The influence of blood on the efficacy of intraperitoneally applied phospholipids for prevention of adhesions

<p>Abstract</p> <p>Background</p> <p>The formation of adhesions following abdominal surgery is a well known problem. In previous studies we demonstrated the efficacy and safety of intraperitoneally applied phospholipids in order to prevent adhesion formation. This study evaluates the influence of blood on the efficacy of intraperitoneally applied phospholipids for prevention of adhesions.</p> <p>Methods</p> <p>In 40 Chinchilla rabbits adhesions were induced by median laparotomy, standardized abrasion of the visceral and parietal peritoneum in defined areas of the ventral abdominal wall and the caecum. The animals were randomly divided into four groups. They received either phospholipids 3.0% or normal saline (NaCl 0,9%) (5 ml/kg body weight). In 50% of the rabbits we simulated intraperitoneal bleeding by administration of blood (1,5 ml/kg body weight). The other half served as control group. Ten days following the operation the animals were sacrificed and adhesion formation was assessed by computer aided planimetry and histopathologic examination.</p> <p>Results</p> <p>The median adhesion surface area in the NaCl-group (n = 9) amounted to 68,72 mm², in the NaCl+Blood-group (n = 10) 147,68 mm². In the Phospholipid (PhL)-group (n = 9) the median adhesion surface area measured 9,35 mm², in the PhL+Blood-group (n = 9) 11,95 mm². The phospholipid groups had a significantly smaller adhesion surface area (p < 0.05).</p> <p>Conclusion</p> <p>Again these results confirm the efficacy of phospholipids in the prevention of adhesions in comparison to NaCl (p = 0,04). We also demonstrated the adhesion preventing effect of phospholipids in the presence of intraperitoneal blood.</p

Development of a generalized technique for the algebraic formation of B-functions for three points

Розглядається застосування математичного апарату точкового числення Балюби-Найдиша для моделювання багатофакторних процесів. Зокрема, розглядається метод побудови параболічних поверхонь відгуку на основі Б-функцій (Балюби функцій) в точковому численні. Авторами взята за основу геометрична схема побудови параболи другого ступеня у точковій формі. Дослідження властивостей функцій-параметрів на прикладах побудови кривої по трьох точках показали, що з метою створення моделей багатофакторних процесів, Б-функції можна отримувати і алгебраїчним шляхом. Розроблено узагальнену техніку алгебраїчного формування Б-функцій з метою визначення класу кривих, що визначаються множиною Б-функцій, які являють собою новий клас функцій.The problem of multifactor processes modeling, in particular, in the sphere of application of energy-saving technologies is acute at the moment. Many approaches have been developed, each of which has advantages and disadvantages. For example, the existing methods of geometric modeling allow solving many problems in the sphere of support for making managerial decisions. However, as often happens in practice, the complexity of the application of these analytical methods increases in an avalanche-like manner with an increase in the number of input factors of the model. In our opinion, in order to solve this problem, the mathematical apparatus of the Balyuba-Naidysh point calculus is optimal as a tool