325 research outputs found

    External Reserves and Selected Key Macroeconomic Variables in Nigeria: An Empirical Analysis (2000-2018)

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    The paper determines empirically the interactive influence of external reserves and selected key macroeconomic variables in Nigeria using an autoregressive distributive lag (ARDL) model, cointegration and error correction model anticipated by Pesaran, Shin and Smith (2001) with quarterly data between 2000 and 2018 sourced from Central Bank statistics portal on data warehouse pro platform at https://cbnstatistics.datawarehousepro.com. The paper applied the Augmented Dickey-Fuller (ADF) unit root in testing variables stationarity. The Cumulative sum (CUSUM) as well as the Cumulative sum of square (CUSUMSQ) display some recursive outstanding schemes of the external reserve function that remain within the 5% critical positions, and therefore gave an indication of steady external reserve purpose for Nigeria during the study period. The key variables trade openness that captured the total imports and exports by way of proportion of gross domestic product (GDP), exchange rate, direct investment, portfolio investment, oil price, consumer price index, interest rates have correct signs and the ARDL regression analysis indicates that the descriptive variables elucidate and accounted for 99% disparities in external reserves model. The bounds cointegration test exhibited that the variables are cointegrated. The paper demonstrated several empirical supports for the theoretical implications. Precisely, the log of direct investment, portfolio investment, trade openness and interest rate have positive effect, statistically significant and contributes to the external reserves position in Nigeria on the short- run. Jel. Classification Numbers: F21, F32, F34 DOI: 10.7176/JESD/11-10-08 Publication date:May 31st 202

    Exposure to sixty minutes of hyperoxia upregulates myocardial humanins in patients with coronary artery disease - A pilot study

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    In experimental setting the concept of myocardial preconditioning by hyperoxia has been introduced and different intracellular protective mechanisms and their effects have been described. To study whether similar protective phenotype can be induced by hyperoxia also in humans, gene expression profile after hyperoxic exposure was analyzed. Adult patients were randomized to be ventilated with either FiO2 0.4 (n = 14) or 1.0 (n = 10) for 60 minutes before coronary artery bypass grafting. A tissue sample from the right atrial appendage was taken for gene analysis and expression profile analysis on genome wide level by RNA-seq analysis was applied. Exposure to > 96% oxygen for 60 minutes significantly changed the expression of 20 different genes, including upregulation of two different humanins - MTRNR2L2 and MTRNR2L8, and activated a "cell survival" network as detected by Ingenuity Pathway Analyses. We concluded that administration of > 96% oxygen for 1 hour changes gene expression in the myocardium of the patients with coronary artery disease and may enhance cell survival capability

    Continuous Single-Phase Synthesis of [Au₂₅(Cys)₁₈] Nanoclusters and their Photobactericidal Enhancement

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    Thiolate–gold nanoclusters have various applications. However, most of the synthesis methods require prolonged synthesis times from several hours to days. In the present study, we report a rapid synthesis method for [Au25(Cys)18] nanoclusters and their application for photobactericidal enhancement. For [Au25(Cys)18] synthesis, we employed a tube-in-tube membrane reactor using CO as a reducing agent at elevated temperatures. This approach allows continuous generation of high-quality [Au25(Cys)18] within 3 min. Photobactericidal tests against Staphylococcus aureus showed that crystal violet-treated polymer did not have photobactericidal activity, but addition of [Au25(Cys)18] in the treated polymer demonstrated a potent photobactericidal activity at a low white light flux, resulting in >4.29 log reduction in viable bacteria numbers. Steady-state and time-resolved photoluminescence spectroscopies demonstrated that after light irradiation, photoexcited electrons in crystal violet flowed to [Au25(Cys)18] in the silicone, suggesting that redox reaction from [Au25(Cys)18] enhanced the photobactericidal activity. Stability tests revealed that leaching of crystal violet and [Au25(Cys)18] from the treated silicone was negligible and cyclic testing showed that the silicone maintained a strong photobactericidal activity after repeated use

    (0,2) Deformations of Linear Sigma Models

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    We study (0,2) deformations of a (2,2) supersymmetric gauged linear sigma model for a Calabi-Yau hypersurface in a Fano toric variety. In the non-linear sigma model these correspond to some of the holomorphic deformations of the tangent bundle on the hypersurface. Combinatorial formulas are given for the number of these deformations, and we show that these numbers are exchanged by mirror symmetry in a subclass of the models.Comment: 35 pages; uses xy-fig; typos fixed, acknowledgments adde

    Photobactericidal activity activated by thiolated gold nanoclusters at low flux levels of white light

