Herd Immunity: Does Social Media Affect Adherence to the CDC Childhood Vaccination Schedule?

Social Media can alter herd immunity by having a subtle yet pervasive impact on the adherence to the Childhood Vaccination Schedule recommended by the Center for Disease Control (CDC). Parents of children (newborn to young adults) utilize social media to acquire medical information such as the CDC’s Recommended Childhood Vaccination Schedule. Complying with anti-vaccination messages can result in parents not vaccinating their children, leading to a decline in the public’s herd immunity against known pathogens. However, there is a dearth of information about the possible impact of social media on herd immunity from childhood vaccination. Thus, this literature review will discuss the emerging themes from the current science in an effort to provide an initial understanding. In addition, the authors will provide a framework by which these themes demonstrate the ‘pitfalls’ of social media

Capturing and reporting topical treatment use in childhood eczema: lessons for data collection in eczema trials

BackgroundEmollients and topical corticosteroids (TCS) prevent and treat flares in eczema. However, topical treatment use is poorly recorded and reported in clinical trials. There is no clear consensus of how best to capture and summarise topical treatment use.ObjectivesTo explore different ways of capturing and reporting topical treatment use in childhood eczema.MethodsSecondary data analysis using 450 participants from the Best Emollients for Eczema (BEE) trial. Participants were allocated to use one type of emollient (lotion, cream, gel, or ointment) ‘twice daily and when required’ for 16 weeks. Otherwise, clinical management remained unchanged. Parents completed weekly questions about topical therapy use and eczema symptoms. Two versions of topical treatment use questionnaires were used. The first (n=202, 44.9%) asked parents to report treatment use on days 1-7, starting completion on the day they were randomised. The second (n=248, 55.1%) reported use by day of the week (Monday to Sunday), starting completion the first Monday after randomisation. Both underwent Patient and Public Involvement (PPI) review, but the second version was tested more thoroughly using cognitive interviewing techniques, following parent feedback that questions on the first version were confusing. Descriptive statistics compared questionnaire completion and differences in emollient and TCS use.ResultsOverall, questionnaire completion for both emollient and TCS use decreased with time: but at weeks 1 and 16 were 84.7% (381/450) and 58.9% (265/450) for emollient use, and 94.2% (424/450) and 80.4% (362/450) for TCS use, respectively. Fewer emollient use questionnaires were completed with first (33.5%) than the second (87.9%) version (p<0.001). TCS use questionnaire completion were similar for both (84.9% and 87.4%, p=0.002). We present different ways of summarising topical treatment use.ConclusionsWhile questionnaire completion was similar for TCS use, emollient use data completeness was higher in the second version. When designing questionnaires, balancing the detail and complexity of questions is important, especially if being collected as a secondary outcome measure. Numerous ways of summarising the same data can provide different information. Future collection and reporting of treatment use should reflect specific trial aims

Independent and combined effects of improved water, sanitation, and hygiene, and improved complementary feeding, on child stunting and anaemia in rural Zimbabwe: a cluster-randomised trial.

