Apolipoprotein E genetic variation and statin therapy appointment

Dyslipidemia is an important risk factor for cardiovascular disease due to the significant influence of cholesterol on atherosclerosis. Several genetic variants in genes related with triglyceride (TG) metabolism has been described, including LPL, apolipoprotein A5 and apolipoprotein E (Apo E) are associated with dyslipidemia by involvement to lipid metabolism. The combined analysis of these polymorphisms could produce clinically meaningful complementary information. Changes in TG levels are now considered an independent cardiovascular risk factor; hence, the study of combined variants in genes involved in TG metabolism may help explain part of the risk for CVD. The most informative polymorphisms within the Apo E gene are the Arg158Cys (rs7412) and Cys112Arg (rs429358) which define Apo E gene alleles, epsilon2, 3 and 4 (£2, £3 and £4)

Thermodynamic and electrophysical properties of nanosized cobalt-cuprate-manganite and nickelite-cuprate-manganite oxides

Cobalt-cuprate-manganite LaCaCoCuMnO6 and nickelite-cuprate-manganite LaCaNiCuMnO6 oxides, were synthesized with ceramic processing technology from calcium carbonate and oxides of La(III), Co(II), Ni(II), Cu(II) and Mn(III). The nanodimensional particles were received with the milling at Retsch (Germany). The experimental and calculation methods determined their thermodynamic and electrophysical characteristics

Development of neural network models for the analysis of infocommunication traffic

This article discusses the problems of today’s infocommunication networks, the basis of which are multiservice networks serving all types of traffic, presented as a set of IP packets. The characteristic features of this traffic are analyzed, each of which is oriented to a certain class of services. The knowledge gained as a result of ongoing traffic research is an essential factor for increasing the effectiveness of decisions made in various fields of the telecommunications industry. The need for knowledge of the nature of traffic circulating in the network and the laws of its behavior is revealed and substantiated. Without this, it is impossible to effectively manage networks, develop solutions for their development, ensure network security and maintain the required level of quality. Despite the large number of works about building multi - service networks, a number of issues require further study. Analysis of traffic studies of modern converged, multiservice networks showed the lack of knowledge about its nature and laws of behavior, given the high variability of its characteristics. Thus, it can be argued that the parameters of the studied traffic are statistical, probabilistic in nature, can vary randomly over time and, accordingly, based on the study, the author proposes a study using statistical analysis methods. To study traffic, you should use the tools of probability theory and mathematical statistics

Calculation of thermodynamic properties of earth metals − copper-zinc (Cu-Zn)

The approximate methods calculated the standard thermodynamic characteristics of our new obtained copper-zinc manganites of compositions of LaMeI2CuZnMnO6 and LaMeIICuZnMnO6 (MeI − Li, Na, K; MeII – Mg, Ca, Sr, Ba)

Zoning of the Territory of the Republic of Kazakhstan by the Degree of Intensity of the Epizootic Situation on Plague in Camels

The aim of the study was to improve epizootiological monitoring and increase the effectiveness of preventive (anti-epidemic) measures for camel plague control in Kazakhstan.Materials and methods. We used the data on epizootiological and epidemiological monitoring in natural plague foci of Kazakhstan, long-term measurements and indicators for the period of 2000–2020 of the anti-plague and veterinary services of the Republic for the analysis. To process the evidence, epidemiological, epizootiological, microbiological, and statistical research methods, as well as GIS technology were applied.Results and discussion. The number of camels has increased by 2.2 times in Kazakhstan over the past 20 years.  Where there were 98.2 thousand heads in 2000, it amounted to 216.4 thousand heads in 2020. Over the past 10 years, 152 camels died of unknown causes in the focal area of the country, but laboratory tests for plague turned out negative. According to the hazard criteria, the territory of the country has been conditionally divided into three zones: five regions with a high degree of hazard with a total area of 953.15 sq. km, five regions with medium degree of hazard with a total area of 1230.72 sq. km, and with a low degree of hazard – four regions and three cities of republican significance with a total area of 541.1 sq. km. Constant epizootiological monitoring over plague in camels is a necessity for the system of preventive measures

INVESTIGATION OF THE PROCESS OF FERMENTATION OF CAMEL MILK VARIOUS TYPES OF LACTOBACILLI AND BIFIDUS BACTERIAS

Formation of probiotic properties of dairy products depends largely on the composition of the macrobiotic of ferment, so studies are necessary for the selection of specific strains of bacteria producing a complex of biologically active substances and enzymes. The first phase of research is to study the morphological, physiological and biochemical production and properties of different strains of lactic acid bacteria exhibited in fat-containing dairy environment. Main basic raw material for the production of fermented milk product is developed camel milk with different fat-contents. High nutritional and biological value of camel milk, as well as the best of their digestibility compared with other types of milk will create a product that meets the physiological needs of the body\u27s essential nutrients and energy. In the manufacture of probiotic dairy products functionality greatest attention must be paid to bifidus bacterias and lactobacilli as main representatives of the normal intestinal microflora, providing high colonization resistance of the intestinal tract and increases the activity of the organism`s immunomodulatory

DETERMINING THE INFLUENCE OF THE NANOPARTICLES ON THE GROWTH AND GENERATION OF LACTIC ACID BACTERIA

Nanotechnology "nano" (from the Greek. Seq. "Dwarf") is used in the terminology to describe longitudinal units equal to one billionth of from 1m (1nm = 10-9m). Nanotechnology, nanoscience, the science and technology of colloidal systems, colloid chemistry, colloid physics, molecular biology, all microelectronics, the fundamental differences between colloidal systems, which include: clouds, human blood, DNA and proteins, transistors, which they are going to microprocessors, is that the surface of these particles or molecules in the vast millions of times greater than the volume of the particles, such particles occupy an intermediate position between the true homogeneous solutions, alloys, and ordinary objects macrocosm. The behavior of such systems is very different from the behavior of true solutions and melts and macrocosm of the objects through the high surface usually such effects begin to play a significant role when the particle size is in the range of 1-200 nanometers, hence it word substitution colloidal physics, chemistry, biology on nanoscience and nanotechnology, meaning the size of the objects in question