7 research outputs found
Association between gene score and outcome in the Pakistani samples.
<p>Logistic regression was performed for each group. (A) Islamabad study, outcome is MI, and (B) Lahore study, outcome is CHD. Error bars represent 95% confidence intervals.</p
Baseline Characteristics of NPHSII participants.
<p>All variable are present as the mean plus standard deviation, apart from the Framingham 10 year CHD risk score where the mean and interquartile range are given.</p><p>Baseline Characteristics of NPHSII participants.</p
Comparison of risk allele frequencies between the control groups from the Pakistani studies and between the combined total of the Pakistani control groups and NPHSII.
<p>Comparisons were performed using tests of proportion. RAF = Risk Allele Frequency, CI = Confidence Interval.</p><p>Comparison of risk allele frequencies between the control groups from the Pakistani studies and between the combined total of the Pakistani control groups and NPHSII.</p
Association between gene score and CHD in NPHSII.
<p>Logistic regression (age adjusted) was performed for each group. Error bars represent 95% confidence intervals.</p
Reclassification of NPHSII participants with the addition of the gene scores to the Framingham conventional risk factor score.
<p>NRI = net reclassification index.</p><p>Reclassification of NPHSII participants with the addition of the gene scores to the Framingham conventional risk factor score.</p
Characteristics of the Pakistani sample sets.
<p>Categorical variables were compared using a χ<sup>2</sup> test while continuous variables were compared using Welch’s t-tests.</p><p>* Log transformed data. Geometric mean and approximate SD are given.</p><p>Characteristics of the Pakistani sample sets.</p
SNPs included in the gene scores.
<p>SNPs marked with an asterisk (*) are included in both the 19 and 13 SNP gene score.</p><p><sup>+</sup>rs599839 was genotyped instead of rs646776, r<sup>2</sup> = 0.95 in Europeans</p><p><sup>++</sup>For rs7412, the protective SNP is included in the gene score</p><p>SNPs included in the gene scores.</p