Monitoring of DNA damage in foundry and pottery workers exposed to silica by the alkaline comet assay

Background Workers in foundry and pottery are exposed to a mixture of chemicals and silica, which is suspected to cause genetic alterations. Methods To investigate the potential hazard associated with the occupational exposure to silica, DNA damage in the peripheral lymphocytes of 30 foundry and 22 pottery workers were examined by the alkaline single‐cell gel electrophoresis or Comet Assay, and compared to 52 healthy subjects with no history of occupational silica or chemical exposure. Results The DNA damage observed in the lymphocytes of both foundry and pottery workers was significantly higher than that in their controls. Cigarette smoking was also related to DNA damage since the DNA damage observed in smoking silica‐exposed workers compared with the non‐smoking workers was significantly higher. Conclusions Occupational exposure of silica from foundry and pottery workplaces has been

Assessment of Dna damage in workers occupationally exposed to hazardous chemicals

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Sclerosing Mesenteritis Mimicking Ovarian Tumor: A Very Rare Case

Sclerosing mesenteritis is a rare, benign and chronic inflammatory disease with fibrosis that affects the mesentery and on rare occasions mesocolon, peripancreatic region, omentum, retroperitoneum, pelvis. Since the sclerosing mesenteritis has no special clinical manifestations and typical signs, the patients are very easy to be misdiagnosed. We report a case of sclerosing mesenteritis in 38 year-old patient which is misdiagnosed as ovarian tumor both clinically and radiologically. Definitive diagnosis was made with omental biopsy taken via laparatomy. There was only omental involvement without mesenteric and/or intestinal involvement. This is the first case in the literature with primary omental involvement. The striking point of the case was omental replacement towards pelvis mimicking adnexal mass. Even it is a very rare condition sclerosing mesenteritis should be kept in mind in the differential diagnosis of a pelvic mass

INVESTIGATION OF THE SUPERIORITY OF TDxFML AND LAMELLAR BODY COUNTS IN THE EVALUATION OF FETAL LUNG MATURATION

Objective: To evaluate the superiority of the most performed tests; lamellar body counts and TDxFLM test compared to each other to estimate the maturation of fetal lungs and also to evaluate the reasons for the unclear cut-off values of lamellar body counts. Material and Method: Amnion fluids that were taken into 2 separate tubes from 56 patients within a year were evaluated with both of the tests. Newborns were evaluated and monitored for respiratory distress syndrome of newborns by a neonatologist who was blinded to the results of the amnion fluids. Clinical findings such as grunting, tachypnea, retractions and cyanosis beginning within 6-8 hours after birth, oxygen need over 24 hours, arterial blood gas analyses with partial oxygen pressure under 50 mmHg and presence of chest x-ray findings that are compatible with the situation were accepted as the respiratory distress of newborns. Results: Respiratory distress was not seen in 44 of the 56 newborns while it was seen in 12 (21.4%) of them. In 30 patients whose lamellar body counts were > 55000/mm(3) without centrifuge, RDS was not seen. In the patients whose lamellar body counts were 41, all cases can be detected. Conclusion: Count of lamellar bodies is adiagnostic tool which is fast, practical, easily accessible and cost-effective; also there is no doubt on the benefits of the tool. It seems that the different cut-off values have reasonable causes. Thus, we suggest that every clinic should have its own cut-off values. In the presence of interim results, additional evaluation with TDxFLM was found to increase the sensitivity and specificity.WOS:00040990730000