1 research outputs found
Dynamic Ligand Exchange as a Mechanistic Probe in Pd-Catalyzed Enantioselective C–H Functionalization Reactions Using Monoprotected Amino Acid Ligands
A new tool for probing enantioselective
reaction mechanisms is
introduced. Monitoring the temporal change in product enantiomeric
excess after addition of the opposite enantiomer of the ligand during
the reaction provides a means of probing dynamic ligand exchange in
enantioselective C–H iodination catalyzed by Pd with monoprotected
amino acid ligands (MPAAs). This work has general potential to provide
insights about the dynamics of catalyst and ligand molecularity and
exchange