Predicted relative amount of Amelx protein in various murine Amelx transgenic and null strains.

<p>Predicted relative amount of Amelx protein in various murine Amelx transgenic and null strains.</p

Additional file 1: of Complex patterns of response to oral hygiene instructions: longitudinal evaluation of periodontal patients

Clinical, demographic, and genotyping data used in this study. (XLSX 49 kb

Mean enamel microhardness of 5-month old mice developed with variable amounts of amelogenin.

<p>Knockout mice (KO B6, KO C3H N5, KO Mix), which express no Amelx have “softer” enamel in comparison to the other strains (ANOVA; p<0.0001).</p

Mean enamel microhardness of 5-month old mice developed with variable amounts of amelogenin after the creation of an artificial caries lesion.

<p>The transgenic line Het C3H/B6 is more resistant to acid demineralization in comparison to knockout mice (KO B6, KO C3H N5, KO Mix) (ANOVA; p<0.0001).</p

Definitions of caries experience based on age and DMFT (Decayed, Missing due to caries, Filled Teeth) scores used in the Filipino families.

a<p>DMFT cut-offs were modified from the World Health Organization (World Health Organization, 2003),</p>b<p>Standard deviation.</p

Previously reported associations between enamel formation genes and caries susceptibility.

*<p>In the presence of <i>Streptococcus mutans</i>.</p>#<p>Only is less severely affected cases.</p

Family-based association test results for caries experience in Filipino familes.

<p>Statistically significant p-values (p<0.05) are presented in bold font.</p

Single marker association results for enamel microhardness.

<p>p-values <0.05 are presented in bold font.</p>*<p>Samples from buccal and lingual surfafes were analyzed together.</p><p>Artificial Caries/Baseline; The ratio of change for microhardness after creation of artificial caries.</p><p>Fluoride/Artificial Caries; The ratio of change for microhardness after fluoride treatment.</p><p>pH-cycling/Fluoride; The ratio of change for microhardness after pH-cycling treatment.</p

Demographics and caries experience of the replication study populations.

a<p>Decayed, Missing due to caries, Filled Teeth.</p>b<p>Standard deviation.</p>c<p>High and low caries experience was defined based on criteria 1 on <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0045022#pone-0045022-t001" target="_blank">Table 1</a>.</p

Correlations of enamel microhardness values in the several experimental points.

<p>Statistically significant correlations are presented in bold font.</p