492 research outputs found

    Brief of \u3cem\u3eAmicus Curiae\u3c/em\u3e Conference of Chief Justices in Support of Neither Party, Moore v. Harper, No. 21-1271 (U.S. Sept. 6, 2022)

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    Founded in 1949, amicus curiae Conference of Chief Justices (the “Conference”) is comprised of the Chief Justices or Chief Judges of the courts of last resort in all 50 states, the District of Columbia, the Commonwealths of Puerto Rico and the Northern Mariana Islands, and the Territories of American Samoa, Guam, and the Virgin Islands. For over 70 years, the Conference has been a leading national voice on important issues concerning the administration of justice in state courts, the operation of state courts and judicial systems, and the role of state courts in our federal system. The Conference files briefs amicus curiae only when critical interests of the state courts are at stake. This case involves the authority of state courts to interpret and review the constitutionality of state laws regulating the time, place, and manner of federal elections, and this Court’s resolution may determine the constraints, if any, that the U.S. Constitution places on such state-court review. The Conference has a strong interest in the States’ sovereign right to determine the structure of their state governments, including the authority of state courts and the role of state constitutions within that structure. The Conference recognizes that the States, including state courts, are limited by the U.S. Constitution, and the Conference has a significant interest in ensuring that those limits are properly interpreted to respect the independent sovereignty of the States; that state courts are the ultimate interpreters of the meaning of state law; and that power not expressly assigned to the federal government is “reserved to the States respectively, or to the people.” U.S. Const. amend. X. The Conference also has a keen interest in obtaining clear guidance from this Court about whether and to what extent the Elections Clause, U.S. Const. art. I, § 4, cl. 1, affects state courts’ capacity and responsibility to interpret state laws regulating federal elections and to engage in judicial review based on state constitutional provisions. This brief has been reviewed and approved by the Amicus Committee of the Conference, chaired by the Chief Justice of Kentucky, and composed of the current or former Chief Justices of Delaware, Indiana, Missouri, North Dakota, Texas, and Utah. The Conference does not take a position on the proper disposition of this case. Instead, it supports an interpretation of the Elections Clause that reflects the proper role of state courts in our federal system. Summary of argument: The Elections Clause does not bar state court review of state laws governing federal elections under state constitutional provisions

    Recent advances in the application of stable isotope ratio analysis in forensic chemistry

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    This review paper updates the previous literature in relation to the continued and developing use of stable isotope ratio analysis in samples which are relevant to forensic science. Recent advances in the analysis of drug samples, explosive materials, and samples derived from human and animal samples are discussed. The paper also aims to put the use of isotope ratio mass spectrometry into a forensic context and discuss its evidential potential

    Leading change in academic pharmacy: Report of the 2018-2019 aacp academic affairs committee

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    © 2019 by the authors. Licensee MDPI, Basel, Switzerland. Delivering an effective drug load to the posterior section of the ocular tissues, while using a non-invasive technique, has always been a challenge. In this regard, the goal of the present study was to develop sustained release triamcinolone acetonide (TA) loaded polymeric matrix films for ocular delivery. The TA-films were prepared in two different polymer matrices, with drug loadings of 10% and 20% w/w, and they were evaluated for ocular distribution in vivo in a conscious rabbit model. A 4% w/v TA suspension (TA-C) was used as a control for in vitro and in vivo studies. The TA-films, prepared with melt-cast technology, used polyethylene oxide (PEO) and Soluplus® as the polymer matrix. The films were evaluated with respect to assay, content uniformity, excipient interaction, and permeability across isolated rabbit sclera. The distribution of TA in the ocular tissues, post topical administration, was determined in New Zealand male albino rabbits as a function of dose, and was compared against TA-C. The assay of the 10% and 20% w/w film was in the range from 70–79% and 92–94% for the Soluplus® and PEO films, respectively, and content uniformity was in the range of 95–103% for both the films. The assay of the TA from Soluplus® films was less compared with the PEO films and showed an interaction with TA, as revealed by Differential Scanning Calorimetry (DSC). Hence, Soluplus® films were not selected for further studies. No interaction was observed between the drug and PEO polymer matrix. The enhancement of trans-scleral flux and permeability of TA was about 1.16 and 1.33-folds, respectively, from the 10% w/w PEO and 3.5 and 2.12-folds, respectively, from the 20% w/w PEO films, as compared with TA-C formulations. The in vivo studies demonstrate that significantly higher TA levels were observed in the anterior and posterior segments of the eye at the end of 6h with the PEO films. Therefore, the PEO based polymeric films were able to deliver TA into the back of the eye efficiently and for prolonged periods. View Full-Tex

    The Vehicle, December 1959, Vol. 1 no. 5

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    Vol. 1, No. 5 Table of Contents To The Readerpage 2 JudyRobert Mills Frenchpage 3 The FarmerRobert C. Millerpage 5 Bah! Humbug!The Skepticpage 5 Looking BackwardThe Optimistpage 7 Strangers in the TownAl Brookspage 7 Not Once OnlyA.B. Carterpage 8 OlogyRon Kellypage 8 SnowJean Nightingalepage 8 Moment of PowerJ.B. Youngpage 9 LifeRobert C. Millerpage 13 The Restless SeaRhonda McGowanpage 14 Approaching of the YuleRoger Perkinspage 14 The Old ModelMary Ellen Mockbeepage 15 \u27Tis the SeasonR.M.F.page 15 The Spirit of ChristmasKathleen Ferreepage 16 Christmas in the HeartKathleen Ferreepage 16 That\u27s BoysKathleen Ferreepage 16https://thekeep.eiu.edu/vehicle/1001/thumbnail.jp

