pregnant women (n=400) are presented in which the acceptability of this test for pregnant women is assessed. Structured interviews were undertaken with ASHAs (n=10) and pregnant women (n=9), and were analysed using thematic framework analysis to explore the barriers and facilitators influencing the use of this test in rural India. Results Before training, ASHAs' knowledge of PTB (including risk factors, causes, postnatal support and testing) was very limited. After the training programme, there was a significant improvement in the ASHAs' knowledge of PTB. All 400 women reported the salivary test was acceptable with the majority finding it easy but not quick or better than drawing blood. For the qualitative aspects of the study, analysis of interview data with ASHAs and women, our thematic framework comprised of three main areas: implementation of intervention; networks of influence and access to healthcare. Qualitative data were stratified and presented as barriers and facilitators. Conclusion This study suggests support for ongoing investigations validating PTB testing using salivary progesterone in rural settings