Application of hypoxia-mesenchymal stem cells in treatment of anaerobic bacterial wound infection: wound healing and infection recovery

Mesenchymal stromal cells, commonly referred to as MSCs, are a type of multipotent stem cells that are typically extracted from adipose tissue and bone marrow. In the field of tissue engineering and regenerative medicine, MSCs and their exosomes have emerged as revolutionary tools. Researchers are now devoting greater attention to MSCs because of their ability to generate skin cells like fibroblasts and keratinocytes, as well as their distinctive potential to decrease inflammation and emit pro-angiogenic molecules at the site of wounds. More recent investigations revealed that MSCs can exert numerous direct and indirect antimicrobial effects that are immunologically mediated. Collectively, these antimicrobial properties can remove bacterial infections when the MSCs are delivered in a therapeutic setting. Regardless of the positive therapeutic potential of MSCs for a multitude of conditions, transplanted MSC cell retention continues to be a major challenge. Since MSCs are typically administered into naturally hypoxic tissues, understanding the impact of hypoxia on the functioning of MSCs is crucial. Hypoxia has been postulated to be among the factors determining the differentiation of MSCs, resulting in the production of inflammatory cytokines throughout the process of tissue regeneration and wound repair. This has opened new horizons in developing MSC-based systems as a potent therapeutic tool in oxygen-deprived regions, including anaerobic wound infection sites. This review sheds light on the role of hypoxia-MSCs in the treatment of anaerobic bacterial wound infection in terms of both their regenerative and antimicrobial activities

The Effect of Socio-Personal Factors on Economic and Managerial Variables in Shahroud Commercial Dairy Farms

The purpose of this research was to study the effects of four personal and social variables including the age, literacy, job experience and size of herd on different variables such as implementing of managerial strategies in transition period, relevant costs of these strategies, average production per head and gross income of milk sale per head. For this purpose all required information were collected through questionnaire distribution among the owners of commercial dairy farms of Shahroud district. This questionnaire was included three parts. Relevant information about personal and social indices was inserted in first part. Second part included of relevant information about performance and non-performance of considered managerial strategies in transition period and third part was about relevant information about production and economic records. Finally all information about 50 herds was obtained and compared as well. Data analysis was through applying Multiple Linear Regression (MLR) method. Also it was possible to specify any relation among independent and dependent variables through calculation of Pearson Correlation Coefficient. Finally it was revealed that social and personal factors have a significant effect on the implementation of management strategies and other independent factors

The Effect of Socio-Personal Factors on Economic and Managerial Variables in Shahroud Commercial Dairy Farms

The purpose of this research was to study the effects of fourpersonal and social variables including the age, literacy,job experience and size of herd on different variables such asimplementing of managerial strategies in transition period,relevant costs of these strategies, average production per headand gross income of milk sale per head. For this purpose allrequired information were collected through questionnairedistribution among the owners of commercial dairy farms ofShahroud district. This questionnaire was included three parts.Relevant information about personal and social indices wasinserted in first part. Second part included of relevant informationabout performance and non-performance of considered managerialstrategies in transition period and third part was aboutrelevant information about production and economic records.Finally all information about 50 herds was obtained andcompared as well. Data analysis was through applying MultipleLinear Regression (MLR) method. Also it was possible tospecify any relation among independent and dependent variablesthrough calculation of Pearson Correlation Coefficient. Finallyit was revealed that social and personal factors have a significanteffect on the implementation of management strategies andother independent factors

Double-edged sword of JAK/STAT signaling pathway in viral infections: novel insights into virotherapy

Abstract The Janus kinase/signal transducer and activator of transcription (JAK/STAT) is an intricate signaling cascade composed of various cytokines, interferons (IFN, growth factors, and other molecules. This pathway provides a delicate mechanism through which extracellular factors adjust gene expression, thereby acting as a substantial basis for environmental signals to influence cell growth and differentiation. The interactions between the JAK/STAT cascade and antiviral IFNs are critical to the host’s immune response against viral microorganisms. Recently, with the emergence of therapeutic classes that target JAKs, the significance of this  cascade has been recognized in an unprecedented way. Despite the functions of the JAK/STAT pathway in adjusting immune responses against viral pathogens, a vast body of evidence proposes the role of this cascade in the replication and pathogenesis of viral pathogens. In this article, we review the structure of the JAK/STAT signaling cascade and its role in immuno-inflammatory responses. We also highlight the paradoxical effects of this pathway in the pathogenesis of viral infections. Video Abstract Graphical Abstrac

Internet Addiction and Sleep Disorders among Medical Students

Background. Considering the increasing use of the Internet in Iranian society, especially among students, and the importance of sleep quality, the present study investigated the relationship between sleep quality and Internet addiction among medical students in Shiraz. Methods. In this descriptive-analytical study, the sample included students of the Shiraz University of Medical Sciences who were selected by a multistage sampling method in 2018. Each faculty was considered to be stratified, and the samples were selected from all strata by simple random sampling. A total of 400 student questionnaires were eligible for analysis. The level of sleep disturbance was measured using the Pittsburgh Sleep Quality Index (PSQI), and Young’s Internet Addiction Test (IAT) was used to evaluate Internet addiction. Cronbach’s alpha for PSQI and IAT was 0.77 and 0.93, respectively. Results. 109 (%28.9) and 58 (%14.4) of all the people under study were at risk of Internet addiction or poor sleep quality, respectively. The highest percentage of poor sleep quality was in those who were addicted to the Internet (60%), but the lowest percentage was observed in the group without addiction (27%). In addition, there was a significant correlation between Internet addiction and subjective sleep quality (r = 0.191, p = 0.05), sleep latency (r = 0.129, p = 0.01), sleep duration (r = 0.119, p = 0.01), habitual sleep efficiency (r = 0.186, p = 0.05), sleep disturbances (r = 0.169, p = 0.01), use of sleeping medication (r = 0.203, p = 0.05), and daytime dysfunction (r = 0.188, p = 0.05). Conclusion. These findings help national health officials and planners in Iran to design appropriate and effective interventions to improve students’ health and prevent Internet addiction