Development and evaluation of herbomineral ointment from Bauhinia variegata L. for wound healing effects

The present study has been undertaken to formulate and evaluate the herbomineral ointment containing Bauhinia variegata L. extract. The ointment formulation was designed by using aqueous extract of stem barks of Bauhinia variegata (Linn.), mineral and other excipients needed for formulation. Wound healing activity of herbomineral ointment was evaluated in excision and incision wound models in rats. The ointment was prepared by using B. variegata extract, prawal bhasma, propylene glycol, stearyl alcohol, white petrolatum and required amount of distilled water. The prepared herbomineral ointment was evaluated for physical appearance, pH, spreadability, skin irritation to observe side effects and also for wound healing activity. The herbomineral formulation was found to be good in appearance, homogeneity and it possessed significant (P <0.001) wound healing effect compared to the positive control group and nearly comparable with a standard group. In the incision wound model of rats, the formulation showed a significant increase in the skin breaking strength compared to control and reference standard. The results suggested that herbomineral formulation possessed significant wound healing potential

Development and evaluation of herbomineral ointment from Bauhinia variegata L. for wound healing effects

96-100The present study has been undertaken to formulate and evaluate the herbomineral ointment containing Bauhinia variegata L. extract. The ointment formulation was designed by using aqueous extract of stem barks of Bauhinia variegata (Linn.), mineral and other excipients needed for formulation. Wound healing activity of herbomineral ointment was evaluated in excision and incision wound models in rats. The ointment was prepared by using B. variegata extract, prawal bhasma, propylene glycol, stearyl alcohol, white petrolatum and required amount of distilled water. The prepared herbomineral ointment was evaluated for physical appearance, pH, spreadability, skin irritation to observe side effects and also for wound healing activity. The herbomineral formulation was found to be good in appearance, homogeneity and it possessed significant (P <0.001) wound healing effect compared to the positive control group and nearly comparable with a standard group. In the incision wound model of rats, the formulation showed a significant increase in the skin breaking strength compared to control and reference standard. The results suggested that herbomineral formulation possessed significant wound healing potential

Review on pharmacology activities of Justicia Gendarussa Burm F.

Introduction: Traditional remedies made from medicinal plants have been used for human treatment since ancient times. Justicia gendarussa is a medicinal plant belonging to the Acanthaceae family. Its use in traditional medicine for treating various ailments is supported by its scientifically proven pharmacological actions. The plant exhibits a wide range of pharmacological activities such as antidiabetic, antioxidant, antinociceptive, antimicrobial, anticancer, hepatoprotective, and immunomodulatory activities. Methods: We have collected the data which supported this idea to conduct a comprehensive review by using scientific databases such as Pub Med ®, Science Direct ® and Google Scholar ®. The use of suitable keywords in listed scientific search engine like bioactive molecules of Justicia gendarussa, pharmacological activities of herbal plant, medicinal values of natural herbs etc. An attempt was made to refer to all English-language articles published between1987 and 2023. Result & discussion: Therefore, Justicia gendarussa is a promising medicinal plant with various pharmacological activities, and its phytochemical constituents have demonstrated potential as new drug leads for the treatment of various diseases. However, further studies are needed to fully understand its mechanisms of action, safety, and efficacy before it can be recommended for clinical use. The plant was found to have broad spectrum of activities due to the presence of active constituents like alkaloids, flavonoids, phenolic compounds, steroids, carbohydrate, carotenoids and terpenoids