BACKGROUND: Child stunting reduces survival and impairs neurodevelopment. We tested the independent and combined effects of improved water, sanitation, and hygiene (WASH), and improved infant and young child feeding (IYCF) on stunting and anaemia in in Zimbabwe. METHODS: We did a cluster-randomised, community-based, 2 × 2 factorial trial in two rural districts in Zimbabwe. Clusters were defined as the catchment area of between one and four village health workers employed by the Zimbabwe Ministry of Health and Child Care. Women were eligible for inclusion if they permanently lived in clusters and were confirmed pregnant. Clusters were randomly assigned (1:1:1:1) to standard of care (52 clusters), IYCF (20 g of a small-quantity lipid-based nutrient supplement per day from age 6 to 18 months plus complementary feeding counselling; 53 clusters), WASH (construction of a ventilated improved pit latrine, provision of two handwashing stations, liquid soap, chlorine, and play space plus hygiene counselling; 53 clusters), or IYCF plus WASH (53 clusters). A constrained randomisation technique was used to achieve balance across the groups for 14 variables related to geography, demography, water access, and community-level sanitation coverage. Masking of participants and fieldworkers was not possible. The primary outcomes were infant length-for-age Z score and haemoglobin concentrations at 18 months of age among children born to mothers who were HIV negative during pregnancy. These outcomes were analysed in the intention-to-treat population. We estimated the effects of the interventions by comparing the two IYCF groups with the two non-IYCF groups and the two WASH groups with the two non-WASH groups, except for outcomes that had an important statistical interaction between the interventions. This trial is registered with ClinicalTrials.gov, number NCT01824940. FINDINGS: Between Nov 22, 2012, and March 27, 2015, 5280 pregnant women were enrolled from 211 clusters. 3686 children born to HIV-negative mothers were assessed at age 18 months (884 in the standard of care group from 52 clusters, 893 in the IYCF group from 53 clusters, 918 in the WASH group from 53 clusters, and 991 in the IYCF plus WASH group from 51 clusters). In the IYCF intervention groups, the mean length-for-age Z score was 0·16 (95% CI 0·08-0·23) higher and the mean haemoglobin concentration was 2·03 g/L (1·28-2·79) higher than those in the non-IYCF intervention groups. The IYCF intervention reduced the number of stunted children from 620 (35%) of 1792 to 514 (27%) of 1879, and the number of children with anaemia from 245 (13·9%) of 1759 to 193 (10·5%) of 1845. The WASH intervention had no effect on either primary outcome. Neither intervention reduced the prevalence of diarrhoea at 12 or 18 months. No trial-related serious adverse events, and only three trial-related adverse events, were reported. INTERPRETATION: Household-level elementary WASH interventions implemented in rural areas in low-income countries are unlikely to reduce stunting or anaemia and might not reduce diarrhoea. Implementation of these WASH interventions in combination with IYCF interventions is unlikely to reduce stunting or anaemia more than implementation of IYCF alone. FUNDING: Bill & Melinda Gates Foundation, UK Department for International Development, Wellcome Trust, Swiss Development Cooperation, UNICEF, and US National Institutes of Health.The SHINE trial is funded by the Bill & Melinda Gates Foundation (OPP1021542 and OPP113707); UK Department for International Development; Wellcome Trust, UK (093768/Z/10/Z, 108065/Z/15/Z and 203905/Z/16/Z); Swiss Agency for Development and Cooperation; US National Institutes of Health (2R01HD060338-06); and UNICEF (PCA-2017-0002)

Duration of androgen deprivation therapy with postoperative radiotherapy for prostate cancer: a comparison of long-course versus short-course androgen deprivation therapy in the RADICALS-HD randomised trial

Background Previous evidence supports androgen deprivation therapy (ADT) with primary radiotherapy as initial treatment for intermediate-risk and high-risk localised prostate cancer. However, the use and optimal duration of ADT with postoperative radiotherapy after radical prostatectomy remains uncertain. Methods RADICALS-HD was a randomised controlled trial of ADT duration within the RADICALS protocol. Here, we report on the comparison of short-course versus long-course ADT. Key eligibility criteria were indication for radiotherapy after previous radical prostatectomy for prostate cancer, prostate-specific antigen less than 5 ng/mL, absence of metastatic disease, and written consent. Participants were randomly assigned (1:1) to add 6 months of ADT (short-course ADT) or 24 months of ADT (long-course ADT) to radiotherapy, using subcutaneous gonadotrophin-releasing hormone analogue (monthly in the short-course ADT group and 3-monthly in the long-course ADT group), daily oral bicalutamide monotherapy 150 mg, or monthly subcutaneous degarelix. Randomisation was done centrally through minimisation with a random element, stratified by Gleason score, positive margins, radiotherapy timing, planned radiotherapy schedule, and planned type of ADT, in a computerised system. The allocated treatment was not masked. The primary outcome measure was metastasis-free survival, defined as metastasis arising from prostate cancer or death from any cause. The comparison had more than 80% power with two-sided α of 5% to detect an absolute increase in 10-year metastasis-free survival from 75% to 81% (hazard ratio [HR] 0·72). Standard time-to-event analyses were used. Analyses followed intention-to-treat principle. The trial is registered with the ISRCTN registry, ISRCTN40814031, and ClinicalTrials.gov , NCT00541047 . Findings Between Jan 30, 2008, and July 7, 2015, 1523 patients (median age 65 years, IQR 60–69) were randomly assigned to receive short-course ADT (n=761) or long-course ADT (n=762) in addition to postoperative radiotherapy at 138 centres in Canada, Denmark, Ireland, and the UK. With a median follow-up of 8·9 years (7·0–10·0), 313 metastasis-free survival events were reported overall (174 in the short-course ADT group and 139 in the long-course ADT group; HR 0·773 [95% CI 0·612–0·975]; p=0·029). 10-year metastasis-free survival was 71·9% (95% CI 67·6–75·7) in the short-course ADT group and 78·1% (74·2–81·5) in the long-course ADT group. Toxicity of grade 3 or higher was reported for 105 (14%) of 753 participants in the short-course ADT group and 142 (19%) of 757 participants in the long-course ADT group (p=0·025), with no treatment-related deaths. Interpretation Compared with adding 6 months of ADT, adding 24 months of ADT improved metastasis-free survival in people receiving postoperative radiotherapy. For individuals who can accept the additional duration of adverse effects, long-course ADT should be offered with postoperative radiotherapy. Funding Cancer Research UK, UK Research and Innovation (formerly Medical Research Council), and Canadian Cancer Society