    The Vehicle, April 1960, Vol. 2 no. 2

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    Vol. 2, No. 2 Table of Contents A White Man\u27s BurdenRobert Mills Frenchpage 2 RealistA.B. Carterpage 4 The Two MatchesLouise A. Kemperpage 5 Thought Upon Looking at a Modern Painting Titled Grass Thomas McPeakpage 7 BewareDennis Lewispage 7 WavesJean Nightingalepage 7 The SpectatorKathleen Ferreepage 8 Animal RugAl Brookspage 8 Success Comes to CulturevilleJ.B. Youngpage 9 On Giving Up Religion in DespairThe Skepticpage 11 The DecisionGeorge Fosterpage 12 Wisdom ConfoundedJames D. Rannepage 15 Smalltown: 5 A.M.James M. Jenkinsonpage 15 Man of MettleC.E.S.page 16https://thekeep.eiu.edu/vehicle/1005/thumbnail.jp

    The Vehicle, December 1959, Vol. 1 no. 5

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    Vol. 1, No. 5 Table of Contents To The Readerpage 2 JudyRobert Mills Frenchpage 3 The FarmerRobert C. Millerpage 5 Bah! Humbug!The Skepticpage 5 Looking BackwardThe Optimistpage 7 Strangers in the TownAl Brookspage 7 Not Once OnlyA.B. Carterpage 8 OlogyRon Kellypage 8 SnowJean Nightingalepage 8 Moment of PowerJ.B. Youngpage 9 LifeRobert C. Millerpage 13 The Restless SeaRhonda McGowanpage 14 Approaching of the YuleRoger Perkinspage 14 The Old ModelMary Ellen Mockbeepage 15 \u27Tis the SeasonR.M.F.page 15 The Spirit of ChristmasKathleen Ferreepage 16 Christmas in the HeartKathleen Ferreepage 16 That\u27s BoysKathleen Ferreepage 16https://thekeep.eiu.edu/vehicle/1001/thumbnail.jp

    The Vehicle, April 1960, Vol. 2 no. 2

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    Vol. 2, No. 2 Table of Contents A White Man\u27s BurdenRobert Mills Frenchpage 2 RealistA.B. Carterpage 4 The Two MatchesLouise A. Kemperpage 5 Thought Upon Looking at a Modern Painting Titled Grass Thomas McPeakpage 7 BewareDennis Lewispage 7 WavesJean Nightingalepage 7 The SpectatorKathleen Ferreepage 8 Animal RugAl Brookspage 8 Success Comes to CulturevilleJ.B. Youngpage 9 On Giving Up Religion in DespairThe Skepticpage 11 The DecisionGeorge Fosterpage 12 Wisdom ConfoundedJames D. Rannepage 15 Smalltown: 5 A.M.James M. Jenkinsonpage 15 Man of MettleC.E.S.page 16https://thekeep.eiu.edu/vehicle/1005/thumbnail.jp

    The Vehicle, October 1959, Vol. 1 no. 4

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    Vol. 1, No. 4 Table of Contents To the Reader and Acknowledgmentspage 2 SuccessFrank Pialorsipage 3 SeawardRobert C. Millerpage 7 High Precision SpeechNeil O. Parkerpage 8 ConvalescenceBarbara Wilson Dautpage 8 Has Anyone Seen Vinzetti?Robert Mills Frenchpage 9 WarR.M.F.page 10 Ode to My Math ProfessorsBud Bromleypage 11 Bird of PrayThe Skepticpage 11 DiscoveryRhonda McGowanpage 13 Solace For My DaughterAl Brookspage 14 Ownershippage 14 A Poetic GemGladys C. Winkleblackpage 14 I\u27ve Forgotten YouKathleen Ferreepage 15 Loading ZoneBert Bowderpage 15 Ode to An English Professorpage 15 To Be Read to a Driver Doing EightyA.B. Carterpage 16https://thekeep.eiu.edu/vehicle/1004/thumbnail.jp

    The Potential of Honey as a Prebiotic Food to Re-engineer the Gut Microbiome Toward a Healthy State

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    Honey has a long history of use for the treatment of digestive ailments. Certain honey types have well-established bioactive properties including antibacterial and anti-inflammatory activities. In addition, honey contains non-digestible carbohydrates in the form of oligosaccharides, and there is increasing evidence from in vitro, animal, and pilot human studies that some kinds of honey have prebiotic activity. Prebiotics are foods or compounds, such as non-digestible carbohydrates, that are used to promote specific, favorable changes in the composition and function of the gut microbiota. The gut microbiota plays a critical role in human health and well-being, with disturbances to the balance of these organisms linked to gut inflammation and the development and progression of numerous conditions, such as colon cancer, irritable bowel syndrome, obesity, and mental health issues. Consequently, there is increasing interest in manipulating the gut microbiota to a more favorable balance as a way of improving health by dietary means. Current research suggests that certain kinds of honey can reduce the presence of infection-causing bacteria in the gut including Salmonella, Escherichia coli, and Clostridiodes difficile, while simultaneously stimulating the growth of potentially beneficial species, such as Lactobacillus and Bifidobacteria. In this paper, we review the current and growing evidence that shows the prebiotic potential of honey to promote healthy gut function, regulate the microbial communities in the gut, and reduce infection and inflammation. We outline gaps in knowledge and explore the potential of honey as a viable option to promote or re-engineer a healthy gut microbiome
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