INHIBITOR BIOSENSOR SYSTEMS IN DYNAMIC MODE

The biosensor amperometric transducers can work in the case of three basic types of reversible inhibitor enzyme systems – with competitive inhibition, with non-competitive inhibition and mixed inhibition. Tipicaly they work in static mode. Now they are investigated in dynamic mode. In the paper are investigated the influence of starting concentration of inhibitor over output current of the biosensor with three type inhibition enzyme kinetic in dynamic mode. Those kinetic is generally discussed in terms of a simple extension to the Michaelis-Menten reaction scheme. The biosensor is amperometric product sensitive. Solving system of non-linear partial differential equations is reseived in three dimensional size and the concentration profiles of substrate S(x,t), inhibitor I(x,t) and product P(x,t) are reseived. The models are described in non stationary diffusion conditions. The systems of non-linear differential partial equations are solved numerically in MATLAB medium. In the 3D vision are given reagents concentration changing in the active membrane