P1851INCREASING CO-MORBIDITY REDUCES A PATIENT'S ABILITY TO SELF-MANAGE: AN OBSERVATIONAL STUDY IN NON-DIALYSIS CKD PATIENTS

Abstract Background and Aims Co-morbidity is high in CKD patients and associated with greater mortality and disease burden. Increased burden from other health conditions, as well as CKD, may impact the successful self-management of a patient’s health. A patient’s perceived ability to self-manage their condition can be assessed through the concept of ‘Patient Activation (PA)’ which encompasses a patient’s knowledge, skills, and confidence to undertake self-management tasks. Low PA is associated with poor self-reported health, greater renal impairment, and increased hospitalisation rates. Understanding PA may help the development and initiation of self-management interventions (e.g., low ‘activated’ individuals may require further education on their condition(s) whilst high ‘activated’ patients may require better support in maintaining their current lifestyle). This study aimed to assess how co-morbidity may influence PA and sought to identify which conditions, in exception to CKD, impact PA the most. This may help identify how co-morbidities affect patient’s ability self-manage successfully and aid the development of individualised intervention. Method The Patient Activation Measure (PAM), a validated 13 item questionnaire, assessed patient activation by measuring patients perceived ability to self-manage their condition. Results categorise participants into four activation categories (1 to 4; low to high). 152 non-dialysis CKD patients (52.6% female, age 67.9 (SD:12.7) years, eGFR 42.2 (SD:18.6) ml/min) provided self-reported information about their co-morbidities, and completed the PAM. Data was analysed by general linear modelling adjusting for age, sex and eGFR. Results 134/152 (88.2%) of patients were multi-morbid, defined as 2 or more conditions including CKD, with a mean of 2.1 (SD:1.4) comorbidities. Increasing co-morbidities were associated with reduced PAM score (p=0.009). PAM scores decreased from 67.96 (SE:3.68) in patients with no other co-morbidities to 55.57 (SE:2.81) with 4+ co-morbidities; a reduction from PA level 4 (high) to 2 (low) respectively. The co-morbidities which explained the largest variance in PAM score were diabetes (β=-.193, p=.021), respiratory conditions (β=-.184, p=.37), and MSK conditions (β=-.154, p=.081). No other conditions were predictive of PAM score. Conclusion Co-morbidity in non-dialysis CKD patients is high and is associated with reduced PA (i.e. the perceived ability of patients to self-manage their condition(s)). We identified that CKD patients with diabetes, respiratory, and musculoskeletal conditions found it more difficult to self-manage their co-existing conditions. Individuals with musculoskeletal or respiratory conditions may perceive poor self-management ability due to this conditions impact on function (e.g. physical activity limitations) and/or quality of life (e.g. symptoms or sleep). Diabetes could challenge perceived self-management ability due to its chronicity, management complexity (e.g. medication regimens and side effects) and demoralising health sequelae (e.g. cardiovascular risk). </jats:sec

Does an Association Exist Between Food Insecurity and Eating Disorder Symptoms Among Young People Living in England?

Food insecurity is defined as lacking regular access to nutritious food which sustains normal development and an active and healthy life (1). There is growing concern about the rising number of families affected by food insecurity in the United Kingdom (UK), and the implications of this for child and adolescent health, and social functioning (2-4). Evidence has demonstrated increased bingeing and fasting behaviours in adults (5, 6) and university students (7-9) affected by food insecurity. However, it is unclear whether such an association exists in adolescents. A 2023 systematic review published in April 2023 indicated a relationship between food insecurity and disordered eating behaviours in young people. This association varied depending on the type of disordered eating behaviour assessed and food insecurity severity (10). The review included 19 studies from the United States (US) and one from Bangladesh. To our knowledge, however, there are no studies exploring these associations in a UK setting. Given the differences in sociocultural norms, eating habits, and the health and social care systems between the US and the UK, this remains a pertinent issue to explore. This study aims to investigate the association between food insecurity and eating disorder symptomatology, including weight concerns, body shape concerns, and fasting and bingeing behaviours, in a large and diverse sample of young people in the UK

Does an Association Exist Between Food Insecurity and Eating Disorder Symptoms Among Young People Living in England?