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    The emergence of antibiotic resistant bacteria is a major threat to the practice of modern medicine. Photobactericidal agents have obtained significant attention as promising candidates to kill bacteria, and they have been extensively studied. However, to obtain photobactericidal activity, an intense white light source or UV-activation is usually required. Here we report a photobactericidal polymer containing crystal violet (CV) and thiolated gold nanocluster ([Au25(Cys)18]) activated at a low flux levels of white light. It was shown that the polymer encapsulated with CV do not have photobactericidal activity under white light illumination of an average 312 lux. However, encapsulation of [Au25(Cys)18] and CV into the polymer activates potent photobactericidal activity. The study of the photobactericidal mechanism shows that additional encapsulation of [Au25(Cys)18] into the CV treated polymer promotes redox reactions through generation of alternative electron transfer pathways, while it reduces photochemical reaction type-ІІ pathways resulting in promotion of hydrogen peroxide (H2O2) production

    Comparative assessment of phototherapy protocols for reduction of oxidative stress in partially transected spinal cord slices undergoing secondary degeneration

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    Background: Red/near-infrared light therapy (R/NIR-LT) has been developed as a treatment for a range of conditions, including injury to the central nervous system (CNS). However, clinical trials have reported variable or sub-optimal outcomes, possibly because there are few optimized treatment protocols for the different target tissues. Moreover, the low absolute, and wavelength dependent, transmission of light by tissues overlying the target site make accurate dosing problematic. Results: In order to optimize light therapy treatment parameters, we adapted a mouse spinal cord organotypic culture model to the rat, and characterized myelination and oxidative stress following a partial transection injury. The ex vivo model allows a more accurate assessment of the relative effect of different illumination wavelengths (adjusted for equal quantal intensity) on the target tissue. Using this model, we assessed oxidative stress following treatment with four different wavelengths of light: 450 nm (blue); 510 nm (green); 660 nm (red) or 860 nm (infrared) at three different intensities: 1.93 × 10Âč⁶ (low); 3.85 × 10Âč⁶ (intermediate) and 7.70 × 10Âč⁶ (high) photons/cmÂČ/s. We demonstrate that the most effective of the tested wavelengths to reduce immunoreactivity of the oxidative stress indicator 3-nitrotyrosine (3NT) was 660 nm. 860 nm also provided beneficial effects at all tested intensities, significantly reducing oxidative stress levels relative to control (p ≀ 0.05). Conclusions: Our results indicate that R/NIR-LT is an effective antioxidant therapy, and indicate that effective wavelengths and ranges of intensities of treatment can be adapted for a variety of CNS injuries and conditions, depending upon the transmission properties of the tissue to be treated.12 page(s

    Low-Level Laser Therapy Activates NF-kB via Generation of Reactive Oxygen Species in Mouse Embryonic Fibroblasts

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    Background Despite over forty years of investigation on low-level light therapy (LLLT), the fundamental mechanisms underlying photobiomodulation at a cellular level remain unclear. Methodology/Principal Findings In this study, we isolated murine embryonic fibroblasts (MEF) from transgenic NF-kB luciferase reporter mice and studied their response to 810 nm laser radiation. Significant activation of NF-kB was observed at fluences higher than 0.003 J/cm2 and was confirmed by Western blot analysis. NF-kB was activated earlier (1 hour) by LLLT compared to conventional lipopolysaccharide treatment. We also observed that LLLT induced intracellular reactive oxygen species (ROS) production similar to mitochondrial inhibitors, such as antimycin A, rotenone and paraquat. Furthermore, we observed similar NF-kB activation with these mitochondrial inhibitors. These results, together with inhibition of laser induced NF-kB activation by antioxidants, suggests that ROS play an important role in the laser induced NF-kB signaling pathways. However, LLLT, unlike mitochondrial inhibitors, induced increased cellular ATP levels, which indicates that LLLT also upregulates mitochondrial respiration. Conclusion We conclude that LLLT not only enhances mitochondrial respiration, but also activates the redox-sensitive NFkB signaling via generation of ROS. Expression of anti-apoptosis and pro-survival genes responsive to NFkB could explain many clinical effects of LLLT.National Institutes of Health (U.S.) (grant R01AI050875)Center for Integration of Medicine and Innovative Technology (DAMD17-02-2-0006)United States. Dept. of Defense (CDMRP Program in TBI, W81XWH-09-1-0514)United States. Air Force Office of Scientific Research (FA9950-04-1-0079

    On Îł\gamma-vectors satisfying the Kruskal-Katona inequalities

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    We present examples of flag homology spheres whose γ\gamma-vectors satisfy the Kruskal-Katona inequalities. This includes several families of well-studied simplicial complexes, including Coxeter complexes and the simplicial complexes dual to the associahedron and to the cyclohedron. In these cases, we construct explicit simplicial complexes whose ff-vectors are the γ\gamma-vectors in question. In another direction, we show that if a flag (d−1)(d-1)-sphere has at most 2d+22d+2 vertices its γ\gamma-vector satisfies the Kruskal-Katona inequalities. We conjecture that if Δ\Delta is a flag homology sphere then γ(Δ)\gamma(\Delta) satisfies the Kruskal-Katona inequalities. This conjecture is a significant refinement of Gal's conjecture, which asserts that such γ\gamma-vectors are nonnegative.Comment: 18 pages; Our main result and conjectures have been strengthened. Also we now have explicit constructions of simplicial complexes whose ff-vectors are the γ\gamma-vectors in questio
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