Gaming simulation technology in the development of professional- creative competence of students learning english

© 2016 by iSER, International Society of Educational Research. The aim of this article is to develop educational gaming simulation technology contributing to the achievement and development of students’ creative competence as the indicator of their successful self-realization in the profession. The structure of the presented technology includes objective, methodological, content, organizational and technological and result components. The introduction of gaming simulation as an educational technology in the process of the English language training aimed at developing creative educational space which defines the professional-creative competence development of the students - future specialists of foreign language and culture

Features of laboratory indices in workers of chemical production with occupational skin diseases

Changes of haematological and biochemical indices depending on the nosological entities of occupational diseases and the gender were analyzed in workers of chemical complex. Changes of these indices depending on the gender identity were revealed in workers with skin hyperkeratinization at the conduction of medical examination. Eosinophilia, lymphocytosis and leukopenia were revelaed in men with hyperkeratinization, increase of hemoglobin quantity and leukopenia were revealed in women with hyperkeratinization. There were no differences depending on the gender in patients with skin cancer

THPP target assignment reveals EchA6 as an essential fatty acid shuttle in mycobacteria

Phenotypic screens for bactericidal compounds against drug-resistant tuberculosis are beginning to yield novel inhibitors. However, reliable target identification remains challenging. Here, we show that tetrahydropyrazo[1,5-a]pyrimidine-3-carboxamide (THPP) selectively pulls down EchA6 in a stereospecific manner, instead of the previously assigned target Mycobacterium tuberculosis MmpL3. While homologous to mammalian enoyl-coenzyme A (CoA) hydratases, EchA6 is non-catalytic yet essential and binds long-chain acyl-CoAs. THPP inhibitors compete with CoA-binding, suppress mycolic acid synthesis, and are bactericidal in a mouse model of chronic tuberculosis infection. A point mutation, W133A, abrogated THPP-binding and increased both the in vitro minimum inhibitory concentration and the in vivo effective dose 99 in mice. Surprisingly, EchA6 interacts with selected enzymes of fatty acid synthase II (FAS-II) in bacterial two-hybrid assays, suggesting essentiality may be linked to feeding long-chain fatty acids to FAS-II. Finally, our data show that spontaneous resistance-conferring mutations can potentially obscure the actual target or alternative targets of small molecule inhibitors

Local immunity of the oral cavity at the employees of mining and processing works occupied with production and processing of copper-zinc ores

For the purpose of studying of local immunity of an oral cavity, studying of the dental status of employees of Uchalinsky Mining and Processing Integrated Works is carried out. Objects of a research were 235 male employees of Uchalinsky Mining and Processing Integrated Works aged from 18 up to 60 years and 90 people of control group who don't have professional harm and similar on age and sex sign. We have revealed the return correlation communication of indicators of local immunity of an oral cavity with severity of diseases of the parodont and with an experience of workers. Calculation of coefficient of balance of factors of local immunity at which borderline of local immunity has come to light at miners of UGOK has been made.С целью изучения местного иммунитета полости рта, проведено изучение стоматологического статуса работников Учалинского горно-обогатительного комбината. объектами исследования явились 235 работников мужского пола Учалинского горно-обогатительного комбината в возрасте от 18 до 60 лет и 90 человек контрольной группы, не имеющих профессиональной вредности и аналогичной по возрастно-половому признаку. Нами была выявлена обратная корреляционная связь показателей местного иммунитета полости рта со степенью тяжести заболеваний пародонта и со стажем работников. Был произведен расчет коэффициента сбалансированности факторов местного иммунитета, при котором выявилось у шахтеров УГОК пограничное состояние местного иммунитета

Methods of prevention and treatment of diseases of the oral cavity at the employees of mining and processing works occupied with production and processing of copper-zinc ores

Studying of the dental status of the employees of mining and processing works occupied with production and processing of copper-zinc ores is carried out. Objects of a research were 135 workers of Uchalinsky Mining and Processing Integrated Works occupied with production and processing of copper-zinc ores. At workers we have revealed high prevalence of caries of teeth, diseases of fabrics of the parodont and a mucous membrane of an oral cavity. In this regard there was a need of development of methods of treatment and prevention of dental diseases at workers of UGOK. We have created the program of prevention and treatment of dental diseases at employees of mining and processing works. Methods of treatment and prevention can be used for optimization of the existing system of protection of dental health of workers given and other similar enterprises.Проведено изучение стоматологического статуса работников горно-обогатительного комбината, занятых добычей и переработкой медно-цинковых руд. объектами исследования явились 135 рабочих Учалинского горно-обогатительного комбината, занятых добычей и переработкой медно-цинковых руд. У рабочих нами была выявлена высокая распространенность кариеса зубов, заболеваний тканей пародонта и слизистой оболочки полости рта. В связи с этим возникла необходимость разработки методов лечения и профилактики стоматологических заболеваний у работников УГОК. Нами была создана программа профилактики и лечения стоматологических заболеваний у работников горно-обогатительного комбината. Методы лечения и профилактики могут использоваться для оптимизации существующей системы охраны стоматологического здоровья работников данного и других подобных предприятий

Assessment of risk of development of diseases of the oral cavity in the employees of mining and processing works occupied with production and processing of copper-zinc ores

For the purpose of studying of risk of development of diseases of an oral cavity in the employees of mining and processing works occupied with production and processing of copper-zinc ores comprehensive dental examination of 235 workers and group of control of 90 people is conducted. Results of researches have shown that the dental incidence of workers of UGOK is caused by influence of harmful factors of production. In size of relative risk, the etiologichesky share has made 41-100% that corresponds to professionally caused and occupational diseases.С целью изучения риска развития заболеваний полости рта у работников горно-обогатительного комбината, занятых добычей и переработкой медно-цинковых руд, проведено комплексное стоматологическое обследование 235 рабочих и группы контроля из 90 человек. результаты исследований показали, что стоматологическая заболеваемость работников УГОК обусловлена влиянием вредных факторов производства. По величине относительного риска, этиологическая доля составила 41-100%, что соответствует профессионально обусловленным и профессиональным заболеваниям

A proteome-wide protein interaction map for Campylobacter jejuni

'Systematic identification of protein interactions for the bacterium Campylobacter jejuni using high-throughput yeast two-hybrid screens detected interactions for 80% of the organism's proteins