10 research outputs found
Metal–Organic Frameworks Constructed from Group 1 Metals (Li, Na) and Silicon-Centered Linkers
A series
of “light metal” metal–organic frameworks
containing secondary building units (SBUs) based on Li<sup>+</sup> and Na<sup>+</sup> cations have been prepared using the silicon-centered
linkers Me<sub><i>x</i></sub>SiÂ(<i>p</i>-C<sub>6</sub>H<sub>4</sub>CO<sub>2</sub>H)<sub>4‑<i>x</i></sub> (<i>x</i> = 2, 1, 0). The unipositive charge, small
size, and oxophilic nature of the metal cations give rise to some
unusual and unique SBUs, including a three-dimensional nodal structure
built from sodium and oxygen ions when using the triacid linker (<i>x</i> = 1). The same linker with Li<sup>+</sup> cations generated
a chiral, helical SBU, formed from achiral starting materials. One-dimensional
rod SBUs are observed for the diacid (<i>x</i> = 2) and
tetra-acid (<i>x</i> = 0) linkers with both Li<sup>+</sup> and Na<sup>+</sup> cations, where the larger size of Na<sup>+</sup> compared to Li<sup>+</sup> leads to subtle differences in the constitution
of the metal nodes
Anti-nicotine antibody titer and function in mice.
<p>Panel A: BALB/c mice (n = 12/gp) were immunized by IM injection with 10 µg of different nicotine Hapten-DT conjugates adjuvanted with Al(OH)<sub>3</sub> (40 µg Al<sup>3+</sup>) + CpG 24555 (50 µg) on days 0, 28 and 42. Plasma was collected on day 54 and anti-nicotine antibody levels determined by ELISA (Panel A). On day 56 animals received an IV injection of <sup>3</sup>H-nicotine (0.05 mg/kg) and plasma and brains collected. Panel B shows nicotine levels in plasma (ng-eq/mL), and Panel C shows nicotine levels in brain (ng-eq/g).</p
General scheme for addition of different linkers to Hapten 7.
<p>General scheme for addition of different linkers to Hapten 7.</p
Structures of different linker-modified nicotine hapten.
<p>Structures of different linker-modified nicotine hapten.</p
Nicotine and hapten structures.
<p>The thioacetate of Hapten 8 was deprotected to the thiol for coupling with DT.</p
Anti-nicotine antibody titer and function in mice.
<p>Panel A: BALB/c mice (n = 12/gp) were immunized by IM injection with 10 µg of different nicotine Hapten-DT conjugates adjuvanted with Al(OH)<sub>3</sub> (40 µg Al<sup>3+</sup>) + CpG 24555 (50 µg) on days 0, 28 and 42. Plasma was collected on day 54 and anti-nicotine antibody levels determined by ELISA (Panel A). On day 56 animals received an IV injection of <sup>3</sup>H-nicotine (0.05 mg/kg) and plasma and brains collected. Panel B shows nicotine levels in plasma (ng-eq/mL), and Panel C shows nicotine levels in brain (ng-eq/g).</p