Ball State University : Golden Key National Honor Society's Best of America Drug Awareness Program, 1991-1993 : an honors thesis (HONRS 499)

This discussion of the Best of America--Say No To Drugs Program shows the efforts of an individual to develop a successful drug awareness program from its utter beginnings. Throughout the description of two subsequent programs, there are the focuses on the program creation on both the National and college levels, the ideals of the programs, and the concept of volunteerism. The discussion allows for the reader to become aware of the failures and successes in the arranging of a drug awareness or a similar program. Hopefully, this thesis may benefit the reader with his or her experience in the creation or planning of an awareness type program.Honors CollegeThesis (B.?.

Functional and Structural Overview of G-Protein-Coupled Receptors Comprehensively Obtained from Genome Sequences

An understanding of the functional mechanisms of G-protein-coupled receptors (GPCRs) is very important for GPCR-related drug design. We have developed an integrated GPCR database (SEVENS http://sevens.cbrc.jp/) that includes 64,090 reliable GPCR genes comprehensively identified from 56 eukaryote genome sequences, and overviewed the sequences and structure spaces of the GPCRs. In vertebrates, the number of receptors for biological amines, peptides, etc. is conserved in most species, whereas the number of chemosensory receptors for odorant, pheromone, etc. significantly differs among species. The latter receptors tend to be single exon type or a few exon type and show a high ratio in the numbers of GPCRs, whereas some families, such as Class B and Class C receptors, have long lengths due to the presence of many exons. Statistical analyses of amino acid residues reveal that most of the conserved residues in Class A GPCRs are found in the cytoplasmic half regions of transmembrane (TM) helices, while residues characteristic to each subfamily found on the extracellular half regions. The 69 of Protein Data Bank (PDB) entries of complete or fragmentary structures could be mapped on the TM/loop regions of Class A GPCRs covering 14 subfamilies