და-ძმა რუაძეები

ფოტო გადაღებულია საქართვველოს სსრ მხატვრული თვითმოქმედების ინდივიდუალურ შემსრულებელთა რესპუბლიკურ კონკურსზე, რომელიც ჩატარდა 1962 წლის 2 და 3 დეკემბერს თბილისის კავშირგაბმულობის მუშაკთა კულტურის სახლში. სიმღერა "გუდამაყრული", ასრულებენ გურჯაანელი და-ძმა რუაძეები

Additional file 5: of Coagulative safety of epidural catheters after major upper gastrointestinal surgery: advanced and routine coagulation analysis in 38 patients

Raw data with explanation of field codes in first lines. (TXT 18 kb

Boxplots of the four aPTT methods’ results for enoxaparin and tinzaparin in three different concentrations.

<p>When comparing the contiguous groups with the same aPTT-method but different concentrations of LMWH, a significant difference in aPTT was found in all cases. Statistical significances between classes are shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0116835#pone.0116835.s001" target="_blank">S1 File</a>.</p

Molecular weight and anti-factor Xa and anti-factor IIa activities of heparin and commonly used low molecular weight heparins (LMWH).^a

<p>^aThe shorter the LMWH fragments, the more specific the agent is for factor Xa [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0116835#pone.0116835.ref011" target="_blank">11</a>].</p><p>Molecular weight and anti-factor Xa and anti-factor IIa activities of heparin and commonly used low molecular weight heparins (LMWH).<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0116835#t001fn001" target="_blank">^a</a></p

Explanatory to Fig. 4: Correlation and regression between aPTT and Anti-FXa for enoxaparin and tinzaparin.

<p>FOR: free-oscillation rheometry.</p><p>Explanatory to <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0116835#pone.0116835.g004" target="_blank">Fig. 4</a>: Correlation and regression between aPTT and Anti-FXa for enoxaparin and tinzaparin.</p

Relationship between anti-FXa activity and thrombin generation.

<p>Anti-FXa activity is strongly negatively correlated to the logarithm of ETP (Endogenous Thrombin Potential): R_s for enoxaparin and tinzaparin are −0.93 and −0.94 respectively. Anti-FXa activity is more prolonged by enoxaparin than tinzaparin at any given level of thrombin generation.</p

Relationship between aPTT measured using various reagents, and the logarithm of thrombin generation.

<p>See <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0116835#pone.0116835.t003" target="_blank">Table 3</a> for correlation factors and regression lines. There is a negative linear relationship between aPTT and log₁₀(ETP). Tinzaparin results in prolonged aPTT results compared to enoxaparin in the whole blood analyses (FOR and Hemochron Jr) at any given level of thrombin generation.</p

Relationship between measured anti-FXa and the concentration of low molecular weight heparin (LMWH).

<p>There is a strong linear correlation between anti-FXa results and the concentration of LMWH (dosed in anti-FXa units per ml). For enoxaparin and tinzaparin the correlation coefficients R_s are 0.97 and 0.96 respectively.</p

A comparison of enoxaparin and tinzaparin’s relative effects on aPTT.

<p>Bland-Altman plot showing that the aPTT’s induced by tinzaparin ranged from on average 49% more than enoxaparin (when measured using the PTT-Automat reagent) to 66% more than enoxaparin (when measured using the MRX931 reagent (FOR: free oscillation rheometry).</p

Explanatory to Fig. 6.

<p>FOR: free-oscillation rheometry.</p><p>Explanatory to <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0116835#pone.0116835.g006" target="_blank">Fig. 6</a>.</p