Removal of reactive dyes using a high throughput-hybrid separation process

Toxic and carcinogenic reactive dyes are abundantly used in textile industries due to their wide variety of colour and texture. In this study, a hybrid separation process was used to remove four common reactive dyes (reactive yellow, red, black and brown) from aqueous solution. Synthetic solution of these dyes was subjected to adsorption by activated carbon followed by microfiltration (MF), using a ceramic membrane module. Dyes were completely removed by adsorption at pH 4.5 and the dye-loaded adsorbents were removed by cross-flow MF. Maximum Langmuir adsorption capacity of activated carbon for these four dyes was in the range of 88-106mg/g. Effects of trans-membrane pressure drop and cross-flow rate on the throughput of the combined process was investigated. Membrane fouling was due to the cake type of layer formed by the activated carbon particles. Five different washing protocols were tested for their efficiency and the acid-alkali wash was found to be the most effective

Synthesis and Evaluation of Technetium-99m-Labeled Bioreductive Pharmacophores Conjugated with Amino Acids and Peptides for Tumor Imaging

Development of molecular imaging agents to target tumor has become a major trend in nuclear medicine. With the aim to develop new potential 99mTc-radiopharmaceuticals for targeting tumor, we have synthesized 5-nitroimidazolyl amino acids and RGD-coupled 2-nitroimidazoles. Technetium-99m radiolabeling with high radiochemical purity (>90%) was achieved for all the compounds. The radiolabeled complexes exhibited substantial in vitro stability in saline, serum, and histidine solution (10�2M). Cell binding studies in EAC and B16F10 cell lines also revealed rapid and comparatively high cellular internalization. Among all the compounds studied, the binding of 99mTc(CO)3-5 to B16F10 cells was moderately inhibited by the competitive peptide c[RGDfV], suggesting specificity of the radioligand toward avb3 receptor. However, no significant displacement of bound radioligand was observed when the binding of the 99mTc-labeled complexes to above cells was challenged with excess competitive peptide. Fluorescent microscopy study provided direct evidence of intracellular localization of 5(6)-carboxyfluorescein- labeled 2-nitroimidazolyl-RGD-peptide in avb3-positive B16F10 mouse melanoma cell line. The ligands caused only 8–13% of hemolysis toward rat erythrocytes at concentrations as high as 100 lM. Imaging and biodistribution studies were performed in Swiss albino mice bearing induced tumor. 99mTc-1 and 99mTc(CO)3-5 demonstrated a very favorable in vivo profile. Selective uptake and retention in tumor with encouraging tumor/muscle and tumor/blood ratio and significant cellular uptake of fluorescence-labeled-2-nitroimidazolyl RGD indicate the great potentiality of the pharmacophore for further evaluation as potential molecular imaging agent in cancer diagnosis

Abstracts of 1st International Conference on Machine Intelligence and System Sciences

This book contains the abstracts of the papers presented at the International Conference on Machine Intelligence and System Sciences (MISS-2021) Organized by the Techno College of Engineering, Agartala, Tripura, India & Tongmyong University, Busan, South Korea, held on 1–2 November 2021. This conference was intended to enable researchers to build connections between different digital technologies based on Machine Intelligence, Image Processing, and the Internet of Things (IoT). Conference Title: 1st International Conference on Machine Intelligence and System SciencesConference Acronym: MISS-2021Conference Date: 1–2 November 2021Conference Location: Techno College of Engineering Agartala, Tripura(w), IndiaConference Organizer: Techno College of Engineering, Agartala, Tripura, India & Tongmyong University, Busan, South Korea