Aims Food insecurity, defined as lacking regular access to nutritious food due to financial hardship, is associated with a range of adverse developmental outcomes for children and adolescents. Emerging evidence suggests food insecurity in adults may be associated with disordered eating behaviours, including binge eating and unhealthy weight control strategies. However, the nature of this relationship in adolescents remains unclear. This study aimed to investigate whether an association exists between food insecurity and eating disorder symptomatology in a large and diverse sample of adolescents living in England. Methods Cross-sectional data were collected from 34,730 young people in school years 7 to 13 (aged 11 to 18) in classrooms across England, as part of the OxWell 2023 Student Survey. Eating Disorder symptomatology was measured, on a scale of 0 to 6, with five self-report screening questions from the Eating Disorder Section of the Development and Well-Being Assessment (DAWBA) and one additional question on meal skipping due to shape/weight concerns. Food insecurity was measured, on a scale of 0 to 6, with three questions adapted from the Wales Young People's Survey on Child & Family Poverty 2019. A complete case analysis was conducted using Stata, v18. Regression analyses were performed to test for associations between food insecurity and eating disorder symptomatology, stratified by gender and adjusting for age and ethnicity. Results 12,571 (36.2%) participants were excluded due to missing data in key study variables. Our final sample comprised 22,159 adolescents with a mean age of 13.8 years (50.8% female, 54.4% white ethnicity). 63.6% of participants reported experiencing at least one eating disorder symptom and 45.7% scored ≥2 on the DAWBA screening items, a more stringent cut-off for possible eating disorder. Food insecurity was found to be a significant predictor of eating disorder symptomatology in participants of all genders (female: β 0.54, 95% CI 0.48–0.60, p < 0.001, male: β 0.40, 95% CI 0.36–0.44, p < 0.001, other: β 0.52, 95% CI 0.43–0.61, p < 0.001). The association was particularly marked amongst those reporting purging behaviours (OR 1.62, 95% CI 1.55–1.69, p < 0.001). Conclusion In keeping with previous research, our findings indicate that adolescents experiencing food insecurity exhibit increased rates of eating disorder symptomatology. Further research is needed to explore potential mechanisms behind this association, as well as to develop effective intervention strategies. Our study adds to a body of evidence identifying a high-risk and disenfranchised group of young people who may benefit from targeted support

A qualitative exploration of the facilitators and barriers to self-management in kidney transplant recipients

Abstract Background Understanding the behaviours that facilitate or impede one’s ability to self-manage is important to improve health-related outcomes in kidney transplant recipients (KTRs). Previous studies exploring the self-management experiences of KTRs have focused on specific tasks (e.g., medication adherence), age groups (e.g., adolescent or older recipients), or have been conducted outside of the UK where transferability of findings is unknown. Our study aimed to explore the perceptions and experiences of self-management in UK KTRs to identify facilitators and barriers associated with self-management tasks. Methods Semi-structured interviews were conducted with eleven KTRs. Topics explored included experiences of self-management tasks (diet, exercise, medications, stress management), perceived healthcare role, and future interventional approaches. Thematic analysis was used to identify and report themes. Results Eight themes were identified which were mapped onto the three self-management tasks described by Corbin and Strauss: medical, role and emotional management. Perceived facilitators to self-management were: gathering health-related knowledge, building relationships with healthcare professionals, creating routines within daily life, setting goals and identifying motivators, establishing support networks, and support from family and friends. Complexity of required treatment and adjusting to a new health status were perceived barriers to self-management. Conclusions Participants described the importance of collaborative consultations and continuity of care. Tailored interventions should identify individualised goals and motivators for participating in self-management. Education on effective strategies to manage symptoms and comorbidities could help alleviate KTRs’ perceived treatment burden. Family and peer support could emotionally support KTRs; however, managing the emotional burden of transplantation warrants more attention. Graphic abstract </jats:sec