Kidney burden of mice with disseminated aspergillosis treated with AMB-NPs, AMB deoxycholate, and Posaconazole 101 hours post infection (Panel A).

<p>Geometric mean tissue burdens (and standard deviations) of mice with disseminated aspergillosis treated with AMB-NPs, AMB deoxycholate, and Posaconazole 101 hours post infection (<b>Panel B</b>). The p values are from a Kruskal Wallis test (Conover-Inman).</p

The effect of solvent composition (DMSO:acetone) on particle size, entrapment efficiency (A) and particle size distribution (B).

<p>For all the preparations, PDI is 0.1±0.01.</p

The effect of initial AMB loading on particle size, entrapment efficiency (A) and particle size distribution (B).

<p>PDI for 10% Loading: 0.1±0.01; 20%: 0.2±0.00; 30%: 0.2±0.01.</p

The effect of non-solvent composition on particle size, entrapment efficiency (A) and particle size distribution (B).

<p>PDI, water: 0.3±0.1; 50% ethanol 0.1±0.07; ethanol 0.1±0.02.</p

Lung burden of mice with invasive pulmonary aspergillosis treated with AMB-NPs, AMB deoxycholate, AmBisome and Posaconazole 101 hours post infection (Panel A).

<p>Geometric mean tissue burdens (and standard deviations) of mice with invasive pulmonary aspergillosis treated with AMB-NPs, AMB deoxycholate, AmBisome and Posaconazole 101 hours post infection (<b>Panel B</b>). The p values are from a Kruskal Wallis test (Conover-Inman).</p

Libyan map showing the collection points Libyan Propolis samples P1 (Alagoria), P2 (Gaminis), P3 (Byda), P4 (Quba), P5,P6, P7 (Kufra), P8(Ghadames), P9 (Tripoli), P10 (Khasr Khiar), P11, P12 (Khumas).

<p>Libyan map showing the collection points Libyan Propolis samples P1 (Alagoria), P2 (Gaminis), P3 (Byda), P4 (Quba), P5,P6, P7 (Kufra), P8(Ghadames), P9 (Tripoli), P10 (Khasr Khiar), P11, P12 (Khumas).</p

Activity of samples P1-P12 against <i>P</i>.<i>falciparum</i> (n = 3).

<p>Activity of samples P1-P12 against <i>P</i>.<i>falciparum</i> (n = 3).</p

PCA with HCA based on the 300 most intense features obtained in negative ion mode for the 12 propolis samples R²X 0.689, Q² 0.48.

<p>PCA with HCA based on the 300 most intense features obtained in negative ion mode for the 12 propolis samples R²X 0.689, Q² 0.48.</p

Most important variables determining the activity of P2 in anti-protozoal and anti-microbial tests and important variables determining cellular toxicity based on sample P8 which was the most cytotoxic sample.

<p>Most important variables determining the activity of P2 in anti-protozoal and anti-microbial tests and important variables determining cellular toxicity based on sample P8 which was the most cytotoxic sample.</p

OPLS plot of observed against predicted activity against <i>P</i>. <i>falciparum</i> based on five compounds (A-E).

<p>OPLS plot of observed against predicted activity against <i>P</i>. <i>falciparum</i> based on five compounds (A-E).</p