Overview of descriptive data for patients with Parkinson’s disease (PD) and the control group (CG).

<p>f: female, m: male; TEDD: Test for Early Detection of Dementia; QADP: Questionnaire for the Assessment of Disgust Proneness; BDI: Beck Depression Inventory; STAI: State Trait Anxiety Inventory (trait scale); STAXI: State Trait Anger Inventory (trait scale).</p><p>Overview of descriptive data for patients with Parkinson’s disease (PD) and the control group (CG).</p

Regions with increased activation in patients compared to controls.

<p>Regions with increased activation in patients compared to controls.</p

Comparison of brain activation in the emotion conditions between patients with Parkinson’s disease (PD) and the control group (CG).

<p>BA = Brodmann Area; H = hemisphere, MNI coordinates (x,y,z), <i>p</i>(FWE) = corrected for family-wise error, CS = cluster size (number of voxels).</p><p>Comparison of brain activation in the emotion conditions between patients with Parkinson’s disease (PD) and the control group (CG).</p

Regional magnetic susceptibility and R2* values.

<p>Regional magnetic susceptibility and R2* values.</p

Univariate correlations of R2* and magnetic susceptibility for patients with shorter and longer disease duration dichotomized by median disease duration (3.4 years).

<p>Univariate correlations of R2* and magnetic susceptibility for patients with shorter and longer disease duration dichotomized by median disease duration (3.4 years).</p

Univariate correlations of R2* and magnetic susceptibility with clinical parameters for patients with PD.

<p>Univariate correlations of R2* and magnetic susceptibility with clinical parameters for patients with PD.</p

Regional mean susceptibilities and R2* (±standard deviation).

<p>Asterisks denote significant differences between controls and patients with Parkinson’s disease (*p<0.05; **p<0.01; ***p< = 0.001).</p

Clinical and demographic data of the study cohort.

<p>Clinical and demographic data of the study cohort.</p

Representative T1-weighted MP-RAGE image (left) with color overlay of segmented deep gray matter structures, R2* relaxation rate constant map (center) and quantitative susceptibility map (right) of a 62-years patient with PD (MDS-UPDRS 46; Hoehn & Yahr 2).

<p>High R2* rates and paramagnetic susceptibilities are found in the basal ganglia. Note the improved gray-white matter contrast on the QSM map compared to the R2* map.</p

Morphological data.

<p>Morphological data.</p