494 research outputs found
Cooling curves for neutron stars with hadronic matter and quark matter
The thermal evolution of isothermal neutron stars is studied with matter both
in the hadronic phase as well as in the mixed phase of hadronic matter and
strange quark matter. In our models, the dominant early-stage cooling process
is neutrino emission via the direct Urca process. As a consequence, the cooling
curves fall too fast compared to observations. However, when superfluidity is
included, the cooling of the neutron stars is significantly slowed down.
Furthermore, we find that the cooling curves are not very sensitive to the
precise details of the mixing between the hadronic phase and the quark phase
and also of the pairing that leads to superfluidity.Comment: 19 pages, 25 figure
Collimated, single-pass atom source from a pulsed alkali metal dispenser for laser-cooling experiments
We have developed an improved scheme for loading atoms into a magneto-optical
trap (MOT) from a directed alkali metal dispenser in < 10^-10 torr ultra-high
vacuum conditions. A current-driven dispenser was surrounded with a cold
absorbing "shroud" held at < 0 C, pumping rubidium atoms not directed into the
MOT. This nearly eliminates background alkali atoms and reduces the detrimental
rise in pressure normally associated with these devices. The system can be
well-described as a current-controlled, rapidly-switched, two-temperature
thermal beam, and was used to load a MOT with 3 x 10^8 atoms.Comment: 5 pages, 4 figure
Generation of Functional CLL-Specific Cord Blood CTL Using CD40-Ligated CLL APC
PMCID: PMC3526610This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
The simulation of the activity dependent neural network growth
It is currently accepted that cortical maps are dynamic constructions that
are altered in response to external input. Experience-dependent structural
changes in cortical microcurcuts lead to changes of activity, i.e. to changes
in information encoded. Specific patterns of external stimulation can lead to
creation of new synaptic connections between neurons. The calcium influxes
controlled by neuronal activity regulate the processes of neurotrophic factors
released by neurons, growth cones movement and synapse differentiation in
developing neural systems. We propose a model for description and investigation
of the activity dependent development of neural networks. The dynamics of the
network parameters (activity, diffusion of axon guidance chemicals, growth cone
position) is described by a closed set of differential equations. The model
presented here describes the development of neural networks under the
assumption of activity dependent axon guidance molecules. Numerical simulation
shows that morpholess neurons compromise the development of cortical
connectivity.Comment: 10 pages, 2 figure
Fabrication and heating rate study of microscopic surface electrode ion traps
We report heating rate measurements in a microfabricated gold-on-sapphire
surface electrode ion trap with trapping height of approximately 240 micron.
Using the Doppler recooling method, we characterize the trap heating rates over
an extended region of the trap. The noise spectral density of the trap falls in
the range of noise spectra reported in ion traps at room temperature. We find
that during the first months of operation the heating rates increase by
approximately one order of magnitude. The increase in heating rates is largest
in the ion loading region of the trap, providing a strong hint that surface
contamination plays a major role for excessive heating rates. We discuss data
found in the literature and possible relation of anomalous heating to sources
of noise and dissipation in other systems, namely impurity atoms adsorbed on
metal surfaces and amorphous dielectrics.Comment: 17 pages, 5 figure
Down syndrome and postoperative complications after paediatric cardiac surgery: a propensity-matched analysis
OBJECTIVESThe incidence of congenital heart disease is approximately 50%, mostly related to endocardial cushion defects. The aim of our study was to investigate the postoperative complications that occur after paediatric cardiac surgery.METHODSOur perioperative data were analysed in paediatric patients with Down syndrome undergoing cardiac surgery. We retrospectively analysed the data from 2063 consecutive paediatric patients between January 2003 and December 2008. After excluding the patients who died or had missing data, the analysed database (before propensity matching) contained 129 Down patients and 1667 non-Down patients. After propensity matching, the study population comprised 222 patients and 111 patients had Down syndrome.RESULTSBefore propensity matching, the occurrences of low output syndrome (21.2 vs 32.6%, P = 0.003), pulmonary complication (14 vs 28.7%, P < 0.001) and severe infection (11.9 vs 22.5%, P = 0.001) were higher in the Down group. Down patients were more likely to have prolonged mechanical ventilation [median (interquartile range) 22 (9-72) h vs 49 (24-117) h, P = 0.007]. The total intensive care unit length of stay [6.9 (4.2-12.4) days vs 8.3 (5.3-13.2) days, P = 0.04] and the total hospital length of stay [17.3 (13.3-23.2) days vs 18.3 (15.1-23.6) days, P = 0.05] of the Down patients were also longer. Mortality was similar in the two groups before (3.58 vs 3.88%, P = 0.86) and after (5.4 vs 4.5%, P = 1.00) propensity matching. After propensity matching, there was no difference in the occurrence of adverse events.CONCLUSIONSAfter propensity matching Down syndrome was not associated with increased mortality or complication rate following congenital cardiac surgery
EBV-gp350 Confers B-Cell Tropism to Tailored Exosomes and Is a Neo-Antigen in Normal and Malignant B Cells—A New Option for the Treatment of B-CLL
gp350, the major envelope protein of Epstein-Barr-Virus, confers B-cell tropism to the virus by interacting with the B lineage marker CD21. Here we utilize gp350 to generate tailored exosomes with an identical tropism. These exosomes can be used for the targeted co-transfer of functional proteins to normal and malignant human B cells. We demonstrate here the co-transfer of functional CD154 protein on tailored gp350+ exosomes to malignant B blasts from patients with B chronic lymphocytic leukemia (B-CLL), rendering B blasts immunogenic to tumor-reactive autologous T cells. Intriguingly, engulfment of gp350+ exosomes by B-CLL cells and presentation of gp350-derived peptides also re-stimulated EBV-specific T cells and redirected the strong antiviral cellular immune response in patients to leukemic B cells. In essence, we show that gp350 alone confers B-cell tropism to exosomes and that these exosomes can be further engineered to simultaneously trigger virus- and tumor-specific immune responses. The simultaneous exploitation of gp350 as a tropism molecule for tailored exosomes and as a neo-antigen in malignant B cells provides a novel attractive strategy for immunotherapy of B-CLL and other B-cell malignancies
- …