Tetramic Acid Analogues Produced by Coculture of <i>Saccharopolyspora erythraea </i>with<i> Fusarium pallidoroseum</i>

Coculture of the fungus <i>Fusarium pallidoroseum</i> with the bacterium <i>Saccharopolyspora erythraea</i> was found to produce three new decalin-type tetramic acid analogues related to equisetin. The structures were determined by spectroscopic methods. The absolute configurations were established by circular dichroism spectroscopy and comparing the data with those of equisetin

Lithothamnin A, the first bastadin-like metabolite from the red alga Lithothamnion fragilissimum.

Lithothamnin A (1) is a new bastadin-like metabolite and represents the first report of this class of molecules from the red alga Lithothamnion fragilissimum. Lithothamnin A contains several novel structural features that distinguish it from other bastadins. These unique structural features include novel aromatic substitution patterns and the presence of a meta-meta linkage between aromatic rings, in addition to the meta-para linkage seen in the bastadins. Lithothamnin A is modestly cytotoxic in a panel of six human tumor cell lines