Minor allele frequency (MAF) and odds ratio (OR) of <i>MC1R</i> variants in melanoma cases/families compared to the Danish population.

<p>Minor allele frequency (MAF) and odds ratio (OR) of <i>MC1R</i> variants in melanoma cases/families compared to the Danish population.</p

Characteristics of the 13 individuals/families with identified <i>CDKN2A</i> mutations.

<p>SCC: squamous cell carcinoma</p><p>CLL: chronic lymphocytic leukemia</p><p>RCC: renal cell carcinoma</p><p>Characteristics of the 13 individuals/families with identified <i>CDKN2A</i> mutations.</p

Flow-chart of melanoma cases included in the study.

<p>Flow-chart of melanoma cases included in the study.</p

Age at first melanoma in <i>CDKN2A</i> mutation carriers compared to age of first melanoma in individuals with melanoma and no <i>CDKN2A</i> mutation.

<p>Families with a <i>BAP1</i> mutation are not included, nor are individuals with UM.</p><p>Age at first melanoma in <i>CDKN2A</i> mutation carriers compared to age of first melanoma in individuals with melanoma and no <i>CDKN2A</i> mutation.</p

Minor allele frequency (MAF) and odds ratio (OR) of <i>MC1R</i> variants in melanoma cases/families compared to the Danish population.

<p>Minor allele frequency (MAF) and odds ratio (OR) of <i>MC1R</i> variants in melanoma cases/families compared to the Danish population.</p

<i>BAP1</i> analysed in individuals and families with CM and/or UM and mesothelioma.

<p><i>BAP1</i> analysed in individuals and families with CM and/or UM and mesothelioma.</p

MAF and OR of <i>MITF</i> p.E318K in this study compared to the Danish population, and compared to other cohorts of CM patients.

<p>MAF and OR of <i>MITF</i> p.E318K in this study compared to the Danish population, and compared to other cohorts of CM patients.</p

Age-specific penetrance curves for CM in Danish <i>CDKN2A</i> mutation carriers.

<p>Age-specific penetrance curves for CM in Danish <i>CDKN2A</i> mutation carriers.</p

Hazard ratios for CM in <i>CDKN2A</i> carriers according to <i>MC1R</i> genotype, compared to all <i>CDKN2A</i> carriers.

<p>Using Cox regression</p><p>Hazard ratios for CM in <i>CDKN2A</i> carriers according to <i>MC1R</i> genotype, compared to all <i>CDKN2A</i> carriers.</p