Sustainable Fisheries & Coastal Zoning in Montserrat: Legal & Institutional Assessment of Authorities & Approaches

In February 2015, the Government of Montserrat and the Waitt Institute signed a memorandum of understanding to launch Blue Halo Montserrat, a comprehensive ocean and coastal management project with a goal of sustainable management of Montserrat's ocean and coastal waters. BHM seeks to develop a Montserrat Sustainable Ocean Policy that will ensure long-term health of Montserrat's waters through ocean zoning, protected areas, and fisheries reforms. This Report is an evaluation of Montserrat's laws and institutions to support the design and implementation of a comprehensive ocean zoning and management system in the country as part of the Blue Halo Initiative. The Report identifies existing authorities to achieve a comprehensive ocean zoning system in the waters surrounding Montserrat, evaluates potential options for ocean planning and management implementation, and provides recommendations for ways to develop a comprehensive ocean management system for Montserrat. The Report recognizes that comprehensive ocean management should build from the existing legal system, take pragmatic steps given anticipated capacity and funding, and provide effective incentives and requirements to ensure compliance and long-term sustainability of ocean resources

Nowhere Else to Turn: Key Findings from an Evaluation of the National Offenders’ Families Helpline

Children and families of offenders have been described as the ‘forgotten victims’ of the Criminal Justice System (CJS), and advocacy groups argue that criminal justice agencies pay insufficient attention to the impact of their processes on families, meaning that their best interests can be overlooked or actively damaged.1 This paper presents findings from an evaluation of the Offenders’ Families Helpline — a free and confidential service providing information, emotional support and signposting to families and friends of offenders involved in any stage of the CJS. In 2013, the Helpline received almost 10,000 telephone calls and over 145,000 unique visitors to its website. The Helpline is funded by the National Offender Management Service (NOMS), and at the time of the evaluation was delivered by Partners of Prisoners and Families Support Group (POPS), a voluntary sector organisation based in Manchester. The aims of the evaluation were to assess the extent to which the Helpline meets families’ support needs, and to evidence the impact and outcomes of the Helpline for family member

Visual Rulemaking

Federal rulemaking has traditionally been understood as a text-bound, technocratic process. However, as this Article is the first to uncover, rulemaking stakeholders—including agencies, the President, and members of the public—are now deploying politically tinged visuals to push their agendas at every stage of high-stakes, often virulently controversial, rulemakings. Rarely do these visual contributions appear in the official rulemaking record, which remains defined by dense text, lengthy cost-benefit analyses, and expert reports. Perhaps as a result, scholars have overlooked the phenomenon we identify here: the emergence of a visual rulemaking universe that is splashing images, GIFs, and videos across social media channels. While this new universe, which we call “visual rulemaking,” might appear to be wholly distinct from the textual rulemaking universe on which administrative law has long focused, the two are not in fact separate. Visual politics are seeping into the technocracy. This Article argues that visual rulemaking is a good thing. It furthers fundamental regulatory values, including transparency and political accountability. It may also facilitate participation by more diverse stakeholders—not merely regulatory insiders who are well-equipped to navigate dense text. Yet we recognize that visual rulemaking poses risks. Visual appeals may undermine the expert-driven foundation of the regulatory state, and some uses may threaten or outright violate key legal doctrines, including the Administrative Procedure Act and longstanding prohibitions on agency lobbying and propaganda. Nonetheless, we conclude that administrative law theory and doctrine ultimately can and should welcome this robust new visual rulemaking culture

Visual Rulemaking

Visual politics are seeping into the technocracy. Rulemaking stakeholders—including agencies, the President, and members of the public—are deploying politically tinged visuals to push their agendas at every stage of high-stakes, often virulently controversial, rulemakings. These images, GIFs, and videos usually do not make it into the official rulemaking record, so this new “visual rulemaking” world has not been discussed much by scholars or others. In this article, we explore the new visual rulemaking culture that emerged in Obama’s presidency, providing examples and discussing relevant policy implications. Although we recognize some risks, we argue that, on balance, visual rulemaking is a good thing because it can further transparency, accountability, and participation. Our article is adapted from a much longer one, Visual Rulemaking, 91 N.Y.U. L. Rev. 1183-1278 (2016)

Computational modeling of protein-protein and protein-peptide interactions

Protein-protein and protein-peptide interactions play a central role in various aspects of the structural and functional organization of the cell. While the most complete structural characterization is provided by X-ray crystallography, many biological interactions occur in complexes that will not be amenable to direct experimental analysis. Therefore, it is important to develop computational docking methods that start from the structures of component proteins and predict the structure of their complexes, preferably with accuracy close to that provided by X-ray crystallography. This thesis details three applications of computational protein modeling, including the study of antibody maturation mechanisms, and the development of protocols for peptide-protein interaction prediction and template-based modeling of protein complexes. The first project, a comparative analysis of docking an antigen structure to antibodies across a lineage, reveals insights into antibody maturation mechanisms. A linear relationship between near-native docking results and changes in binding free energy is established, and used to investigate changes in binding affinity following mutation across two antibody-antigen systems: influenza and anthrax. The second project demonstrates that a motif-based search of available protein crystal structures is sufficient to adequately represent the conformational space sampled by a flexible peptide, compared to that of a rigid globular protein. This observation forms the basis for a global peptide-protein docking protocol that has since been implemented into the Structural Bioinformatics Laboratory’s docking web server, ClusPro. Finally, as structure availability remains a roadblock to many studies, researchers turn to homology modeling, in which the desired protein sequence is modeled onto a related structure. This is particularly challenging when the target is a protein complex, further restricting template availability. To address this problem, the third project details the development of a new template-based modeling protocol to be integrated into the ClusPro server. The implementation of a novel template-based search enables users to model both homomeric and heteromeric complexes, greatly expanding ClusPro server functionality.2020-08-30T00:00:00

Approaches to Carrier Testing and Results Disclosure in Translational Genomics Research

Background: Clinical genome and exome sequencing (CGES) is primarily used to address specific clinical concerns by detecting risk of future disease, clarifying diagnosis, or directing treatment. Additionally, CGES makes possible the disclosure of autosomal recessive and X-linked carrier results as additional secondary findings, and research about the impact of carrier results disclosure in this context is needed. Methods: Representatives from 11 projects in the clinical sequencing exploratory research (CSER) consortium collected data from their projects using a structured survey. The survey focused on project characteristics, which variants were offered and/or disclosed to participants as carrier results, methods for carrier results disclosure, and project?specific outcomes. We recorded quantitative responses and report descriptive statistics with the aim of describing the variability in approaches to disclosing carrier results in translational genomics research projects. Results: The proportion of participants with carrier results was related to the number of genes included, ranging from 3% (three genes) to 92% (4,600 genes). Between one and seven results were disclosed to those participants who received any positive result. Most projects offered participants choices about whether to receive some or all of the carrier results. There were a range of approaches to communicate results, and many projects used separate approaches for disclosing positive and negative results. Conclusion: Future translational genomics research projects will need to make decisions regarding whether and how to disclose carrier results. The CSER consortium experience identifies approaches that balance potential participant interest while limiting impact on project resources

Fitting Problems Encountered by College Women Who Use Commercial Pants Patterns

Clothing, Textiles and Merchandisin