LocusZoom plot of chronotype associations in the <i>PER2</i> locus.

<p>Variants are coloured by their LD r² with lead variant rs75804782 and those with association <i>P</i>-values > 0.01 were omitted for clarity.</p

Genetic variants associated with chronotype (as either a continuous or binary trait) at <i>P</i><5x10^-8 in the UK Biobank study.

<p>Variants highlighted in bold were not identified by the 23andMe study, those in italic did not reach genome-wide significance on meta-analysis and those not highlighted replicate previously reported loci from 23andMe. Genes listed are candidate or nearest genes within 250Kb of the lead SNP. Odds ratios correspond to risk of morningness over eveningness. Beta, OR and frequency refers to A1. Replication data is based on continuous data and as the replication beta is in different units to the discovery GWAS beta, a P-value meta-analysis was performed.</p

LocusZoom plots of sleep duration associations in the <i>VRK2</i> locus.

<p>Both plots show the same locus but each highlights a different lead variant: rs1380703 (left) and rs17190618 (right). Variants with association <i>P</i>-values > 0.01 were omitted for clarity. The two leads variants represent separate signals.</p

LocusZoom plot of chronotype associations in the <i>RGS16</i> locus.

<p>The plot displays -log₁₀ <i>P</i>-value on the y-axis and physical position on the x-axis. Points identify individual variants whose colour indicates their LD r² with lead variant rs516134. The blue line indicates pre-calculated recombination rates (in cM/Mb) at each position. Variants with association <i>P</i>-values > 0.01 were omitted for clarity.</p

Manhattan and quantile-quantile (QQ) plots for chronotype.

<p>Summary information plots for inverse-normalised (self-report) Sleep Duration vs. ~16.8 million imputed genetic variants in 127,573 White British individuals in the UK Biobank study. The Manhattan plot (top) shows association test (-log₁₀ <i>P</i>-value on the y-axis against physical autosomal location on the x-axis with the standard genome-wide significance cutoff of <i>P</i> = 5x10^-8 shown by the horizontal black line. Variants tested had imputation R²>0.4, a Hardy-Weinberg Equilibrium (HWE) <i>P</i>-value > 1x10^-6 and minor allele frequency (MAF) > 0.1%. The Sleep Duration QQ plot (bottom) identifies some inflation (λ_GC = 1.097) but, as with Chronotype, this is consistent with expected inflation from a highly polygenic trait in such a large sample size [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1006125#pgen.1006125.ref015" target="_blank">15</a>].</p