GWS SNPs associated with Behçet’s disease susceptibility using GPC and EMMAX approaches.

<p>Results for the association analysis when correcting for 20 PCs to adjust for stratification. In italic font the SNPs which show association only by one of the two approaches.</p><p>* Odd ratios cannot be calculated by EMMAX approach.</p><p>GWS SNPs associated with Behçet’s disease susceptibility using GPC and EMMAX approaches.</p

Genetic substructure of the Combined GWAS dataset.

<p>Two-dimensional scatterplots from multidimensional scaling analyses of the Generation R Study and Behçet collected data together with the three initial Panels form the HapMap Project. Each dot represents an individual in the dataset. Color codes: Grey = Generation R, Black = Behcet Cases, Yellow = Jordan controls. Blue = CEU, Red = YRB, Green = JPT.</p

Behcet GWAS results using Linear Mixed Models Genomic approach.

<p>Each dot represents an SNP in the dataset. QQ-plot (left). Associated SNPs deviating from the null hypothesis of no association (identity line). Manhattan plot (right). SNPs showing association with the disease map to two different signals in chromosome 6 and a singleton in chromosome 18.</p

SNP association plot for Behçet’s susceptibility-associated region of chromosome 6q25.3.

<p>Dots represent GWAS P-values (EMMAX approach) and positions of SNPs found within the 6q25.3 locus. The top SNP, i.e. rs8187722, is denoted by a diamond. Different colours indicate varying degrees of pair-wise linkage disequilibrium (1000 Genomes Nov 2010 CEU) between the top SNP and all other genotyped SNPs. Genetic coordinates are per 1000 Genomes Nov 2010-CEU. Bottom, LD heat map based on D’ values from the combined population under study including all SNPs in the 500Kb region.</p

Meta-analysis of leading SNP in IL12A.

<p>Association results for rs17810456 (G-allele) in two Turkish cohorts (14) and the current study.</p><p>* From <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0119085#pone.0119085.t001" target="_blank">Table 1</a> Kirino et al. 2013</p><p>Meta-analysis of leading SNP in IL12A.</p

SNP association plot for Behçet’s susceptibility-associated region of Chromosome 18q22.3.

<p>Dots represent GWAS P-values (EMMAX approach) and positions of SNPs found within the 18q22.3 locus. The top SNP, i.e. rs17087141, is denoted by a diamond. Different colours indicate varying degrees of pair-wise linkage disequilibrium (1000Genomes CEU) between the top SNP and all other genotyped SNPs. Genetic coordinates are per 1000 Genomes Nov 2010-CEU. Bottom, LD heat map based on D’ values from the combined population under study including all SNPs in the 500Kb region.</p

Behçet GWAS results using Genomic Principal Components (GPC) adjustment.

<p>Each dot represents an SNP in the dataset. QQ-plot (left). Associated SNPs deviating from the null hypothesis of no association (identity line). Manhattan plot (right). SNPs showing association with the disease map to chromosome 6 and a singleton in chromosome 18.</p

Association plots for TB-BMD.

<p>A. SNP association plot for TB-BMD-associated region of Chromosome 7q31.31. B. SNP association plot for TB-BMD-associated region of Chromosome 7q31.31 after conditioning on rs3801382. Genetic coordinates are as per Hapmap phase II-CEU. *Data from the mothers of Generation R is not included.</p

Genome-wide association of TB-BMD in the discovery cohort.

<p>A. Q-Q plot showing the inflation of the test statistics when correction for data structure is not applied (green dots) and the loss of power when no weight correction is applied (red dots) in comparison with the applied model (black dots) and B. Manhattan Plot of the genome wide association analysis of TB-BMD in the Generation R (discovery) cohort of model correcting by age, gender and body weight.</p

Summary statistics for densitometric properties of control (+/+) and <i>Wnt16</i> deficient (−/−) mice.

<p>Results provided as [mean +/− SEM].</p