Автоматический выпуск конструкторской документации в PDM-системе

BaFe12O19 powders were prepared by coprecipitation and by glass crystallization. Electron microscopic investigations revealed that the particles of the glass crystallized powder exhibit excellent uniform shapes and narrow size distribution in comparison to the coprecipitated one consisting of irregularly shaped, polycrystalline particles with a broad and inhomogeneous size distribution. The crystallites of the coprecipitated powder particles, however, are smaller (mean diameter D = 0.11 μm) and the size distribution is narrower than that of the particles of the glass crystallized powder with a mean diameter of D = 0.42 μm. The lattice perfection of the particles and the crystallites of both ensembles is quite good. In order to determine the magnetic properties - above all the effective anisotropy field - we used six different methods: transverse susceptibility χt, singular point detection (SPD), ferromagnetic resonance (FMR), torsion pendulum (TP), rotational hysteresis losses (RHL), remanence curves (RC). It has been found that differences in coercivity values HcJ are not dramatic (about ±3%). Effective anisotropy fields Ha measured with “switching” methods (RHL, RC) are smaller than those measured with “stiffness” ones (FMR, TP, SPD, χt), by about 1700 Oe for the coprecipitated powder and about 2500 Oe for the glass crystallized one. The glass crystallized particle assemblies used for the present investigations do not exhibit pure Stoner-Wohlfarth behaviour, because of their relatively large particle diameters. The ratio HcJ/Ha ≈ 0.39 of the coprecipitated powder is relatively near the ideal value of 0.48, although the particles are considerably mechanically aggregated. © 1992

Denen Durchlauchtigsten Fürsten und Herren, Herrn Karl August, und Herrn Friedrich Ferdinand Konstantin, Herzogen zu Sachsen, Jülich, Cleve, Berg, ... ihren ... Fürsten und Herren, suchten bey Dero ... Geburtstagsfeiern welche den 3ten und 8ten September 1770 ... eintraten ihre unterthänigste Schuldigkeit an den Tag zu legen die Gymnasiasten der ersten Ordnung des hochfürstl. Gymnasiums

DENEN DURCHLAUCHTIGSTEN FÜRSTEN UND HERREN, HERRN KARL AUGUST, UND HERRN FRIEDRICH FERDINAND KONSTANTIN, HERZOGEN ZU SACHSEN, JÜLICH, CLEVE, BERG, ... IHREN ... FÜRSTEN UND HERREN, SUCHTEN BEY DERO ... GEBURTSTAGSFEIERN WELCHE DEN 3TEN UND 8TEN SEPTEMBER 1770 ... EINTRATEN IHRE UNTERTHÄNIGSTE SCHULDIGKEIT AN DEN TAG ZU LEGEN DIE GYMNASIASTEN DER ERSTEN ORDNUNG DES HOCHFÜRSTL. GYMNASIUMS Denen Durchlauchtigsten Fürsten und Herren, Herrn Karl August, und Herrn Friedrich Ferdinand Konstantin, Herzogen zu Sachsen, Jülich, Cleve, Berg, ... ihren ... Fürsten und Herren, suchten bey Dero ... Geburtstagsfeiern welche den 3ten und 8ten September 1770 ... eintraten ihre unterthänigste Schuldigkeit an den Tag zu legen die Gymnasiasten der ersten Ordnung des hochfürstl. Gymnasiums ([1]

Association of Plane of Total Mesorectal Excision With Prognosis of Rectal Cancer

IMPORTANCE Previous retrospective studies have shown that surgical quality affects local control in rectal cancer.. OBJECTIVE In this secondary end point analysis, we evaluated the prognostic effect of the total mesorectal excision (TME) plane in the CAO/ARO/AIO-04 phase 3 randomized clinical trial. DESIGN, SETTING, AND PARTICIPANTS The CAO/ARO/AIO-04 trial enrolled 1236 patients with cT3-4 and/or node-positive rectal adenocarcinoma from 88 centers in Germany between July 25, 2006, and February 26, 2010. INTERVENTIONS Patients were randomized to receive treatment with standard fluorouracil-based preoperative chemoradiotherapy (CRT) alone (control arm) or oxaliplatin (experimental arm) followed by TME and adjuvant chemotherapy. MAIN OUTCOMES AND MEASURES The TME quality (mesorectal, intramesorectal, and muscularis propria plane) was prospectively assessed in 1152 operation specimens. An assessment was performed independently by pathologists and surgeons. The results were correlated with clinicopathologic data and the clinical outcome was tested, including multivariable analysis with the Cox regression model. RESULTS Of 1152 German Caucasian participants, 332 (28.8) were women and the mean age was 63 years. The plane of TME was mesorectal in 930 patients(80.7%), intramesorectal in 169(14.7%), and muscularis propriain 53(4.6%). In a univariable analysis, the TME plane was significantly associated with 3-year disease-free survival (mesorectal vs intramesorectal vs muscularis propria, 95% CI, 73.1-78.8 vs 61.6-76.0vs 55.6-81.3, respectively; P=.01), cumulative incidence of local and distant recurrences (mesorectal vs intramesorectal vs muscularis propria, 95% CI, 2.0-4.5 vs 1.2-8.1 vs 2.5-20.5, respectively; P<.001; and mesorectal vs intramesorectal vs muscularis propria, 95% CI, 17.0-22.4 vs 18.3-32.0vs 14.2-39.0, respectively; P=.03, respectively), and overall survival (mesorectal vs intramesorectal vs muscularis propria, 95% CI, 88.3-92.3 vs 79.7-91.0vs 81.6-98.7, respectively; P=.02). In contrast to the pathologist-based evaluation, the assessment of TME plane by the operating surgeon failed to demonstrate prognostic significance for any of these clinical end points. In a multivariable analysis, the plane of surgery (mesorectal vs muscularis propria TME) constituted an independent factor for local recurrence (P=.002). CONCLUSIONS AND RELEVANCE This phase 3 randomized clinical trial confirms the long-term clinical effect of TME plane quality on local recurrence, as initially reported in the MRC CR07 study. The data highlight the key role of pathologists and surgeons in the multidisciplinary management of rectal cancer