4 research outputs found
Cooperative Binding of 1Phenylimidazole to Cobalt(II) Octaethylporphyrin on Graphite: A Quantitative Imaging and Computational Study at Molecular Resolution
Iron Oxide Surface Chemistry: Effect of Chemical Structure on Binding in Benzoic Acid and Catechol Derivatives
The excellent performance
of functionalized iron oxide nanoparticles
(IONPs) in nanomaterial and biomedical applications often relies on
achieving the attachment of ligands to the iron oxide surface both
in sufficient number and with proper orientation. Toward this end,
we determine relationships between the ligand chemical structure and
surface binding on magnetic IONPs for a series of related benzoic
acid and catechol derivatives. Ligand exchange was used to introduce
the model ligands, and the resultant nanoparticles were characterized
using Fourier transform infrared–attenuated internal reflectance
spectroscopy, transmission electron microscopy, and nanoparticle solubility
behavior. An in-depth analysis of ligand electronic effects and reaction
conditions reveals that the nature of ligand binding does not solely
depend on the presence of functional groups known to bind to IONPs.
The structure of the resultant ligand–surface complex was primarily
influenced by the relative positioning of hydroxyl and carboxylic
acid groups within the ligand and whether or not HClÂ(aq) was added
to the ligand-exchange reaction. Overall, this study will help guide
future ligand-design and ligand-exchange strategies toward realizing
truly custom-built IONPs