Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals

We conduct a genome-wide association study (GWAS) of educational attainment (EA) in a sample of ~3 million individuals and identify 3,952 approximately uncorrelated genome-wide-significant single-nucleotide polymorphisms (SNPs). A genome-wide polygenic predictor, or polygenic index (PGI), explains 12-16% of EA variance and contributes to risk prediction for ten diseases. Direct effects (i.e., controlling for parental PGIs) explain roughly half the PGI's magnitude of association with EA and other phenotypes. The correlation between mate-pair PGIs is far too large to be consistent with phenotypic assortment alone, implying additional assortment on PGI-associated factors. In an additional GWAS of dominance deviations from the additive model, we identify no genome-wide-significant SNPs, and a separate X-chromosome additive GWAS identifies 57

Legislative Documents

Also, variously referred to as: House bills; House documents; House legislative documents; legislative documents; General Court documents

Additional file 10: of Enrichment of B cell receptor signaling and epidermal growth factor receptor pathways in monoclonal gammopathy of undetermined significance: a genome-wide genetic interaction study

Summary of Illumina bead chips used for genotyping different batches of cases and controls. (DOCX 19 kb

Additional file 1: of Enrichment of B cell receptor signaling and epidermal growth factor receptor pathways in monoclonal gammopathy of undetermined significance: a genome-wide genetic interaction study

Top interactions from W-Z discovery set interaction test compared with simple logistic linear interaction test (brute force epistasis).ย�Description: SNP1 and SNP2 are the two SNP candidates of a pair from the discovery population belonging to chromosomes denote by Chr1 and Chr2; gene1 and gene2 are the corresponding genes annotated to SNP1 and SNP2, respectively. W-Z P value is Wellek Ziegler test p-value. (DOCX 22 kb

Additional file 6: of Enrichment of B cell receptor signaling and epidermal growth factor receptor pathways in monoclonal gammopathy of undetermined significance: a genome-wide genetic interaction study

PASCAL gene set enrichment analysis results at 1% level of significance. (DOCX 20 kb

Additional file 7: of Enrichment of B cell receptor signaling and epidermal growth factor receptor pathways in monoclonal gammopathy of undetermined significance: a genome-wide genetic interaction study

MAGENTA gene set enrichment analysis results at 1% level of significance. (DOCX 20 kb

Additional file 4: of Enrichment of B cell receptor signaling and epidermal growth factor receptor pathways in monoclonal gammopathy of undetermined significance: a genome-wide genetic interaction study

Overlapped interactions from INTERSNP and CASSI W-Z interaction tests on discovery set. Description: SNP1 and SNP2 are the two SNP candidates of a pair from the discovery set population belonging to chromosomes denote by Chr1 and Chr2; gene1 and gene2 are the corresponding genes annotated to SNP1(s) and SNP2(s), respectively. W-Z P value is Wellek Ziegler case-control test p-value from CASSI and INTERSNP P value is full log-linear test p-value from INTERSNP; BP is base pair. IN: INTERSNP; CAS: CASSI. (DOCX 22 kb