FORECASTING AND GROUNDING OF HYGIENIC NORMS FOR INDUSTRIAL AND ATMOSPHERIC POLLUTENTS (AS AN EXAMPLE OF BENZOL AMINO-AND NITRODERIVATIVES)

The aim of the work is to improve the hygienic norming of the industrial and atmospheric pollutents on base of the studying specific action and forecasting effects of the toxicometric parameters. The approaches to improve the methodical approaches for hygienic norming of the benzol amino- and nitroderivatives have been shown on base of studying specific effects of the action and mathematical forecasting. The hygienic norms and methodical recommendations on forecasting biological action of the benzol amino- and nitroderivatives have been developed and introducedAvailable from VNTIC / VNTIC - Scientific & Technical Information Centre of RussiaSIGLERURussian Federatio

Hematologic Parameters Post Gastrointestinal Radiation Injury [Mean (SD); (n = 4)].

<p>Hematologic Parameters Post Gastrointestinal Radiation Injury [Mean (SD); (n = 4)].</p

Intestinal Cytokine levels (pg/mg protein) Post Gastrointestinal Radiation Injury [Mean (SD); (n = 4)].

<p>Intestinal Cytokine levels (pg/mg protein) Post Gastrointestinal Radiation Injury [Mean (SD); (n = 4)].</p

Organ Related Markers and Functional Test [Mean (SD); (n = 4 or 8)].

<p>Organ Related Markers and Functional Test [Mean (SD); (n = 4 or 8)].</p

Representative Images (H&E) of Jejunum Sections at 15.7 Gy PBI in Male Mice at Day 10.

<p>A: Non-irradiated control from day 4; G: PF4; H: PF7; I: PF4 + PF7; J: Amifostine; K: Irradiated control. Pictures are 600 μm x 600 μm.</p

Regression line shows LD50/30 is 15.7 Gy.

<p>Shown is the % Mortality as a function of the partial body irradiation (PBI) dose received. Male C57BL/6J mice (9–10 weeks old; 14 animals per group) were irradiated at a dose range of 14.5–16.5 Gy using a 6MV LINAC photon source (Varian model #EX-21) while the head, forelimbs, and thorax were shielded. Following irradiation the animals were observed for 30 days. Mortality was seen in the range of 7–90% on days 6–8 after PBI. Probit analysis was done and percent mortality was plotted against radiation dose received (R² is 0.947 indicating a very good fit). The Fisher’s exact test for data points indicate there are statistically significant differences (p<0.05) between 14.5 vs. 16.0 Gy, 14.5 vs. 16.5 Gy, 15.0 vs. 16.5 Gy, and 15.5 vs. 16.5 Gy. From these data the LD30/30, LD50/30, and LD70/30 were established at the levels of 15.3 Gy at a 95% CI of 14.912–15.687 Gy, 15.7 Gy at a 95% CI of 15.307–16.082 Gy, and 16.1 Gy at a 95% CI of 15.702–16.477 Gy, respectively. With R-squared, Fisher’s exact test, and 95% CI of LD30/30, LD50/30, and LD70/30, a high correlation is demonstrated between dose and mortality.</p

Villus length and Crypt number Post Gastrointestinal Radiation Injury [Mean (SD); (n = 8)].

<p>Villus length and Crypt number Post Gastrointestinal Radiation Injury [Mean (SD); (n = 8)].</p

Summary of Changes in Blood and Tissue Parameters With and Without Mitigation After PBI Injury.

<p>Summary of Changes in Blood and Tissue Parameters With and Without Mitigation After PBI Injury.</p