1 research outputs found
Impact of Wheat Aleurone Structure on Metabolic Disorders Caused by a High-Fat Diet in Mice
The
present study investigated the potential of native and structurally
modified wheat aleurone, by dry-grinding or enzymatic treatments,
to counteract metabolic disorders in mice with diet-induced obesity
(DIO). C57BL6/J mice were first fed ad libitum with a high-fat diet
for 9 weeks to induce obesity, after which the native or treated aleurone
fractions were added (13% (w/w)) in the high-fat diets for an additional
8 weeks. The effects of the aleurone-enriched diets were evaluated
by assessing body weight gain, adiposity, fasting blood glucose, plasma
insulin and leptin, and anti-inflammatory and oxidative stress markers.
Enrichment of the diet with native or finely ground aleurone did not
improve any parameter analyzed; finely ground aleurone even slightly
increased (<i>p</i> = 0.03) body weight gain. Enrichment
of the diet with enzymatically treated aleurone only had a tendency
toward lower body weight gain, visceral adipose tissue accumulation,
fasting plasma insulin, and leptin levels